Xavier Lab

Genes to functions. Microbiome in health & disease. Computational biology. Chemical biology. Innate & adaptive immunity.

[Xavier Lab @TheXavierLab]

Learn more and apply: https://t.co/RVVGFnDWS6

[Xavier Lab @TheXavierLab]

Applications are open for the Klarman Fellowship at @broadinstitute! We are looking for postdoctoral researchers to join the GaMBiT Initiative to develop innovative technologies that translate human genetic discoveries into disease mechanisms, biomarkers, and therapeutic leads.

[Xavier Lab @TheXavierLab]

@broadinstitute @MGBResearchNews @MGHMolBio

[Xavier Lab @TheXavierLab]

New work with @CarolineUhler is out in @NatureComms! We developed StriMap, a deep learning model to predict TCR–peptide–HLA interactions, and used it to uncover bacterial peptides that activate an ankylosing spondylitis-associated TCR.

https://t.co/WhkhS37hmB

[Xavier Lab @TheXavierLab]

Check out this Tweetorial by first author @masakanai for all the details:

https://t.co/nIxrq2Vt8y

@broadinstitute
@MGHMolBio
@MGBResearchNews

[Masahiro Kanai @masakanai]

Our single-nucleus immune multiome atlas is now out in @Nature! 🧬

10M PBMCs from 1,108 @FinnGen_FI donors recruited by @FRCBSresearch, profiled at @broadinstitute KCO with chromatin accessibility and gene expression in the same nuclei, to trace how disease variants act 🧵👇

[Xavier Lab @TheXavierLab]

New work in @Nature with @dalygene led by @masakanai! We used population-scale chromatin and transcriptomic profiling of immune cells from FinnGen participants to connect disease-associated variants to gene regulation and disease risk.

https://t.co/DbgbzqAlZg

[Xavier Lab @TheXavierLab]

We teamed up with @HLahdesmaki to develop and validate PepGen, the first fully generative model capable of synthesizing MHCII peptide binders conditioned on allele, partial sequences, and continuous affinity

Read the results here: https://t.co/XnQaufD2lI

@broadinstitute

[Xavier Lab @TheXavierLab]

New preprint from our collaboration with @CarolineUhler at @broadinstitute on TissueFormer, a new tool for predicting spatial gene expression from histology images at cellular resolution

https://t.co/46D2T8YvKN

[Xavier Lab @TheXavierLab]

First author Marie is now the Group Leader in Microbiome Studies at the Kennedy Institute of Rheumatology, @UniofOxford – Congratulations, Marie!

@broadinstitute
@MGHMolBio
@MGBResearchNews

[Xavier Lab @TheXavierLab]

Out now in @NatureMicrobiol: Marie Pust and colleagues developed metastrand, a tool to quantify
strand-specific transcription in microbiomes at gene-level resolution, and used it to reveal
microbial adaptations associated with IBD.
https://t.co/wUY8I1dTu4

#metastrand #IBD

[Xavier Lab @TheXavierLab]

Building on our previous lung atlas, which identified pathogenic CTHRC1-high #fibroblasts enriched within fibrotic niches, this study further defines the molecular mechanisms that drive IPF.

https://t.co/8US6PY1gMD

@MGBResearchNews
@MGHMolBio
@broadinstitute

[Xavier Lab @TheXavierLab]

New work with @LabMedoff online now!

ADAMTS14 regulates YAP-driven fibroblast activation in IPF. We define an ADAMTS14–collagen V–focal adhesion pathway that contributes to #fibrosis, highlighting ADAMTS14 as a potential therapeutic target.

https://t.co/3TXkezIskX

[Xavier Lab @TheXavierLab]

Check out this @NatureMedicine Comment about the importance of studying heritage diets and the World Diet Initiative’s efforts to translate dietary diversity into health benefits for the global community:

https://t.co/2bor4AkOzC

[Xavier Lab @TheXavierLab]

Join us and @GeneLayInst on July 31st for the Annual Symposium! This year's speakers include Marco Colonna, Shimon Sakaguchi, @stefanispranger, and @victora_lab. Register using the QR code in the flyer!

#inflammation #immunity #disease #genelayinstitute

[Xavier Lab @TheXavierLab]

Good luck at UCSF (Anna), University of Washington (Regan), and MIT (Tanvi). We will miss you!

[Xavier Lab @TheXavierLab]

It's that time of year again--we are saying goodbye to more of our youngest and brightest lab members as they transition to the next steps of their careers, either in grad school or in other institutions. This week, we are saying goodbye to Anna, Regan, and Tanvi.

[Xavier Lab @TheXavierLab]

New website launch for the World Diet Initiative—an international effort to map global dietary patterns and their impacts on human health.

The site is now accepting heritage diet submissions to build the open-access World Diet Atlas.
https://t.co/GGGfCiev0w

[Xavier Lab @TheXavierLab]

Congratulations, @SachaLEBON on some great work! Excited to see this come out after all your hard work.

[Sacha LEBON @SachaLEBON]

My first first-author paper is (finally) out !

Big shoutout to my amazing co-authors from @bitonm lab, @matanhofree lab and collaborators from @WeizmannScience, @IRB_Department and @HebrewU community for their contributions !

[Cell Host & Microbe @cellhostmicrobe]

Early-life interventions & airway microbiome

Nasal microbial gene atlas in infants w/cystic fibrosis. Hypertonic saline inhalation reshapes microbiome, selects salt-tolerant H. influenzae & ⬆️transporters linked to antibiotic tolerance @TheXavierLab
https://t.co/3sQEjFPK2h

[Cell Host & Microbe @cellhostmicrobe]

What the nose knows of cystic fibrosis microbes and hypertonic saline

Bouzek Previews work by @TheXavierLab presenting microbial gene atlas of nasopharyngeal swabs in infants w/cystic fibrosis & healthy controls & IDing impacts of clinical interventions
https://t.co/PeaLxgM4db