Noboru Ishiyama

Structural biologist with interests in cancer therapeutics, big data science & molecular art! Tweets are my own.

[Noboru Ishiyama @xtalmountain]

@GottardiLab @pmresearch Congratulations, Cara and team @GottardiLab as well as wonderful collaborators!

[Noboru Ishiyama @xtalmountain]

This cancer drug is saving lives. It's also threatening to break Canadian health-care budgets https://t.co/vcrYE4qa01 via @torontostar #medicine #cancer #healthcare

[André Picard @picardonhealth]

The challenge of whether or not to fund promising new drugs. It’s not enough for a treatment to work, it has to work well and provide value for money, by @picardonhealth https://t.co/8ZUuFTMQcL via @GlobeDebate

[Madeleine Armstrong @ByMadeleineA]

Servier bags a Black Diamond in the rough. My quick take on today's $BDTX deal via @ApexOnco https://t.co/2cAXGAVimL

[Noboru Ishiyama @xtalmountain]

@GottardiLab Congratulations @GottardiLab, co-authors and collaborators! These a-cat mutation-induced cytokinesis failure movies are always intriguing and mesmerizing to watch! Dynamic regulation of cellular force/adhesion is so important!

[Gottardi Lab @GottardiLab]

AT LONG LAST… The essential #adherensjunction mechanosensitive protein alpha-catenin is required for #cytokinesis fidelity. We credential a previously defined (but poorly understood) abscission factor in this process, LZTS2. 🧵1/12 https://t.co/tUicleRZ4M

[Rockefeller U. Press @RockUPress]

In @JCellBiol, Wang, Yemelyanov et al. @GottardiLab @NorthwesternMed find that the force-sensitive cell-cell #adhesion component alpha-catenin is required for #cytokinesis fidelity through LZTS2. https://t.co/t55WWIbtmJ

@PMResearch_UHN @xtalmountain @gingraslab1
#CellDivision

[Journal of Cell Biology @JCellBiol]

Wang, Yemelyanov et al. @GottardiLab @NorthwesternMed find that the force-sensitive cell-cell #adhesion component alpha-catenin is required for #cytokinesis fidelity through LZTS2. https://t.co/4kajkub2SY

@PMResearch_UHN @xtalmountain @gingraslab1
#CellDivision

[Simon Duerr @simonduerr]

There is a new tool on BioIcons to turn any protein (in PDB format) into a 2D vector illustration in SVG format. You can upload any PDB file or import from PDB, AlphaFoldDB or ESMFoldDB. Feedback welcome :)
https://t.co/grMysO8JV5

[Noboru Ishiyama @xtalmountain]

Latest from Congruence Tx: https://t.co/eIEqpxOS9O

[Noboru Ishiyama @xtalmountain]

Revolution, interrupted: Why AI has failed to live up to the hype in drug development /via @globeandmail https://t.co/6rcn1zQda9

[Noboru Ishiyama @xtalmountain]

"A drug molecule needs to bind to a protein in order to treat disease, and finding a match is a ridiculously complicated problem, in part because proteins can assume different shapes and structures. ... AI is of little help."

[Noboru Ishiyama @xtalmountain]

How Jim Carrey helped Raptors icon DeMar DeRozan face depression https://t.co/EXCBS5c2bp via @torontostar

[Oxford Protein Informatics Group (OPIG) @OPIGlets]

OPIG DPhil student @GemmaLGordon led work to build and analyse "PLAbDab-nano: a database of camelid and shark nanobodies from patents and the literature". Just released on bioRxiv and available as an OPIG webapp:

Preprint: https://t.co/OzbefvcyKB
Webapp: https://t.co/5yvBJ4IRyn

[Yoshitaka Moriwaki @Ag_smith]

🎉 New formula Coot 1.1.09 in Brewsci/bio for Linux and macOS!
ℹ️ Crystallographic Object-Oriented Toolkit
🍺 brew install brewsci/bio/coot
#Bioinformatics

[Noboru Ishiyama @xtalmountain]

https://t.co/Gaz2XfkdQR

[Lorenzo Casalino @LCasalino88]

In 2018, I started my journey at @RommieAmaro's lab working on mesoscale simulations of influenza virus. After ~5 years in the making, I'm happy to share that the paper is now published in @ACSCentSci!

https://t.co/nSinT0USTN

Instead of a 🧵, I made a trailer 🎞️🎥! Sound ON 🔊

[Noboru Ishiyama @xtalmountain]

Here is how you can add protein structures from PyMOL as interactive 3D models in PowerPoint: 1) In PyMOL, export VRML2 file. 2) Convert file from VRML2 to glTF format in Blender. 3) Insert as 3D model in PowerPoint. That's it! For more info: https://t.co/hsqjjGWxnV

[Noboru Ishiyama @xtalmountain]

@GottardiLab Another compelling and beautiful preprint from @GottardiLab on the importance of α-catenin mechanosensitivity and LZTS2 in cytokinesis! Hopefully everyone will get to see the so-close-yet-fails-again cytokinesis movies soon😉 Congrats!

[Gottardi Lab @GottardiLab]

New on BioRxiv: The essential adherens junction mechanosensitive component alpha-catenin is required for cytokinesis fidelity. We also credential a previously defined (but poorly understood) abscission factor in this process, LZTS2.