ShorterLab

Countering deleterious phase transitions in ALS/FTD, PD, AD, and related disorders @Penn @PennMedicine @bb_upenn @BMBGGUPENN @PGGUPenn @PennNGG @CAMBUpenn

[ShorterLab @ShorterLab]

UTR-ly unexpected: RNA chaperones tame intrinsically disordered proteins: Cell https://t.co/LBbmPZeqOI

[ShorterLab @ShorterLab]

DDX3X syndrome mutations lock DDX3X-RNA conformational states to drive persistent pathological condensation and neuronal death: https://t.co/EB8gJuCH1B

[ShorterLab @ShorterLab]

Human spinal interneurons repair the injured rat spinal cord through synaptic integration | Science Translational Medicine https://t.co/HW1KQRZyxc

[ShorterLab @ShorterLab]

An ancient mitochondrial program tunes translation to haem availability: https://t.co/lkljHLExD2

[ShorterLab @ShorterLab]

Tunneling nanotubes in the nervous system: The fourth pillar of brain connectivity: Neuron https://t.co/3mRdQV1J6f

[ShorterLab @ShorterLab]

Mitochondria and brain aging: From cell-specific dysfunction to intercellular cooperation: Neuron https://t.co/Hs4g06m1sL

[Brunet Lab @BrunetLab]

Excited to see our new paper published in @eLife!

https://t.co/mRpqBJGRWy

Huge congratulations to Rahul Nagvekar and team @Ravi__Nath and @clairebedbrook!! 🙌✨

We identify brain macrophages that engulf extracellular material in the aging #killifish brain!

[ShorterLab @ShorterLab]

The folding, dimerization and allosteric landscapes of the ALS protein SOD1: a comprehensive mutational atlas: https://t.co/pP5zl3gsaQ

[Alzforum @alzforum]

Despite an amyloid burden on par with Alzheimer's disease, many centenarians keep tau tangles at bay. Which proteins help them do that? @amsterdamunc https://t.co/ONiDEP7awW

[Philadelphia Phillies @Phillies]

Arraez and shine

[ShorterLab @ShorterLab]

Susceptibility and regulation of biomolecular condensates by solutes | PNAS https://t.co/D5mIbSLhYA

[ShorterLab @ShorterLab]

Dynamic principles of concentration buffering through liquid–liquid phase separation | PNAS https://t.co/8YbfXfvdzh

[ShorterLab @ShorterLab]

Evolution on degenerate fitness landscapes is not random: Curvature drives directional drift | PNAS https://t.co/Pxe0vlD8Vn

[ShorterLab @ShorterLab]

The chaperone Jjj2 regulates nucleoporin condensation in budding yeast https://t.co/v41knPPbHG

[ShorterLab @ShorterLab]

Torsins organize CLCC1 assembly to safeguard ER bilayer and lipid homeostasis: Molecular Cell https://t.co/4Lcx8dJaHV

[ShorterLab @ShorterLab]

The dystonia-associated Torsin1A sustains CLCC1 function in membrane fusion of the nuclear envelope for NPC biogenesis: Molecular Cell https://t.co/N2IdIp8Vld

[ShorterLab @ShorterLab]

Distinct cellular phenotypes of language and executive decline in amyotrophic lateral sclerosis: Cell https://t.co/NdGMpBhkMe

[Philadelphia Phillies @Phillies]

Flipped the script

[ShorterLab @ShorterLab]

A first-in-class RNA degrader reduces c-MYC expression and myeloma cell survival in preclinical models: https://t.co/HlU08hxSsr

[ShorterLab @ShorterLab]

PARP1 hyperactivity stalls translation and triggers stress granule formation following DNA damage: https://t.co/gtQHQYP43B

[Ben Lehner @BenLehner]

Complete Mutagenesis of the Genome and Proteome of ΦX174. 1st genome sequenced (Sanger 1977), 1st genome
synthesised (Venter 2003), first genome + proteome fully mutated (@huijin6418 and @XianghuaLi2 2026) @CRGenomica @sangerinstitute
https://t.co/4I0chjORkW