Moshe Biton

[Moshe Biton @bitonm]

Excited to share our new paper in Nature Immunology! 🦠🔬
https://t.co/bFpCUGRz38
We uncover a central role for intestinal stem cells in defending the tissue against Salmonella infection.

A huge thanks to all collaborators and team members who made this work possible!

[Weizmann Canada @WeizmannCanada]

🧬 What if the immune system could remember cancer the way it remembers a vaccine?

In @CellPressNews’ Immunity, researchers from @ZivShulman’s lab at @WeizmannScience discovered memory B cells that can recognize ovarian tumours and produce targeted antibodies.

#CancerResearch

[Igor Ulitsky @IgorUlitsky]

Now out in @NatureBiotech ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones. https://t.co/01NroM67dK

[Moshe Biton @bitonm]

Feeling truly grateful for all the warm comments, support, and retweets from colleagues, friends, and the broader community. It really means a lot to us and to everyone involved in the study. 🙏🦠🔬.
Stem cells rock!

[Moshe Biton @bitonm]

Excited to share our new paper in Nature Immunology! 🦠🔬
https://t.co/bFpCUGRz38
We uncover a central role for intestinal stem cells in defending the tissue against Salmonella infection.

A huge thanks to all collaborators and team members who made this work possible!

[Biton Lab @bitonslab]

🧵 It’s out 📑
What happens when Salmonella reaches the intestinal crypt, not just the surface epithelium, but the specialized cells that maintain and defend the tissue?
Our paper follows bacterial invasion at single-cell resolution

https://t.co/mOR6dwOCUj
@NatImmunol
1/

[Moshe Biton @bitonm]

We show that stem cells are directly invaded by the pathogen and respond by activating inflammasome signaling, triggering cellular remodeling toward cells with antimicrobial properties. This early epithelial defense program helps protect the tissue at early infection time points.

[Biton Lab @bitonslab]

Excited to share our new @biorxivpreprint from the lab!
We show that intestinal Lgr5⁺ stem cells are active luminal sensors that use apical TLR2 signaling to detect microbiota-derived cues and regulate epithelial differentiation and antimicrobial defense.
https://t.co/4ZtBRHGHab

[Biton Lab @bitonslab]

Check out our latest pre-print on @biorxivpreprint ! We show that the intestinal MHC II self-ligandome is spatially compartmentalized across villus, crypt, and immune niches, and is dramatically rewired during injury toward damage-associated self-antigens.
https://t.co/j9lKSXVI35

[bioRxiv Immunology @biorxiv_immuno]

Epithelial MHC II antigen presentation dynamically informs intestinal homeostasis and injury https://t.co/bYlE94JNxi #biorxiv_immuno

[Igor Ulitsky @IgorUlitsky]

How we’re rebuilding the Weizmann Institute — and our hopes for a better future https://t.co/ExEoJsUtgH

[Moshe Biton @bitonm]

Proud to see this study from our @bitonslab in collaboration with @LabSagi now on @biorxivpreprint!

Brilliant work by the team, congrats!

[Biton Lab @bitonslab]

Excited to share our latest preprint with @Sagi_Lab on @biorxivpreprint!
The ECM remembers inflammation—forming a scarred niche that reprograms stem cells and drives chronic disease.
The ECM isn't passive—it instructs.
🔗https://t.co/AFlo434OA5
#IBD #ECM #StemCells #Inflammation

[Xavier Lab @TheXavierLab]

Out now in @Science! We and the @KuchrooLab described responses of enteric neurons to inflammatory cues during infection, showing that primary sensory neurons detect type 2 cytokines, balance neuropeptides, and influence site-specific immunity.

https://t.co/jel4IWa6K9

[האוניברסיטה העברית בירושלים @HebrewU_heb]

האוניברסיטה העברית גאה לברך את פרופ' ינון בן-נריה מהפקולטה לרפואה על זכייתו בפרס ישראל בתחום חקר הרפואה, על פועלו בחקר מחלת הסרטן.
ועדת הפרס ציינה בנימוקיה כי "פרופ' בן-נריה הוא חוקר פורץ דרך בתחום חקר מחלת הסרטן, שגילה מנגנונים להתפתחות הסרטן שהובילו ועדיין מובילים ליצירת תרופות לטיפול במחלה. מחקריו של בן נריה התפרסמו בבמות מדעיות ובעיתונות המקצועית הטובה והאיכותית ביותר בעולם".
בין התרומות של פרופ' בן-נריה לחקר הסרטן נמנים זיהוי הגורם המולקולרי הראשון המסביר את הקשר בין דלקת וסרטן, גילוי דלקת סמויה הנפוצה בתאים סרטניים ומזרזת התפתחות סרטן בנוכחות מוטציות סרטניות, ואפיון גנים המשחקים תפקיד מפתח בסרטן המעי הגס.ל
בין התרומות של פרופ' בן-נריה לחקר הסרטן נמנים זיהוי הגורם המולקולרי הראשון המסביר את הקשר בין דלקת וסרטן, גילוי דלקת סמויה הנפוצה בתאים סרטניים ומזרזת התפתחות סרטן בנוכחות מוטציות סרטניות, ואפיון גנים המשחקים תפקיד מפתח בסרטן המעי הגס.
צילום: Bruno Charbit

[Kuchroo Lab @KuchrooLab]

🙌Excited to share that our PI Vijay Kuchroo will be awarded the 2025 AAI-Thermo Fisher Meritorious Career Award, for outstanding research contributions to immunology. Vijay will be presented the award & giving a lecture in Honolulu at the annual @ImmunologyAAI meeting in May.

[Toufic Mayassi @TouficMayassi]

1/ Keen to share the story of my postdoc research in @TheXavierLab! We built a massive resource characterizing the spatial landscape of the gut, and yes, we dug deep into the biology too. If you’ve got a minute, let me walk you through the story. 🧵👇

https://t.co/sKL3yyCCKZ

[Karuna Ganesh @KarunaMDPhD]

Thrilled to share our paper now out @Nature delineating #plasticity during #CRC #metastasis, a fantastic collaboration led by @andrewrmoorman @elliebenitez11, and @f_cambuli from the @KarunaGaneshLab and @dana_per lab! https://t.co/NYQRHfq3gz
https://t.co/Z4GFwqL8G2. A 🧵

[dana_peer @dana_peer]

This paper exemplifies the power of @MSKCancerCenter and why I love working here. Access to unique tumor samples, more importantly brilliant physician scientists and most important driven and talented trainees to make it all happen. Kudus to @andrewrmoorman and @elliebenitez11

[Moshe Biton @bitonm]

@leeat_keren Congrats!

[Leeat Keren @leeat_keren]

Preprint alert! A spatial atlas of human gastro-intestinal acute GVHD reveals epithelial and immune dynamics underlying disease pathophysiology https://t.co/qtyqlepJod. We examined how immune cells are organized in the gut and what happens to them in GVHD. TL;DR Timing is key!

[Moshe Biton @bitonm]

@leeat_keren @SachaLEBON @matanhofree Thanks!

[Moshe Biton @bitonm]

Our latest preprint is out! 🚨We discovered that intestinal stem cells actively fight bacterial infections. Learn more about it in our new study by @SachaLEBON in collaboration with @matanhofree https://t.co/ZMppWIR7LD