Gottardi Lab

We study the multiple functions of catenins in cell-cell adhesion, cytoskeleton/nuclear signaling and lung repair after injury

[J Cell Science @J_Cell_Sci]

Divide and conquer: cytokinesis builds the zebrafish left–right organizer

Yiling Lan, Yan Wu, Heidi Hehnly & colleagues dissect how junctional scaffolds and cytoskeletal networks support KV development.

Highlight: https://t.co/ovSfkcNDL2
Article: https://t.co/QaZrypedIT

[Journal of Cell Biology @JCellBiol]

Our November issue is here! https://t.co/CBDvFj2bnK
🔬 The cover shows a live L4-stage #Celegans showing the small GTPase RAL-1 (red), the elaborate dendritic arbor of PVD mechanosensory neurons (green), and epithelial nuclei (blue). From Wu and Reiner: https://t.co/TyhXD2PRFO

[Rockefeller University @RockefellerUniv]

The field of cell biology was born at Rockefeller thanks to Albert Claude, George Palade, and Christian de Duve, who shared the 1974 @NobelPrize for their discoveries on the structural and functional orga­nization of the cell. #125YearsofRockefeller

[Rogan Grant @RoganAGrant]

Excited to be named a 2026 Toffler Scholar! Many thanks to the Karen Toffler Charitable Trust for their generous support. Looking forward to sharing what we learn!

[Toffler Trust @TofflerTrust]

Meet @RoganAGrant , one of the 2026 Toffler Scholars.

Rogan, a postdoctoral fellow at @NorthwesternU , is asking:
What can people who age with exceptional memory teach us about resistance to neuroinflammation?

Follow Rogan’s work at https://t.co/u2ojFjUvoj.

[Noboru Ishiyama @xtalmountain]

His doctors gave him 2 or 3 months. A new early-stage Toronto cancer treatment, invikafusp alfa (a first-in-class, bispecific, dual T cell agonistic antibody), has been a 'lifesaver' https://t.co/q3DV0V9Wg9 via @torontostar

[Cell Biology J-Club @cell_club]

Mechanically induced septin networks protect nuclear integrity https://t.co/NTjXgecXSd

[Journal of Cell Biology @JCellBiol]

New work by Faria, Janody et al. @i3S_UPorto reveals that P-#cadherin engagement and FAK activate mechanosensitive proliferation in premalignant Src-activated cells, highlighting a key role for adhesion-mediated signaling before malignant progression. https://t.co/MsIA549Ls3

[Kourtidis Lab @AntoniKourtidis]

On November 7, we are riding with @lowvelo across #Charlestonsc #lowcountry #SouthCarolina to beat cancer! 100% of donations support life-saving cancer research at @muschollings @MUSChealth. To learn more, visit our fundraiser and support our research now: https://t.co/tbYBnwSGxT

[Gottardi Lab @GottardiLab]

@HJRBio Great question. #Afadin is a multi-domain protein with 'other ways' to localize to apical junctions (e.g., nectins, ZO-1...). Stay tuned for a related paper on this very point!

[Gottardi Lab @GottardiLab]

NEW PAPER: How do we make resilient #epithelial barriers? We find that a key #mechanosensitive protein relies on force-dependent unfolding AND phosphorylation to recruit effectors that progressively build #cell-cell junctions. A 🧵: 1/11 https://t.co/Shq62uP54Y

[Gottardi Lab @GottardiLab]

Hearty congrats 🎉 to #NUMSTP and #DGP first-author @j_quinn_edu, who wrote #FIJImacros and re-learned #neuroanatomy 💪 to characterize the 🐀 🧠 defect (among other things)! 11/11

[Gottardi Lab @GottardiLab]

So we reason that alpha-catenin relies on #dual-inputs... mechanical unfolding AND chemical modification to jiggle itself and other partners like #Afadin into packed junction structures. 10/11