Biton Lab

Understanding mucosal tissue dynamics

[Biton Lab @bitonslab]

Read the full story here:

https://t.co/mOR6dwOCUj
@NatImmunol

Shout-out to the great team and our amazing collaborators who worked on this project over the years

@SachaLEBON @bitonm @matanhofree

10/10

[Biton Lab @bitonslab]

🧵 It’s out 📑
What happens when Salmonella reaches the intestinal crypt, not just the surface epithelium, but the specialized cells that maintain and defend the tissue?
Our paper follows bacterial invasion at single-cell resolution

https://t.co/mOR6dwOCUj
@NatImmunol
1/

[Biton Lab @bitonslab]

Beyond infection, this raises an important possibility:
ISC inflammasome activation may shape epithelial remodeling in chronic inflammatory and neoplastic contexts, including IBD and colorectal cancer.
9/

[Biton Lab @bitonslab]

Our findings uncover a mechanism by which adult stem cells integrate environmental signals to maintain tissue homeostasis.

Congrats to @Aviya_HM and the whole Biton lab team!🎉🎉🎉

[Biton Lab @bitonslab]

Excited to share our new @biorxivpreprint from the lab!
We show that intestinal Lgr5⁺ stem cells are active luminal sensors that use apical TLR2 signaling to detect microbiota-derived cues and regulate epithelial differentiation and antimicrobial defense.
https://t.co/4ZtBRHGHab

[Biton Lab @bitonslab]

Check out our latest pre-print on @biorxivpreprint ! We show that the intestinal MHC II self-ligandome is spatially compartmentalized across villus, crypt, and immune niches, and is dramatically rewired during injury toward damage-associated self-antigens.
https://t.co/j9lKSXVI35

[Biton Lab @bitonslab]

Excited to share our latest preprint with @Sagi_Lab on @biorxivpreprint!
The ECM remembers inflammation—forming a scarred niche that reprograms stem cells and drives chronic disease.
The ECM isn't passive—it instructs.
🔗https://t.co/AFlo434OA5
#IBD #ECM #StemCells #Inflammation

[International Union of Immunological Societies @iuis_online]

Join us at #IUIS2025 in Vienna, Austria for an exciting plenary on Innate Immunity and Inflammation with speakers, Dr. Miriam Merad (@MiriamMerad, IUIS President) and Dr. Caetano Reis e Sousa (@ReiseSousaLab)!

Learn more and register at https://t.co/GbAHxFdRFA!

[International Union of Immunological Societies @iuis_online]

Happening TOMORROW! Don't miss #IUIS2023 Rising Star Dr. Moshe Biton (@bitonm)'s talk on "Elucidating intestinal stem cell innate immune properties" on Fri, 1 Dec, 10:00 - 10:15 SAST in Auditorium I.

Check out this clip to learn more about his research program!

[Karina Yaniv @KarinaYaniv]

"In the face of darkness, let our voices be the guiding light". A clear message from the
@WeizmannScience
to our fellow scientists and friends. Thanks for being there for us, we will never forget 🙏📷 #StrongerTogether.

[Biton Lab @bitonslab]

Excited to host Prof. Xavier w/ @BINAWIS1 ! His captivating lecture on Controllers of Barrier Defense and translational clinical research left us all feeling inspired and motivated. Amazing talk ! Thank you for sharing your expertise with us, Prof. Xavier ! @TheXavierLab

[Biton Lab @bitonslab]

Very exciting h trip at #ILANIT2023 conference! Our team rocked the stage with talks from @bitonm, Vlad, and @SachaLEBON, while Carmel and @Aviya_HM wowed us with their poster presentations. So proud to be part of such a talented and innovative group! 🤩🎉👩‍🔬👨‍🔬📊📈

[The Immunology and Regenerative Biology Department @IRB_Department]

Can't end 2022 without some pictures from our IRB departmental retreat, right?