LechtenbergLab

News and updates from the Lechtenberg Lab at WEHI in Melbourne. Interested in Ubiquitin ligases, protein structures, and drug discovery. Views my own.

[LechtenbergLab @LechtenbergLab]

Excited to share our latest preprint on @biorxivpreprint: "The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro".

https://t.co/F07r55cMzz

[LechtenbergLab @LechtenbergLab]

We are still accepting abstracts for selected short talks and posters. The abstract deadline has been extended to this Friday, 1st Aug. More information and registration here: https://t.co/tePJ5xnoHl .

[LechtenbergLab @LechtenbergLab]

📣📣 Lorne Ubiquitin – The Australian Ubiquitin Summit 📣📣
20-23 Nov 2025 in Lorne, Australia

Join us this Nov for the first ubiquitin meeting in Australia. Submit your abstract by 18 July 2025 for oral and poster presentations: https://t.co/tePJ5xnoHl
Please share and repost.

[LechtenbergLab @LechtenbergLab]

📣📣 Lorne Ubiquitin – The Australian Ubiquitin Summit 📣📣
20-23 Nov 2025 in Lorne, Australia

Join us this Nov for the first ubiquitin meeting in Australia. Submit your abstract by 18 July 2025 for oral and poster presentations: https://t.co/tePJ5xnoHl
Please share and repost.

[Rashmi Agrata @Rashmi_Agrata]

Australia’s First Ubiquitin Summit is here! 🥳
📍Lorne, Victoria | 🗓️ 20–23 November 2025

Join us on the scenic coastline of Lorne for 4 days of cutting-edge ubiquitin science, featuring a fantastic lineup of international speakers covering all corners of the ubiquitin world

[Michael Lazarou @LazarouLab]

Join us in Lorne for the 11th ISA. We have a fantastic line up of speakers at a beautiful coastal location in Australia. Hope to see you there!

[LechtenbergLab @LechtenbergLab]

We hope this will be useful for the field. A plasmid for expressing the constitutively active HOIL-1 variant is available via @Addgene: https://t.co/M31OYoMvld

[LechtenbergLab @LechtenbergLab]

Excited to share our latest work, now out in @LSAjournal. We show that the E3 ligase HOIL-1 can ubiquitinate many different saccharides and describe a chemoenzymatic platform to generate ubiquitinated sugars as tools for studying non-proteinaceous ubiquitination.

[LifeScienceAlliance @LSAjournal]

The RBR E3 ligase HOIL-1 ubiquitinates Ser/Thr-residues and various disaccharides in vitro and can be used to generate ubiquitinated sugars as tools to study non-proteinaceous ubiquitination @LechtenbergLab @WEHI_research
https://t.co/2geUFE5rtB

[WEHI (Walter and Eliza Hall Institute) @WEHI_research]

World-first: researchers have discovered what protein #PINK1 looks like in humans and how it is activated, solving a decades-long mystery in the fight against #Parkinsonsdisease. The team hope to use the knowledge to find a drug to stop #Parkinsons.

https://t.co/tCFMPARo3Y

[LechtenbergLab @LechtenbergLab]

@lifuyi1991 @nhmrc @SAiGENCI @UniofAdelaide Congratulations Fuyi! Well deserved.

[Madeline E. Kavanagh @mads_chem]

Super excited to be joining @RACInational for #MCCB2025 in Darwin #NT this April!!
#chembiol #drugdiscovery #peptides #ozchem

[Molecular Cell @MolecularCell]

Online Now: Combinatorial mapping of E3 ubiquitin ligases to their target substrates https://t.co/T4aPvUHn08

[LechtenbergLab @LechtenbergLab]

For those wanting to try to ubiquitinating sugars themselves: our plasmid for bacterial expression of the constitutive HOIL-1 variant is now available via Addgene: https://t.co/ikMMgETApK

[LechtenbergLab @LechtenbergLab]

Excited to share our latest preprint on @biorxivpreprint: "The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro".

https://t.co/F07r55cMzz

[Clare Weeden @DrClareWeeden]

I am looking for a research assistant to join my new lab in Melbourne, Australia at WEHI. Please apply at the link below!

https://t.co/YARjYowiHt

[WEHI (Walter and Eliza Hall Institute) @WEHI_research]

Just announced by WEHI, Sir Gus and the Nossal family: the Sir Gustav Nossal Professor of Immunology. This prestigious new position will lead pivotal research to advance human immunology. Made possible by a generous gift from the Nossal family.
Read more: https://t.co/gNqpYptQJJ

[LechtenbergLab @LechtenbergLab]

Thanks to first author @xiangyi_susie, all members of my lab as well as collaborators and co-authors in the @komander_lab (@WEHI_research), @ethangbaus (WEHI) and @PayneResearch (@Sydney_Uni) labs.

https://t.co/F07r55cMzz

[LechtenbergLab @LechtenbergLab]

Excited to share our latest preprint on @biorxivpreprint: "The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro".

https://t.co/F07r55cMzz

[LechtenbergLab @LechtenbergLab]

We hope that our protocol will enable us and others to generate various ubiquitinated saccharides as tools to further develop the non-proteinaceous ubiquitin field. A plasmid for bacterial expression of the HOIL-1 variant will be available at @Addgene soon.

[LechtenbergLab @LechtenbergLab]

@WilflingLab @DGZ_info Well done, Konrad. Congratulations