Rudolf Lab

Natural Products, Biosynthesis, Enzymology, Genome Mining, Bioengineering

[Rudolf Lab @LabRudolf]

The #BJOC thematic issue on Young investigators in natural products chemistry, biosynthesis, and enzymology is now complete! 31 contributions from young investigators around the world! Check it out! @BeilsteinInst https://t.co/a4mYvyDF6x

[Rudolf Lab @LabRudolf]

More exciting biosynthetic work on bacterial #eunicellane #diterpenoids out of the @Helfrich_lab!

[Helfrich Lab @Helfrich_lab]

Our study in ACS Chem Biol reveals a unique eunicellane pathway featuring a reductase fused with a terpene cyclase, a P450 split into 3 fragments and a hypothetical protein with dual isomerase and oxygenase functions!

https://t.co/VmFe45p5ow

[Yi Tang @yitang_ucla]

Checkout the JIMB issue on Natural Products https://t.co/FkXCbbedud
Thank you authors! @marnixmedema @GillesvanWezel Michael Smanski, @BK_KAIST @hanzyduzit @lab_shen Dong-Chan Oh, @EustaquioLab @gerryiidr Hsiao-Ching Lin, Yousong Ding, @LabRudolf @ParkinsonLab and Ikuro Abe!

[Sandra Loesgen (loesgenlab.bsky.social) @LoesgenLab]

New brominated allianthrones with activity against triple negative breast cancer cells and fungal genome analysis! Great work by Paige Mandelare-Ruiz and in collaboration with April Risinger lab and @LabRudolf @Whitney_Lab @UFChemistry https://t.co/0hMZMXGpoH

[Chekan Lab @ChekanLab]

Out now in @Chem_CP , we collaborate with @piel_lab to discover a prenyltransferase+terpene cyclase fusion enzyme that modifies Trp residues in RiPPs to yield complex steroid-like scaffolds! Congrats to @HubrichFlorian, @sanathrajkk0 for leading this!🎉https://t.co/2TGkSQzbfq

[Rudolf Lab @LabRudolf]

Bacteria are talented producers of #diterpenes. We screened 334 terpene synthases: https://t.co/RiV2P4OaXm. New skeletons, new stereoisomers, terpenes known in other organisms but new to bacteria. A massive team effort led by Xiuting Wei and Wenbo Ning! @UFChemistry

[Rudolf Lab @LabRudolf]

A shout out to one of the reviewers for taking the time to look at all of our NMRs and catching an NMR mis-assignment. Thank you! 🙏

[Rudolf Lab @LabRudolf]

It's out! One of @tyler_alsup_'s PhD projects is now published in @rsc_chembio! He used heterologous expression to decipher the first four steps of phenalinolactone #diterpene #biosynthesis. More from Tyler coming soon! https://t.co/J17RLTtjhj

[Rudolf Lab @LabRudolf]

Many thanks to @pharmacognosy and @UF_CLAS for supporting Diana with travel awards!

[Rudolf Lab @LabRudolf]

Excited to see these photos from #ICNPR2024! Congrats to Daniel @dicenhour91 and Diana Łomowska-Keehner for their wonderful presentations on bacterial #terpenes. Thanks for representing us in Poland at #ICNPR2024! @pharmacognosy

[Rudolf Lab @LabRudolf]

Our former postdoc Prof. Baofu Xu and his group just published in @NatureComms on the microeunicellol-type bacterial eunicellane #diterpenoids. Check it out here: https://t.co/ETeaEwX5vE #proudPI Congrats @Baofu_Xu!

[Rudolf Lab @LabRudolf]

@JainLaboratory @LongNgu84547407 @Starlitknight_ @UFLChE @UFWertheim @UFHealthCancer @UF Congrats Piyush! Well deserved!

[Aaron Puri @awpuri]

We are looking for a postdoc!

[Rudolf Lab @LabRudolf]

A bit late, but wanted to share our newest paper in #BJOC on eunicellane #diterpene chemistry. @lizining666 Another fun collaboration with @TantilloLab @LoesgenLab! https://t.co/uWHHSfHSaL

[Rudolf Lab @LabRudolf]

Daniel @dicenhour91 and Diana Łomowska-Keehner representing @rudolflab at @AmerChemSociety #FAME2024! Congrats to both you of for 2 great presentations!

[Shen Lab @lab_shen]

We are excited to finally publish the unprecedented biosynthetic origins of enediyne natural products: iodinated polyynes! This transformative discovery is a huge milestone for these clinical antitumor antibiotics. @Kalkreuter @guichun98 @nchembio
https://t.co/oRDfTcKEkn

[Yi Tang @yitang_ucla]

Early Announcement!
https://t.co/51sBfn27eJ
Together with Brad @BradMoore_SIO, Jaclyn @JMWinterlab, and Alessandra @EustaquioLab,
We look forward to welcoming you to the 2025 @SIMB_Microbio Natural Product meeting at San Diego!
Keynote speaker Prof. Jennifer Doudna! @doudna_lab

[Rudolf Lab @LabRudolf]

We are hiring an NIH-funded postdoc! Looking for a highly motivated researcher with a strong background in natural product isolation and structural characterization for #terpene NP discovery, #biosynthesis, #enzymology. Please RT! @UFChemistry https://t.co/NA2ihugxcs

[Beilstein-Institut @beilstein-institut.bsky.social @BeilsteinInst]

Researchers @Fudan University 🇨🇳 focus on #chemoenzymatic synthesis of macrocyclic peptides and polyketides via #thioesterase-catalyzed #macrocyclization. #biosynthesis
➡️ https://t.co/mRNGaobENu
Thanks for guest editing @LabRudolf, @barra_lena and Takayoshi Awakawa!
💎🔓 #BJOC

[Rudolf Lab @LabRudolf]

@Kalkreuter @ChemistryFsu Congrats @Kalkreuter! Ben just told me the news. Glad to hear you’ll just be up the road at @ChemistryFsu!