SchirmerLab

nuclear envelope, genome organisation, laminopathies,

[SchirmerLab @LabSchirmer]

How is the genome organized in fat tissue? Our new study on #genomeorganisation in #lipodystrophy is published today in @NatureComms. We show that Tmem120a gene knockout in fat leads to lipodystrophy in mice due to disrupting genome organisation in fat https://t.co/fjheYJcEsZ

[SchirmerLab @LabSchirmer]

@JPLab_ @WTcell @GeneCenter_LMU @SBSatEd @LMU_Muenchen @Pragya_Sriv @bethan_medina @Alba_Edinburgh @PaulaSoteloP @ERC_Research @wellcome Excellent news JP! Congratulations!

[One Health Genomics Edinburgh @GenomicsEdi]

New paper:

Enhancers on the edge - how the nuclear envelope
controls gene regulatory elements

@WTcell @mrc_hgu @EdinUni_IGC @RafalEstrella

Read more here: https://t.co/rLzOmWb5px

[SchirmerLab @LabSchirmer]

Happy to share our newest review by Rafal Czapiewski @RafalEstrella In this work we discuss current research on the nuclear envelope control of the 3D genome and especially the regulation of the enhancers and other regulatory elements. https://t.co/dyojHuKjYM

[Andrew Goryachev 🇺🇦 @GoryachevAndrew]

Probably yet the most esthetic project of my entire career... Could I even imagine, some quarter of a century ago, doing my PhD on spiral waves in model chemical equations that I would be studying these intricate wave patterns in a real LIVING biological system!!
Fascinating...

[Douglas Vernimmen @DougVer]

We are hiring a postdoc @EdinburghUni #epigenetics #Edinburgh https://t.co/F5YDrdU1XB

[Douglas Vernimmen @DougVer]

We are back @EdinEpigenetics Seminars with @Hannah_K_Long @mrc_hgu @RafalEstrella @SBSatEd @crm_edinburgh

[Dr Rafal Czapiewski @RafalEstrella]

Interested in nucleus size in cancer and how to target it with old drugs? Check the latest from @LabSchirmer published today! https://t.co/Ze29R16p1x

[SchirmerLab @LabSchirmer]

Check out our latest research on targeting cancer cell nucleus with old drugs! https://t.co/FcL8nwEbYO

[Dr Rafal Czapiewski @RafalEstrella]

breaking news!
Discovery could hold the key to alleviating metabolic disease https://t.co/Ok32cst3OL

[SchirmerLab @LabSchirmer]

6. Finally, we see regulatory miRNAs also changed by genome organization disruption, arguing that injection of miRNAs could be used therapeutically and/ or simply used by athletes to gain muscle mass.

[SchirmerLab @LabSchirmer]

How is the genome organized in fat tissue? Our new study on #genomeorganisation in #lipodystrophy is published today in @NatureComms. We show that Tmem120a gene knockout in fat leads to lipodystrophy in mice due to disrupting genome organisation in fat https://t.co/fjheYJcEsZ

[SchirmerLab @LabSchirmer]

5. We see genes are also spatially disorganized in #musculardystrophy.

[Dr Rafal Czapiewski @RafalEstrella]

When email from the editor starts with "We are delighted to..."

[Biological Sciences | University of Edinburgh @SBSatEd]

#PostdocAppreciationWeek 🧑‍🔬🌟

@RafalEstrella from Eric Schirmer's lab studies rare diseases caused by mutations in genes coding for proteins of nuclear lamina with a focus on #lipodystrophy and #musculardystrophy

➡️ https://t.co/4BanfPWXAj

#NPAW2021 @UK_NPAW

[SchirmerLab @LabSchirmer]

Congratulations to Chalres Dixon from @LabSchirmer for his STING paper. Its online today:
https://t.co/UDcI5KJCLr