Adaptive immune regulation of innate immunity ✨ the paradigm has been innate immune regulation of adaptive immunity but the relationship is bidirectional. So much to discover and learn here.
https://t.co/MiNJLScZmD
My lab at @Stanford is looking to hire postdocs for multiple projects on cancer biology and therapeutics. Our recent work has uncovered some truly remarkable mechanisms for cytotoxic small molecules and we're looking to build on this research. If interested, see below:
Transient host-cell glycoengineering to reduce N-glycan trimming strengthens IgG-FcγRIIIa bond resilience under vascular flow forces and potentiates therapeutic antibody efficacy in lymphoma and melanoma models @ImmunityCP@LabTaia@Stanford@UWBioE
https://t.co/g20X3zMq6Q
Congratulations to Wang’s lab @LabTaia, and Bowie @Bowie0625 on this elegant and impactful work, showing that antibody efficacy is not just about affinity, but also the durability of IgG-FcyR interactions under physiological forces.
https://t.co/gvNendunVL
Out today in @ImmunityCP! We define how sialylation of IgG Fc domains regulates NF-κB-driven responses in the lungs.
https://t.co/I1aAOi309B
@StanfordMed @HHMINEWS @niaidcivics
@soundgmh@ImmunityCP@StanfordMed @HHMINEWS @niaidcivics Afucosylated and asialylated Fc glycoforms predict more severe COVID-19 and the reduced sialylation in severe COVID-19 likely has a functional role (as well as the increase in afucosylation). Likely a broad role in respiratory infections but this needs to be studied.
@GordanLauc The hypothesis is strong, that “glycans are essential for nearly all aspects of immunity”, that’s why we do the work that we do. But there is so much to discover here and we are only at the tip of the iceberg.
Sialylated IgG protects against lung inflammation and severe influenza disease... Actually glycans are essential for nearly all aspects of immunity, but one has to look to see...
https://t.co/d2K4outRIO
RFK Jr. has no medical or scientific credentials and wants to gut the National Institutes of Health. And Marjorie Taylor Greene today cheered him on in our committee. This is outrageous and shameful.
Thank you to @TheLancetInfDis for featuring my research and early career in infectious diseases and public health. Check it out! https://t.co/fRBniNjHIy
Sialylated IgG induces expression of REST in alveolar macrophages via CD209, where REST dampens the responsiveness of macrophages to multiple NFκB stimuli and controls the inflammatory lung response to influenza viruses @ImmunityCP@LabTaia
https://t.co/UoJob5nh4l
#CARTcells for #DIPG#DMG clinical trial (1st arm) results are out today. Full Tweetorial coming, but first want to share the story of a patient whose #DIPG has disappeared for over 3 years. It is a milestone and moment of hope on a journey filled with so much grief.
“There’s a lot of loss that led to this research,” Drew’s dad said. “I hope those families know that this success is because of them.”
https://t.co/rNnHkL6pQR