Xavier Lab

Genes to functions. Microbiome in health & disease. Computational biology. Chemical biology. Innate & adaptive immunity.

[Xavier Lab @TheXavierLab]

New website launch for the World Diet Initiative—an international effort to map global dietary patterns and their impacts on human health.

The site is now accepting heritage diet submissions to build the open-access World Diet Atlas.
https://t.co/GGGfCiev0w

[Xavier Lab @TheXavierLab]

Congratulations, @SachaLEBON on some great work! Excited to see this come out after all your hard work.

[Sacha LEBON @SachaLEBON]

My first first-author paper is (finally) out !

Big shoutout to my amazing co-authors from @bitonm lab, @matanhofree lab and collaborators from @WeizmannScience, @IRB_Department and @HebrewU community for their contributions !

[Cell Host & Microbe @cellhostmicrobe]

Early-life interventions & airway microbiome

Nasal microbial gene atlas in infants w/cystic fibrosis. Hypertonic saline inhalation reshapes microbiome, selects salt-tolerant H. influenzae & ⬆️transporters linked to antibiotic tolerance @TheXavierLab
https://t.co/3sQEjFPK2h

[Cell Host & Microbe @cellhostmicrobe]

What the nose knows of cystic fibrosis microbes and hypertonic saline

Bouzek Previews work by @TheXavierLab presenting microbial gene atlas of nasopharyngeal swabs in infants w/cystic fibrosis & healthy controls & IDing impacts of clinical interventions
https://t.co/PeaLxgM4db

[Xavier Lab @TheXavierLab]

Excited to share this new preprint from a large collaborative effort using #exome + #genome sequencing, moving beyond GWAS to implicate 68 genes in #IBD through rare protein-coding variation.

https://t.co/K1Gcfr09B6

@broadinstitute
@MGHMolBio
@MGBResearchNews

[Xavier Lab @TheXavierLab]

Excited to share our new @ImmunityCP review, discussing how advances in functional genomics and chemical biology are enabling the translation of IBD genetics into mechanistic understanding and new therapeutic hypotheses.

https://t.co/zWEdLuBzwP

#IBD #inflammatoryboweldisease

[Xavier Lab @TheXavierLab]

We found and validated in vitro that early-life perturbations (hypertonic saline inhalation therapy) can select for microbial traits linked to salt and antibiotic tolerance.

#antibiotics #cysticfibrosis #microbial

@broadinstitute @MGBResearchNews

[Xavier Lab @TheXavierLab]

Out now @cellhostmicrobe! In collaboration with @RuthSteinbaer and Swiss clinicians, we built the largest nasal microbial gene atlas in infants w/ and w/o cystic fibrosis to date (cont.)

[Xavier Lab @TheXavierLab]

Our latest work, with @MikaKivimaki lab, now online @alzdemjournals: we used single-cell and GWAS data to uncover genes in peripheral blood immune cells associated with Alzheimer’s disease.

https://t.co/h6VKNJju36

@broadinstitute
@MGHMolBio
@MGBResearchNews

#Alzheimers

[Xavier Lab @TheXavierLab]

New work with @CarolineUhler, now online in @NatureComms! We developed TRIM, a multimodal framework integrating T cell RNA and TCR profiling to predict T cell responses to cancer treatment.
https://t.co/STBFqkEAB3

@broadinstitute
@MGHMolBio
@MGBResearchNews

[Xavier Lab @TheXavierLab]

@MGBResearchNews @MGHMolBio @broadinstitute

[Xavier Lab @TheXavierLab]

New study, in collaboration with @Honda1Kenya, out now in @Nature. We show how a low protein diet drives a microbiota-dependent induction of thermogenic brown adipocytes via FXR & FGF21 pathways.

https://t.co/dGz6e94ak9

[Xavier Lab @TheXavierLab]

@MGBResearchNews @MGHMolBio @broadinstitute

[Xavier Lab @TheXavierLab]

Excited to share our new study defining the multicellular ecosystem of atopic dermatitis. Integrating >700k single cells from healthy and inflamed skin, we uncover disease-specific immune circuits linked to disrupted keratinocyte differentiation.
https://t.co/PbVfffuLUP

[Xavier Lab @TheXavierLab]

Thank you to all the authors, including @dalygene and @masakanai for their hard work and contributions!

@MGBResearchNews @MGHMolBio

[Xavier Lab @TheXavierLab]

Check out this great write-up of a recent study between the @broadinstitute, University of Helsinki, and other institutions which has found more than 400 genetic markers that are linked to autoimmune hypothyroidism (AIHT). (1/4)

https://t.co/i5l3wAdKuM

[Xavier Lab @TheXavierLab]

This paper charts a clear path to understanding how genetics can not only find the genetic variants linked to a disease, but also dissect them into clearly distinct groups that represent independent components of the disease. (3/4)

https://t.co/JDxJhIbzNO

[Kumar Thurimella, MD PhD @k00kumar]

1/ Our paper is out today in @CellSystemsCP. We used protein language models and deep learning to identify candidate protease allergens in the human microbiome.

https://t.co/ZP3p3tfElS

[Xavier Lab @TheXavierLab]

2/2 For an in-depth walkthrough, check out this Tweetorial by first author @k00kumar.

https://t.co/yg3h6zDmqL

[Kumar Thurimella, MD PhD @k00kumar]

1/ Our paper is out today in @CellSystemsCP. We used protein language models and deep learning to identify candidate protease allergens in the human microbiome.

https://t.co/ZP3p3tfElS

[Xavier Lab @TheXavierLab]

1/2 New paper out now in Cell Systems @CellPressNews describing development of a deep learning framework to predict allergenic microbial proteases!
https://t.co/n7XPrLb9Er

@broadinstitute @MGHMolBio @MGBResearchNews