After an enormous effort, finally out! Our biochemical, computational, proteomic, and lipidomic data unravel the regulatory mechanism of CHIP processivity and reveal its role in lipid metabolism.
#proteostasis#ubiquitinligase#metabolism
https://t.co/aMuWZHQtY3
Farming arose on multiple continents among populations with radically different cultures and environments and with no means of communicating with each other – how did it crop up independently at about the same time? https://t.co/t7a0ACd72g
Biologists are discovering a world of beings tinier than viruses that appear to be everywhere – even living inside us. We have no idea what most of them are doing, but they raise profound questions about what life is and how it got started. https://t.co/puDgp6VjE4
Join the lab if you're passionate about ubiquitin research and enjoy collaborating with a supportive team, working closely with a PI who personally takes interest in developing the project.
We have an open postdoc position! Join us to study how ubiquitin ligases and non-canonical modifications regulate protein stability.
🗓️Apply by: 10.03.2025
🔬Start: 01.08.2025 | Warsaw
💰Salary: ~8300 PLN gross
More & apply: https://t.co/e9IRTIgzrW
Please share! 🚀
Microplastics have been found just about everywhere scientists have looked. Now scientists are trying to determine their effects on your health
https://t.co/G4wl3mRP7F
1/ Excited to share the first preprint from my PhD work co-authored with @alessandrick on how UFMylation and the ribosome-associated quality control (RQC) pathways collaborate to clear stalled ribosomes at the ER! #UFMylation#qualitycontrol#ER
https://t.co/L7B5KD5RGQ
🧵(1/8)
Check out our latest review on Regulation of physiological and pathological condensates by molecular chaperones at @FASEBPubs. Thanks to @AkareeNadeen for spearheading, and it was also fun to work with Serena Carra! https://t.co/o3QNS97AJZ
We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵
@LeopoldParts, Pierre Murat
New paper just dropped on @nchembio 🥳 A powerful platform for the rapid discovery of cyclic peptide inhibitors of protein aggregation!!! This is a nice collab with Prof. Tina Wang lab at @UWMadisonChem and congrats to Jingwei @zhjiww 🥳
https://t.co/uBuJU93XPJ
Super excited to finally share our new manuscript, out today in @NatureCellBio! This is the culmination of 6 years of work examining a seemingly simple question: What are the metabolic requirements for overcoming mitochondrial stress?
https://t.co/btsItt3xog
"Scientific breakthroughs do not happen in isolation; progress depends on the collective contributions of many. This prize celebrates the work of large communities of scientists over many years."
- chemistry laureate David Baker in his Nobel Prize banquet speech.
Read his full speech here: https://t.co/zQThnFLzDD
If you're thinking about going on the faculty job market, take a look at this advice doc I just shared with https://t.co/g8QLJ3PqZl: I collected my thoughts about the whole dang thing, from finding positions to negotiating a contract, & I hope y'all find it helpful!
We are thrilled to share our new preprint around oncoprotein degradation in vivo —a fantastic collaboration with our friends in Salamanca @lab_santamaria@ciccancer! 😃 @IRBBarcelona#TPD#KRAS
👇
https://t.co/EFZBWFoNHg
Excited to share our latest preprint on @biorxivpreprint: "The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro".
https://t.co/F07r55cMzz
🎉 Researchers from IIMCB, led by @wojtek_pokrzywa , have been honored by the @PAN_akademia for groundbreaking discoveries in proteostasis mechanisms 🌟👏
👉Read more: https://t.co/kWXsAjofng
Excited to report our discovery of an important component of the oxidative stress response, the E3 ligase TRIP12. It acts as a chain elongation factor that amplifies CUL3-KEAP1 activity to drive NRF2 degradation as cells recover from stress.
https://t.co/7wEkn6nznp