Perlson lab

🔬 Molecular Neurodegeneration research group at Tel Aviv University, Israel

[Perlson lab @LabPerlson]

In our recent paper we show that TDP43 mislocalization and condensates in axons and neuromuscular junction cause Neurodegenration in ALS by inhibiting local synthesis of mitochondrial proteins https://t.co/sx5O45BY5Z

[Jennifer Trowbridge @TrowbridgeLab]

The Jackson Laboratory is a wonderful, collaborative place to pursue basic & translational science. On the faculty job market? I strongly encourage you to consider joining us in Bar Harbor, Maine!
Apply: https://t.co/blNIfvWMNG
#JAXresearch #JAXstemcellsdev

[ShorterLab @ShorterLab]

Prevention of Unc13a cryptic splicing is sufficient to preserve memory: https://t.co/ti1hksXE7F

[Brain @Brain1878]

Ellis et al. show that cellular stress downregulates the ALS-associated protein STMN2 through impaired translation and stress granule-mediated mechanisms independently of TDP-43 dysfunction. https://t.co/pY196GZc9p

[ShorterLab @ShorterLab]

RANBP17 Overexpression Restores Nucleocytoplasmic Transport and Ameliorates Neurodevelopment in Induced DYT1 Dystonia Motor Neurons https://t.co/g2g46r9nuN

[JAMA @JAMA_current]

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive weakness due to degeneration of upper motor neurons in the brain and lower motor neurons in the brainstem and spinal cord.

Learn more in this Review: https://t.co/nTf7K6bkIn

[Pabi Sahoo (ପବିତ୍ର ସାହୁ) @SahooLab]

Proteolytic cleavage of G3BP1 by calpain 1 couples NMDAR activation to mTOR-dependent local translation | EMBO Reports | Springer Nature Link https://t.co/bSpwMQzZvn

[ShorterLab @ShorterLab]

Small heat shock proteins HspB1 and HspB5 differentially alter the condensation and aggregation of the TDP‐43 low‐complexity domain - Walker - 2026 - Protein Science - Wiley Online Library https://t.co/F1aV6jC5Hq

[Brain @Brain1878]

Mecca et al. investigate the role of muscle stem cells in SMA and show that their depletion disrupts neuromuscular junctions and leads to motor neuron loss in the spinal cord. They conclude that muscle stem cells represent potential therapeutic targets. https://t.co/wWcg0eoby2

[Rothstein Lab @Rothstein_Lab]

Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons
https://t.co/QstZweEHR2

[Rothstein Lab @Rothstein_Lab]

Neuron subtypes have distinct mitochondrial transport in axons and vulnerability to tau in vivo
https://t.co/rUDywnnNcZ

[ShorterLab @ShorterLab]

Annexin A7 enhances TIA1 axonal trafficking to counteract pathological aggregation in neurons | The EMBO Journal https://t.co/E1ojarRDyJ

[bioRxiv Neuroscience @biorxiv_neursci]

KIF5A binds RNA to orchestrate synaptic mRNA localization and stress granules in ALS https://t.co/2cFTW76GdX #biorxiv_neursci

[ShorterLab @ShorterLab]

Cell size-dependent mRNA transcription drives proteome remodeling https://t.co/Zlvz9uw4jJ

[Pabi Sahoo (ପବିତ୍ର ସାହୁ) @SahooLab]

Read this excellent story from the @jltwiss1 lab. Acetylation of Axonal G3BP1 through ELP3 Accelerates Axon Regeneration https://t.co/5TOcPagj3o

[Brain @Brain1878]

O'Brien et al. demonstrate a link between ALS and extreme exercise in males which is potentially mediated via failed mTOR signalling at the neuromuscular junction. https://t.co/SpCnO3xKey; https://t.co/Z2ONeJPjaR

[Neural Cell News @NeuralCell]

Drs. Yi Zeng, Aaron Gitler, and colleagues show that loss of TDP-43 from neuronal nuclei of human brain and disease-causing mutations in TDP-43 are associated with widespread changes in alternative polyadenylation. 🧠 @StanfordMed

@NatureNeuro | https://t.co/3LtW0oV4PU

[ShorterLab @ShorterLab]

Retrotransposons unplugged: Rewiring the nervous system and wreaking havoc: Neuron https://t.co/GiMB1Trsah

[ShorterLab @ShorterLab]

Synaptic changes contribute to persistent extra-motor behaviour deficits in the rNLS8 TDP-43 mouse model of amyotrophic lateral sclerosis: https://t.co/AWC6Rk6niD

[Perlson lab @LabPerlson]

Our cover art suggestion. Firefighters spraying mir126 balloons to douse the flames- toxic TDP-43 aggregates that damage axons and neuromuscular junction in ALS. Illustration by Maayan Visuals. https://t.co/FMksQim7eF

[Perlson lab @LabPerlson]

By uncovering a new mechanism that drives ALS progression and identifies a potential therapeutic target, we hope this work opens up new avenues for intervention.

Grateful to my brilliant team and collaborators for making this possible.

[Perlson lab @LabPerlson]

Thrilled to share our new work in Nature Neuroscience!

Together with amazing collaborators and led by Ariel Ionescu, we discovered that muscle-derived miR-126 controls local axonal TDP-43 synthesis and protects neuromuscular junctions in ALS.

https://t.co/FMksQim7eF