Poltorak Lab

Twitter for Alexander Poltorak's Lab at Tufts University School of Medicine

[Ivan Zanoni @Lo_Zanzi]

#WeekendRead! #NoTimeToDie! Welcome to a new form of cell death: #efferoptosis! Poltorak, Muendlein &co show @SciImmunology that during systemic inflammation TNF reprograms efferocytic macrophages to activate caspase-8 (not NLRP3!) pyrotosis & IL1b release https://t.co/pPzdpatE2c

[Waggoner Lab @LabWaggoner]

Activation of macrophages engulfing neutrophils by TNF switches efferocytosis to caspase-8–mediated pyroptosis and IL-1β production @SciImmunology @LabPoltorak
https://t.co/gSsLLw9TAD

[Science Immunology @SciImmunology]

Scientists have found that tumor necrosis factor can switch macrophage #efferocytosis from immunologically silent to pro-inflammatory during #sepsis and systemic inflammation. @LabPoltorak

Learn more in Science #Immunology: https://t.co/XmgFOanSCJ

[Abe Bayer, PhD @AbeBayer]

Excited to have contributed to this paper!!! Read here how STING regulates microglia in aging. Congrats to @kate_sulka and the whole team!!! @CellReports

https://t.co/qe7jmoaDl3

[Abe Bayer, PhD @AbeBayer]

Have you seen our papers on T-cell Myd88 in HF and cancer (links in 🧵) and wondered what the mechanism at the TCR was? We now outline a novel molecular role for MyD88 acting downstream of the TCR and regulating activation / cell death, out in @J_Immunol

https://t.co/bWHUzFn1L1

[Abe Bayer, PhD @AbeBayer]

Thank you to @LabPoltorak @ZoieMagri @PilarAlcaidePhD for making this study possible. Previous papers on T-Myd88 at @CircRes (https://t.co/IOi2dsj5X3) and @AJPathology (https://t.co/CaaoFMOQcZ)

[Pilar Alcaide, PhD @PilarAlcaidePhD]

After reporting a role for T cell MyD88 during cardiac adaptation to stress @CircRes & in melanoma @AJPathology, we now decipher a molecular mechanism👇. Thank U @J_Immunol @AbeBayer @LabPoltorak @ZoieMagri @TuftsMedSchool
https://t.co/CGUn7gmQO7

[Ivan Zanoni @Lo_Zanzi]

#EveryCellIsAnImmuneCell!💥Thrilled💥for our new paper @CellCellPress with @achillebro! We show that, during #IBD, type III #interferons delay gut repair by inducing #pyroptosis in intestinal epithelial cells via #gasdermin C upon ZBP1 activation! 1/n https://t.co/d8MxfU5NcB

[Poltorak Lab @LabPoltorak]

An exciting Halloween week for the Poltorak lab! Two successful PhD defenses in one week! Congrats David Jetton and @ZoieMagri ! Big thank you to outside examiners @MichelleKellih3 and @Lo_Zanzi for fabulous discussions! @TuftsGSBS

[Poltorak Lab @LabPoltorak]

It was an exciting August in the Poltorak Lab! #Twisters
@TuftsGSBS @ZoieMagri @CellReports

[Poltorak Lab @LabPoltorak]

We found CD14 can switch Fas signaling from pro-death to pro-inflammatory! Check out our recent work in @CellReports to learn more. Congrats to first author @ZoieMagri!
https://t.co/uo0J6Tk1qg

[Poltorak Lab @LabPoltorak]

How does RIPK1 drive activation of caspase 8 in Yersinia infection?? Read our latest paper in @CellReports to find out! Congrats to first author David Jetton @TuftsGSBS
https://t.co/kxiGI6et5w

[preLights @preLights]

Neurons repurpose death complex components to induce an anti-viral response during Zika virus infection.

In her first preLight, @ZoieMagri covers recent work from the lab of @AndrewOberst. #preprint

#preLight 👉 https://t.co/NJoXro06aW

[Zoie Magri, PhD @ZoieMagri]

A recent preprint from the lab of @AndrewOberst demonstrates that neurons can repurpose death complex components to induce an anti-viral response to Zika!
I’ve highlighted their work in my latest preLights post. Check it out!

https://t.co/V3pvvVtMXA

[American Society for Investigative Pathobiology @ASIPath]

This symposium on #celldeath and survival will discuss exciting developments in this field including inflamed tissues and non-canonical #molecularpathways. Register for #Pathobiology2024 to attend this session! https://t.co/03awtFtBf0

@Penn @TuftsUniversity @NotreDame @YaleMed

[The Conversation U.S. @ConversationUS]

Cell death is essential to your health − an immunologist explains when cells decide to die with a bang or take their quiet leave https://t.co/uBA0RwdcYu

[Poltorak Lab @LabPoltorak]

Check out this piece by one of our PhD students @ZoieMagri in the @ConversationUS !
Cell death is essential to your health − an immunologist explains when cells decide to die with a bang or take their quiet leave https://t.co/C3auT5UPsu

[Kristopher Sarosiek @CellDeathLab]

➡️Join us at the next BCDI meeting on Monday Oct 2nd at 3PM on the Harvard Med Quad (Goldenson 122) for exciting discussions with @chendi on inducing apoptosis in NSCLC and @nabel on identifying novel therapy targets in thymic epithelial tumors. More info: https://t.co/uOJiL13B18

[Dr. Sunny Shin @SunnyShinLab]

Intriguingly, & consistent with the earlier work of @LabPoltorak (https://t.co/SXWdMWJ1kU), Jenna found that unlike in mouse macrophages, WT Yersinia fails to induce cell death in human IECs & macrophages, indicating that human cells are unable to undergo YopJ-mediated death. 4/n

[Kristopher Sarosiek @CellDeathLab]

➡️Join us at the next BCDI meeting on Monday Sept 11th at 3PM on the Harvard Med Quad (Goldenson 122) for exciting discussions led by @TheLeeLab on cell death in response to transcription blockade and @OylerYanivLab on cell death in infections. More info: https://t.co/uOJiL13B18