Xu Zhou (周旭)

AP @BostonChildrens @harvardmed AM @broadinstitute inflammation, tissue biology, quant.&systems immunology #1stGen #ImmigrantScientists @xuzhoulab.bsky.social

[Xu Zhou (周旭) @XuZhouLab]

Beyond excited to share our #NewPaper in @CellCellPress! Inflamed environments acidify intracellular pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of inflammation. #inflammation #pH https://t.co/VMQmTxQgLM

[Jane Skok @jane_skok]

● Twist, unwind, repeat. Dr. Chongyi Chen (NIH) investigates the forces that keep our DNA topologically balanced—and what happens to gene regulation, chromatin architecture, and genome stability when that balance is disrupted! :https://t.co/JJa4LWw3Tp #chromatin2026

[Xu Zhou (周旭) @XuZhouLab]

@dana_peer @rosslevinemd Congratulations Dana!

[Xu Zhou (周旭) @XuZhouLab]

@Tcellogic @EJohnWherry @theNAMedicine Congratulations Sue!!!

[Miles Huseyin @mileshuseyin]

1/9) Excited to share my preprint on Polycomb 3D chromatin interactions from my postdoc with @Anders_S_Hansen!

We were surprised to find that canonical PRC1 doesn't seem to be the only contributor to these interactions:
https://t.co/uWY05Gqo8i

[Anders Sejr Hansen @Anders_S_Hansen]

Check out our new preprint led by @mileshuseyin unexpectedly discovering Polycomb 3D interactions independent of cPRC1.

Miles led this ambitious study. He's also on the faculty job market, and I can't recommend him highly enough for important and comprehensive science!

[Xu Zhou (周旭) @XuZhouLab]

@LilingWanLab @KeystoneSymp @BradEBernstein Great meeting!

[Xu Zhou (周旭) @XuZhouLab]

@pdhsu Congratulations Patrick!

[Xu Zhou (周旭) @XuZhouLab]

@Y_Ryan_Lu @JswLab @bruce_ksander Congratulations Yuancheng!!!!

[Yuancheng Ryan Lu @Y_Ryan_Lu]

1/ Excited to share our new preprint from a joint collaboration between @JswLab + @Bruce_Ksander!

Aging is marked by a progressive loss of resilience to stress. Can we systematically search the human ORFome for genes that make vulnerable cells more resilient?

Performing such a genome-scale ORF screen led us to NKX2-5—a heart transcription factor we engineered to restore vision, and improve health in aged mice.

A breakdown🧵
🔗 https://t.co/WVIO7JOx3p

[Jonathan Kagan @jkagan1]

Thank you to Boston Children’s Hospital for highlighting our recent publication, describing:
Receptor Free Signal Transduction.
https://t.co/FcxoYjNB3n

[Nature Rev Immunol @NatRevImmunol]

The next big questions in immunology https://t.co/JPTwmdi9Ej

[Xu Zhou (周旭) @XuZhouLab]

@jkagan1 congrats again @jkagan1 & Daniel! One of the most ancient immune receptors still surprise us all the time!

[Jonathan Kagan @jkagan1]

Today, the Toll-like Receptors reveal a new mechanism of signal transduction: Receptor-Free Signal Transduction.
https://t.co/AqzQvvMLRs

[Xu Zhou (周旭) @XuZhouLab]

Congrats Daniel & @jkagan1 for another landmark study! 👏👏Many systems showed how expression kinetics can be encoded with receptor based signaling - frequency & duration signaling 👉gene expression. Couple signaling-some to gene beyond time-scale of receptors is a game changer!

[Jonathan Kagan @jkagan1]

https://t.co/J9xnnt15Nb

[Vishva Dixit @dixitvishva]

SURPRISE! Key interferon-stimulated genes (ISGs) can be induced without interferon! Sounds like an oxymoron, but it is true! Read the paper to find out more.

Switching of transcriptional control from interferon regulatory factor 2 to interferon regulatory factor 1 drives innate immune cell activation: Cell https://t.co/sozKwaQE39

[Xu Zhou (周旭) @XuZhouLab]

just talked about this idea with lab and saw this work coming out! congrats to @ReganVolk @amycfanphd and all. it is challenging to target specific macrophage subtypes but possible to do it based on on their interacting cells?https://t.co/hlJcuUCPCx

[Miri Adler @MiriAdler]

Very excited to share our new paper in @CellReports - the first Adler Lab in-house paper! 🎉

Led by @SYonassi, @noaGoldenber & @AviaWalfisch, together with @Eitan42Cohen, @Einat_Tamar & @XuZhouLab.

We ask how supportive cells coordinate division of labor across tissues.
🧵

[Xu Zhou (周旭) @XuZhouLab]

@wuzhengherbert wow! Congrats Zheng!

[Herbert Zheng Wu @wuzhengherbert]

First study out! Using a new cooperative paradigm and multi-agent inverse RL, we show that mice spontaneously adopt leader/follower roles, and the prefrontal cortex encodes these role dynamics and an egocentric social value map of the partner’s position.
https://t.co/bjXSw3gz7c

[Xu Zhou (周旭) @XuZhouLab]

How to turn unprecedented cellular data into insights of tissue function? #TissueUnits, #DivisionOfLabor, and tissue-specific #Archetype. Congrats to @MiriAdler &team, go-to for tissue systems biology https://t.co/oy0Je45QV6🔥honored being a small part👇
https://t.co/MJXQUSpfeE