Excited to share our new study in Cell Host & Microbe!
We show that bacteria in human saliva and the small intestine can metabolize peanut allergens, reducing IgE binding and anaphylaxis.
Patients with higher peanut tolerance harbor more of these microbes. 1/2
Microbiota impact peanut allergy
Saliva & jejunum harbor peanut-degrading bacteria(Rothia) that metabolize immunodominant PN allergens. Mice colonized w/Rothia show ⬇️anaphylaxis & allergic patients w/better PN tolerance have ⬆️abundance of these bacteria
https://t.co/4J4ZhsHOY7
Excited to share our new study in Cell Host & Microbe!
We show that bacteria in human saliva and the small intestine can metabolize peanut allergens, reducing IgE binding and anaphylaxis.
Patients with higher peanut tolerance harbor more of these microbes. 1/2
Microbiota impact peanut allergy
Saliva & jejunum harbor peanut-degrading bacteria(Rothia) that metabolize immunodominant PN allergens. Mice colonized w/Rothia show ⬇️anaphylaxis & allergic patients w/better PN tolerance have ⬆️abundance of these bacteria
https://t.co/4J4ZhsHOY7
Microbiota impact peanut allergy
Saliva & jejunum harbor peanut-degrading bacteria(Rothia) that metabolize immunodominant PN allergens. Mice colonized w/Rothia show ⬇️anaphylaxis & allergic patients w/better PN tolerance have ⬆️abundance of these bacteria
https://t.co/4J4ZhsHOY7
Congrats to Dr. @LiamERondeau from @LabCaminero for winning the Junior Investigator Award! 🦠
Tryptophan is an essential amino acid found in protein-rich foods and cruciferous vegetables 🥦. Dr. Rondeau highlighted the protective role of microbial tryptophan metabolism in mouse models of IBD, with potential applications in dietary interventions in IBD care.
#IBDMinds2025
🧪NEW PAPER ALERT🧪
Check out our paper in Gut Microbes that sheds light on the role of proteolytic bacteria in inciting inflammation during #colitis, led by @LiamERondeau, the lab's first grad student @FarncombeGI @McMasterU#IBD
Check it out here👇
https://t.co/M6KPaVDnTL
(⅕)
Using gnotobiotic and conventional mouse models, we demonstrate that proteolytic microbes that activate PAR2 expand during inflammation, thus worsening colitis through a PAR2-mediated feedback loop. (⅘)
We found Waldo at our Farncombe journal club's Halloween event / team building session where we discussed the consequences of academic dishonesty and data manipulation #spookyscience
Check out our bake sale in support of the Crohn's and Colitis Canada #GUTSYWALK
Where: McMaster HSC 3rd floor atrium, blue section
When: Tues May 31st 10am
Why: To support those living with #IBD
Lots of yummy treats and coffee ☕️🍪🧁
@getgutsycanada@GutsyWalk@machealthsci
Our lab is recruiting highly motivated graduate students (MSc or PhD)! Check out our research on our website https://t.co/NN4audoGHo and reach out if you are interested in being apart of our team. @AlbertoCaminer7