Synthetic Physiology Lab

This is the twitter profile of @fspasqualini's Synthetic Physiology Lab at the University of Pavia. Website:

[Eloisa Torchia @eloisa_torchia]

Throughout my PhD and now as a postdoc, the starting point has often been the bottom of a culture well. @fspasqualini and I bring that perspective to our new review in Biophysics Reviews.

[Synthetic Physiology Lab @LabPhysiology]

@LabPhysiology @unipv

[Francesco Pasqualini @fspasqualini]

Bioengineering's gift to AI isn't another algorithm. It's more life-like cell cultures to learn from.

LigHTS, now out in Advanced Science, makes soft, microstructured hydrogels directly in standard 1536-well plates, every well in a single 16-min light exposure. 🧵

[Synthetic Physiology Lab @LabPhysiology]

@LabPhysiology @unipv

[Francesco Pasqualini @fspasqualini]

It's built for data production. Across 100+ wells, thickness varies by less than 15% and groove pitch by about 1%. Imaging stays sharp at 100x, and 1–10 ms label-free holographic QC checks every well's substrate before it becomes training data.

[Francesco Pasqualini @fspasqualini]

‘Proliferation’ — @LabPhysiology 's artist-in-residence @Pe3lliMartina & Alessandro “Choxee” Ciociola.
 At #SUPERHOST (Cisternino): an interactive mirror that weaves your image into a golden spiral + cell microscopy. Art + science meet: from illustration to provocative parallels (cancer vs over-tourism). Info: https://t.co/Bblyw4A07L

[Synthetic Physiology Lab @LabPhysiology]

@BiophysRev & @AIP_Publishing now accept peer‑reviewed #Visuals—image‑centric articles where the artwork is the result. I lay out the vision in my editorial: https://t.co/f1GLGYhZQ1. Ready to publish your #SciArt?

[Synthetic Physiology Lab @LabPhysiology]

🎨 New @LabPhysiology logo drop! Crafted by @Pe3lliMartina. Big thanks to @Kkitparker & Michael Rosnach for sparking our art‑science journey at the Harvard DBG. Process PDF attached. See it live ➡️ https://t.co/gqxtsjBvbp

[Francesco Pasqualini @fspasqualini]

🚀 CALIPERS v2 preprint is locked—journal submission next. Final polish, more hiPSC reference lines, and fresh light-sheet data. Still, a great collaboration led by @moisesdisante with the team @LabPhysiology and the amazing @berteroale and @florianjug group members!

https://t.co/XDUKMdZap6

[Reto Fiolka @RetoPaul]

The MOSAIC reconfigurable microscope by @Eric_Betzig et al is finally out!

MOSAIC integrates multiple advanced imaging techniques including light-sheet, label-free, super-resolution, and multi-photon, all equipped with adaptive optics:
https://t.co/RkwkoptVHv

[Synthetic Physiology Lab @LabPhysiology]

2. Combining hydrogels with high throughput screening? Easy, with HYDRA!! https://t.co/be4TRX9gDJ

[Francesco Pasqualini @fspasqualini]

And here is pre-print 2/2 before the end of the year! *HYDRA: HYdrogel Dispensing with Robotic Automation* - a scalable solution for drug testing. Great work by @eloisa_torchia, her team @LabPhysiology and the labs of @SylvainGabriele @CimettaLab and Lind https://t.co/7KADEJczav

[Synthetic Physiology Lab @LabPhysiology]

Preprints from the lab stemming from our @ERC_Research project #SYNBIO.ECM @unipv

1. Combining FUCCI with live cell phenotypic? Introducing CALIPERS

[Francesco Pasqualini @fspasqualini]

1/2 pre-prints to end the year! @LabPhysiology is happy to present *CALIPERS: Cell cycle-Aware Live Imaging for Phenotyping Experiments and Regeneration Studies* led by @moisesdisante and in collaboration with the amazing @berteroale and @florianjug labs https://t.co/54Gn6ao1v6

[Francesco Pasqualini @fspasqualini]

My Synthetic Physiology Laboratory at the University of Pavia (Italy, ~30 mins from Milan) is opening an ERC-funded, two-year mechanobiology post-doctoral position.

Lab link: https://t.co/NO6tjj61Ry

1/10

[Synthetic Physiology Lab @LabPhysiology]

We are looking for an expert in traction force microscopy (TFM) to work on human induced pluripotent stem cells in our ERC-funded project SYNBIO.ECM.

Ideal candidates have extensive TFM experience in their PhD, but exceptional appointments can be made for PhD or instructors.

[Francesco Pasqualini @fspasqualini]

Equipment and people are rolling in, microscopes and cells next month --> COVID has slowed us down but hasn't beaten us!

@ERC_Research lab @unipv looking for postdocs in #TFM, #Organoid, and/or #MicroscopeBuilding. DM if interested. RT appreciated.