Joazeiro Lab

💙E3 Ubiquitin ligases and Protein Quality Control: mechanisms, functions and relevance for aging-related diseases, in particular neurodegeneration

[Joazeiro Lab @LabJoazeiro]

The Mother of All Ribosome Collisions
Life before #ubiquitin: B. subtilis MutS2/RqcU senses translational stalls that lead to #ribosome collisions, then elicits degradation of the incomplete nascent-chains. Excited to share our findings, online @Nature today.
#RQC

[ZMBH - Center for Molecular Biology Heidelberg @ZmbhH]

A team of researchers led by ZMBH's PIs C. Joazeiro @LabJoazeiro and S. Pfeffer @PfefferCryoLab discovered how the bacterial MutS2 protein prevents damage by stalled ribosomes! Further details in Nature https://t.co/ZMiSZDxPVb

[Joazeiro Lab @LabJoazeiro]

Please RT

[Joazeiro Lab @LabJoazeiro]

A Tenure Track Professorship at the ZMBH in Heidelberg, Germany, has just been advertised, (18 January 2026 deadline)
https://t.co/rgAyeONxDq

I encourage excellent candidates in the broad #proteostasis and/or translation fields to apply! @scijobs @sciencejobs_eu

[Joazeiro Lab @LabJoazeiro]

@mohitasya Thanks, Mohit! I hope all is well!

[Joazeiro Lab @LabJoazeiro]

With this new funding, we’re hiring PhDs and #postdocjobs

Our #ERCAdG studies on the role of #RQC #ribosome #ubiquitin in #neurodegeneration will include using iPSCs, i-neurons, mammalian TC. The lab also has ongoing projects on #mitochondria and bacterial RQC.

[Joazeiro Lab @LabJoazeiro]

Thrilled and honored to receive the #ERCAdG! This will fund us for the next 5 yrs for groundbreaking research

My project SuTra focuses on the Surveillance of Translation, from sensing #ribosome stalling to #RQC. We aim to learn how defective surveillance causes neurodegeneration

[Joazeiro Lab @LabJoazeiro]

And the flier for PhD jobs. Thanks!

[Joazeiro Lab @LabJoazeiro]

And here goes our brand new flyer #postdocjobs. Please RT!

[Joazeiro Lab @LabJoazeiro]

@MAmbrozkiewicz Thanks, Mateusz!

[Joazeiro Lab @LabJoazeiro]

Thrilled and honored to receive the #ERCAdG! This will fund us for the next 5 yrs for groundbreaking research

My project SuTra focuses on the Surveillance of Translation, from sensing #ribosome stalling to #RQC. We aim to learn how defective surveillance causes neurodegeneration

[European Research Council (ERC) @ERC_Research]

📣 Good news: 281 top researchers have just won ERC Advanced Grants!

The new funding, worth nearly €721 million, is part of the 🇪🇺 EU’s #HorizonEurope programme.

Read more 👉 https://t.co/62GOFDjQYq

#ERCAdG #FrontierResearch @EUScienceInnov

[Joazeiro Lab @LabJoazeiro]

@scafrancesco1 Grazie, Francesco!

[Joazeiro Lab @LabJoazeiro]

@RalphSGrand Thanks, Ralph!

[Joazeiro Lab @LabJoazeiro]

@danetteldaniels Many thanks, Danette!

[Joazeiro Lab @LabJoazeiro]

Thanks, Ino! Thanks also to the LS1 panel for a constructive, fun interview! And congratulations to all fellow awardees! #ribosome #RQC #ubiquitin https://t.co/DyQNNo5GcT

[Joazeiro Lab @LabJoazeiro]

Thanks for your many contributions, Ivan. And of course, we would not have known about this amazing venue had you not pioneered meetings here.

[Ivan Đikić @iDikic2]

Impressive #EMBOubiquitin24 in #Cavtat with more than 300 participants & active discussions at posters. Superb success- thx to the organisers @MerblYifat76992, @YKulathu, @LabJoazeiro, @polosimona1, @EMBOevents 🙌👏🫶👍
The hotel and weather matched the quality of science 😊
⁩

[Joazeiro Lab @LabJoazeiro]

Thanks, Shalini. Your talk was awesome!

[Shalini Agarwal @Agarwal_Shal04]

Grateful to connect and learn from the great minds in ubiquitin, proteostasis and organelle quality control! Such a well-organised event! #EMBOubiquitin2024

[Joazeiro Lab @LabJoazeiro]

The credit to brilliant and fun thesis defense poster goes to Giuliano Arcaio

[Joazeiro Lab @LabJoazeiro]

Congratulations to my stellar (ex) PhD student Federico and all the awardees and honorable mentions for this achievement!

[IMP @IMPvienna]

@huangkun1995 @EdinburghUni @irmantas_mogila @VU_LT @AtvuLsc @schulluc @mpi_marburg @maxplanckpress @ctstankey @Dr_James_Lee @crickinstitute @ToneyanSh @pkoo562 @CSHL @viennabiocenter honourable mentions: Christian Baca from @RockefellerUniv, Federico Cerullo from ZMBH Heidelberg (@UniHeidelberg), Pascal Devant from @Harvard, Leonard Ernst from @mpi_marburg @maxplanckpress 9/

[Joazeiro Lab @LabJoazeiro]

Federico followed up on our discovery that bacteria also have an RQC pathway. In collab w @PfefferCryoLab, he elucidated mechanisms underlying Ala-tailing by RqcH (the homolog of Rqc2/NEMF), and discovered a factor that senses collided ribosomes upstream of RQC (hence, RqcU).

[Danette Daniels @danetteldaniels]

Don’t miss our next free virtual networking events in July! Will be fantastic ☺️

[Jonathan Pruneda @jnpruneda]

Bacteria can counter noncanonical lipid ubiquitination with a #ubiquitin esterase! Fantastic collaboration with @ThurstonLab and @CMBI_Szczesna, with @r_lacoursiere driving our side of the project using some amazing tools built by the Geurink lab.

[Joazeiro Lab @LabJoazeiro]

@alessiociulli @kyliejwalters @FASEBorg @DanNomura @chiaramaniaci @danetteldaniels @iDikic2 @VdangioE3lab @SLorenzLab @hw1o9 @paganolab @Bertolotti_lab @YKulathu Mohit is actually on X: @mohitasya

[Joazeiro Lab @LabJoazeiro]

@alessiociulli @kyliejwalters @FASEBorg @DanNomura @chiaramaniaci @danetteldaniels @iDikic2 @VdangioE3lab @SLorenzLab Thanks to you for the active participation, @alessiociulli! I had a terrific time and feedback like yours makes us feel the effort involved in organizing the meeting was well worth it.

Here's @hw1o9 @paganolab @SLorenzLab @Bertolotti_lab @YKulathu and Sherry, Mohit & Filippo