How is the genome organized in fat tissue? Our new study on #genomeorganisation in #lipodystrophy is published today in @NatureComms. We show that Tmem120a gene knockout in fat leads to lipodystrophy in mice due to disrupting genome organisation in fat https://t.co/fjheYJcEsZ
New paper:
Enhancers on the edge - how the nuclear envelope
controls gene regulatory elements
@WTcell @mrc_hgu@EdinUni_IGC@RafalEstrella
Read more here: https://t.co/rLzOmWb5px
Happy to share our newest review by Rafal Czapiewski @RafalEstrella In this work we discuss current research on the nuclear envelope control of the 3D genome and especially the regulation of the enhancers and other regulatory elements. https://t.co/dyojHuKjYM
Probably yet the most esthetic project of my entire career... Could I even imagine, some quarter of a century ago, doing my PhD on spiral waves in model chemical equations that I would be studying these intricate wave patterns in a real LIVING biological system!!
Fascinating...
6. Finally, we see regulatory miRNAs also changed by genome organization disruption, arguing that injection of miRNAs could be used therapeutically and/ or simply used by athletes to gain muscle mass.
How is the genome organized in fat tissue? Our new study on #genomeorganisation in #lipodystrophy is published today in @NatureComms. We show that Tmem120a gene knockout in fat leads to lipodystrophy in mice due to disrupting genome organisation in fat https://t.co/fjheYJcEsZ