Jay Bradner, M.D.

Physician-scientist making medicines with friends, memories with family. EVP R&D at Amgen

[Jay Bradner, M.D. @jaybradner]

Jon Clardy was a brilliant scholar and a wonderful man, beloved uniformly in chemistry and chemical biology from Boston to Brazil. My sincerest condolences to those who were lucky to know him well, as mentees and close friends. RIP, Jon, just cannot believe you are gone.

[Michael Fischbach @mfgrp]

Jon Clardy: 1943-2026
One of the most impactful, creative, and (quietly) irreverent practitioners of chemical biology. Transformed how we think about nature's chemicals: their structures, their role in biology. Loved him -- he had tremendous influence on my thinking.

[Jay Bradner, M.D. @jaybradner]

@DrChoueiri @OncoAlert @myESMO @DanaFarber @sands_jacob Thank you, Toni, for sharing this video. We are overjoyed by this result.

[Jay Bradner, M.D. @jaybradner]

Very sad to lose Mike Ditka. He was one of my Father’s true heroes, and running into him at Nite N Gale’s restaurant in Highwood, IL, was as close as what we had growing up in suburban Chicago to meeting a celebrity. Having met a few more now, it was in fact much bigger. A giant presence, personality and commitment to our city. Rest easy, Coach.
https://t.co/bRjanxDOa9

[Jay Bradner, M.D. @jaybradner]

@VincentRK @MyelomaTeacher Ken’s decency knows no boundaries.

[Stand Up To Cancer @SU2C]

#StandUpToCancer has joined forces with @MrBeast and @BeastPhilanthr to create a new SU2C Pediatric Cancer Dream Team focused on finding cures for kids with cancer, fueled by support from @Amgen and @StBaldricks. 🧡✨​

1 in 5 children who are diagnosed with cancer will lose their lives to it. YOU can help change that. Donate today to help find cures at https://t.co/Umeh6fteHR.

[Jay Bradner, M.D. @jaybradner]

Had the chance to spend time with Jimmy Donaldson (@MrBeast) talking about something that's often invisible: the research behind every breakthrough for children with cancer.

Thank you @SU2C for being such an incredible collaborator on this campaign.

Watch the video: https://t.co/NzKK6fuIzw

#mycompany

[Jay Bradner, M.D. @jaybradner]

Very compelling mechanistic rationale for targeting the Fanconi and NHEJ pathways in Ewing Sarcoma. Figure 7 is impressive wrt Indusilam activity in models (RBM39 degradation). If therapeutic index exists or can be engendered, could be interesting. Enjoyed this study thoroughly.

[Dana-Farber News @DanaFarberNews]

New research from Alan D’Andrea, MD published in @MolecularCell reveals that Ewing Sarcoma has a profound DNA repair defect, making it a strong candidate for targeted therapy.

https://t.co/3QR58aoYWx

[Jay Bradner, M.D. @jaybradner]

@JMaraganore Congratulations!

[Jay Bradner, M.D. @jaybradner]

All in the Simi Valley area and neighboring communities, please take note of this new Sandy Fire and wind patterns. Stay safe and take best care.

[KTLA 5 Morning News @KTLAMorningNews]

#BREAKING:
Fire crews are currently battling a brush fire in Simi Valley. @LAflyingcameras overhead NOW.
Tune in to KTLA 5 or stream via the KTLA app 📲, KTLA+ 💻 or https://t.co/ZUpFyKxkKK

[Jay Bradner, M.D. @jaybradner]

ICYMI. Singer and guitarist @ericchurch at UNC Commencement. Reflective, touching, deeply affecting. Will be watching this again with Jennifer and the kids.

[Jay Bradner, M.D. @jaybradner]

Parked right next to it at the Waxahatchee & MJ Lenderman show last evening in LA. IYKYK, respect the total commitment. Incredible performance by @MarkJLenderman @k_crutchfield @waxa_katie

[Jay Bradner, M.D. @jaybradner]

@wgibson @TaaviNeklesa Thanks for the quick and kind note. Wish I could be that guy but tied up with therapeutics. The GOAT of Kac proteomics is Prof. Chuna Choudhary at Univ Copenhagen. But can always IP-IB try using a polyclonal Kac mAb. Great paper, Will!

[Jay Bradner, M.D. @jaybradner]

Very nice study by @wgibson, on bifunctionals in gene control. The EWS-FLI1 signature impact of the JQ1-based recruiter is nice. Worth studying the AR-binding JQ1 ligands from Halda/JNJ, in this way. Contribution of RIPTAC and TCIP components would be very interesting. (Also curious if the potent aTAG-2 acetylates EWS-FLI1 or the chimeric FKBP12). Great read, Will!

[William Gibson @wgibson]

What if a small molecule could activate a transcription factor program in one cell type and destroy the same pathway in another? In our new preprint, we describe one such story on bifunctional molecules that toggle between transactivation and repression.

[William Gibson @wgibson]

What if a small molecule could activate a transcription factor program in one cell type and destroy the same pathway in another? In our new preprint, we describe one such story on bifunctional molecules that toggle between transactivation and repression.

[Jay Bradner, M.D. @jaybradner]

Telomeres are longer on the West Coast. Been in SoCal for only eight months and can already feel it. Nice GWAS on leukocyte telomere length and genetic associations in @NatureGenet by @pnatarajanmd and colleagues. https://t.co/Rm0uadOjWh

[Jay Bradner, M.D. @jaybradner]

@bherzbergmd @CentralParkWMD @NEJM @CpcrMsk @MSK_DeptOfMed @PanCAN @letswinpc @lustgartenfdn @CD_AACR @NatPancFdn @anup_kasi @MeredithPelster @jordanberlin5 @HollebecqueA @do_phd @MacarullaTeresa Anything for @columbiacancer and the @bherzbergmd lab!

[Jay Bradner, M.D. @jaybradner]

@CentralParkWMD @NEJM @CpcrMsk @MSK_DeptOfMed @PanCAN @letswinpc @lustgartenfdn @CD_AACR @NatPancFdn @anup_kasi @bherzbergmd @MeredithPelster @jordanberlin5 @HollebecqueA @do_phd @MacarullaTeresa Very interesting. Would have expected a mutant selective degrader to be much better tolerated. Infusion reactions are uncommon for targeted therapies. Is the VHL engaging feature a challenge? Perhaps a peptidyl feature or solubilizing excipient is provoking an immune reaction?

[Jay Bradner, M.D. @jaybradner]

Learned today of the passing of Phil Low, a drug hunter, scholar, educator and just lovely man. His work to target cancer cells via folic acid receptors, among so many other creative ideas, were a source of inspiration so many years ago. It was an honor to work with him on PSMA radioligand therapy, and to develop his inventions further to real medicines while at Novartis. Phil was a dynamo in his Purdue laboratory, surrounded by adoring trainees, at a whiteboard or pounding through 80 packed Powerpoint slides in 30 breathless minutes. I am glad and better to have known you, Phil. Your memory is a blessing. https://t.co/m4QM2OAih4