Spagnoli Lab

Developmental and stem cell biology lab. Understanding the control of cell identity and plasticity and how to use it in regenerative medecine @KCLstemcells

[Spagnoli Lab @LabSpagnoli]

So excited to share our new paper today @Nature

Truly interdisciplinary study: #computational modelling, #lineagetracing and #scRNASeq uncovers sustained plasticity in hepato-pancreato-biliary development (1/2)
https://t.co/lqo1yVSp5S
@LabSpagnoli @KCLstemcells @kingsmedicine

[Biomedicina BCN @the_prbb]

📣 New PRBB-CRG conference

📋 Mapping progenitor niche dynamics for regulation of cell fate
🗣️ Francesca Spagnoli (@LabSpagnoli) - @KCLstemcells

📆 May 22 - ⏰ 12:00
hosted by: @1jorgeferrer - @CRGenomica

📍 #PRBB Maria Skłodowska-Curie room

[Spagnoli Lab @LabSpagnoli]

🎇Great fun writing this #review with
#AlejoTorresCano, highly talented postdoc in @LabSpagnoli

🤔reflecting on the emergence of #pancreatic #lineages in the #embryo through the lens of #plasticity
@wellcometrust @kingsmedicine @BreakthroughT1D @DUK_research

[Nature Reviews Gastroenterology & Hepatology @NatRevGastroHep]

New online! Understanding development and cellular plasticity in the pancreas in health and disease https://t.co/JMEGEU4ydV

[Pancreatic Cell News @PancreaticCell]

Drs. Alejo Torres-Cano (@LabSpagnoli) and Francesca Spagnoli explore how cellular plasticity and microenvironmental interactions drive #PancreaticDevelopment, regeneration, and disease, with implications for therapies for diabetes and pancreatic cancer.

Read the #review in @NatRevGastroHep: https://t.co/ZloeWmZt4f

[Giulia Biffi @BiffiGiulia]

🎉 Very happy to have had the opportunity to contribute to this latest @DiseasePrimers #Review on #PancreaticCancer together with a number of great colleagues! @ednacukierman @EileenMOReilly @SaurLab @BarbaraGrnwald ...

Hope it is a useful read! 😊💜

https://t.co/Q6dZPdHClD

[richard white @whitefishlab]

My department at Oxford is recruiting junior faculty to the Ludwig Institute for Cancer Research. A collaborative and stimulating department, with great access to the breadth of the Oxford environment. The positions come with core funding and cutting edge technologies. If interested, apply here: https://t.co/R5Lah3bZB3

[biorxiv_devbio @biorxiv_devbio]

Mesodermal-niche interactions direct specification and differentiation of pancreatic islet cells in human multilineage organoids https://t.co/UrgWK9JjXG #biorxiv_devbio

[King's Faculty of Life Sciences & Medicine @kingsmedicine]

New research from Professor Francesca Spagnoli reveals how different cell types develop, assemble, and communicate to build a functioning pancreas.🧬

https://t.co/vHlaLUNhmt

Image credit: Alejo Torres-Cano et al. Sci. Adv. 11,eadx5791(2025). DOI: 10.1126/sciadv.adx5791

[Spagnoli Lab @LabSpagnoli]

🚨 here it is the #DashBoard accompanying our new paper (see 🧵 below)
➡️ https://t.co/JFPPD4a04Z

😃 have fun exploring the dataset & #spatial #maps 🗺️

👏 👏 Kudo to Sami (#SiwanartaMa) MSc Bioinformatics for building the #DashBoard !!

[Spagnoli Lab @LabSpagnoli]

🚨 Check out our new paper is now online in its final version!!!
🎉 👏 Congratulations
Alejo Torres-Cano, who led the study
+ past & current team @LabSpagnoli
+ collaborators #VigilanteLab
@kingsmedicine

➡️ https://t.co/6JnJbCz5mJ...

[Spagnoli Lab @LabSpagnoli]

Spatially organized cellular communities shape functional tissue architecture in the pancreas | Science Advances https://t.co/BIU4xiJ8I2

[Spagnoli Lab @LabSpagnoli]

Congrats Alejo Torres-Cano postdoc in the @LabSpagnoli @KCLstemcells

[Pancreatic Cell News @PancreaticCell]

🕰️ Alejo Torres-Cano and team at @KingsCollegeLon combine single-cell and spatial transcriptomics to map pancreatic cell populations across space and time, from embryonic development to adult homeostasis in mice.

@ScienceAdvances | https://t.co/DiSnKNbiea

[Spagnoli Lab @LabSpagnoli]

🙏🙏 all our fundings @EUCouncil @wellcometrust
@NC3Rs #FundaciónAlfonsoMartínEscudero #postdoc support
@KCLBMBioscience
@BT1DUK #T1DGrandChallenge @DiabetesUK for next step of these discoveries

[Spagnoli Lab @LabSpagnoli]

🚨 Check out our new paper is now online in its final version!!!
🎉 👏 Congratulations
Alejo Torres-Cano, who led the study
+ past & current team @LabSpagnoli
+ collaborators #VigilanteLab
@kingsmedicine

➡️ https://t.co/6JnJbCz5mJ...

[Spagnoli Lab @LabSpagnoli]

We built ‘maps’ 💻showing that pancreatic progenitors and nearby supporting cells form niches &
used #stemcells 🧫to recreate pancreatic niches in the lab 🧪 & study how human beta cells develop

🙏 the Editor #ScienceAdvances & reviewers for great insights and comments

[Cambridge University @Cambridge_Uni]

https://t.co/KZMpWzTePc

[Arlotta Lab @ArlottaLab]

📢 📢Delighted to announce our latest pre-print co-led by our fantastic and talented postdocs @IreneFaravelli and @bolanosAnton 👩🏻‍🔬👩🏼‍🔬💪! Human cortical organoids record developmental time for 5 years in vitro. 🧫🧠⏳. A huge collaborative effort, big thanks to all co-authors! 🧵👇

[CU Diabetes Research Center @CUDiabetes]

Dr. Lori Sussel, Director of the CU Diabetes Research Center, recently delivered a keynote lecture titled “Unraveling the Regulation of Islet Cell Fates” at the European Islet Study Group Meeting in Malmö, Sweden. The event was hosted by the Lund University Diabetes Center.

[Irene Miguel-Aliaga @FlyGutLab]

Image analysis opportunity in our lab @TheCrick - deadline June 25
https://t.co/ZrVfEt0vMm

[Spagnoli Lab @LabSpagnoli]

@IldemAkerman @BreakthroughT1D @BT1DUK Thank You for the donation!!! 😀

[Spagnoli Lab @LabSpagnoli]

My Lab. and I are doing it again!!
🚶‍♀️🚶🏃‍♀️10K One Walk London for T1D research !!!
Please help us raise funds for Breakthrough T1D!
Your support will help change the lives of everyone affected with T1D - Thanks so much!
https://t.co/911w88tSVr
@BreakthroughT1D
@BT1DUK