Saghatelyan Lab

Neuroscientists interested in adult neural stem cells, postnatal neurogenesis and olfaction

[Saghatelyan Lab @Lab_Saghatelyan]

Happy to share our article in @NeuroCellPress

We show how cilia beating of ependymal cells lining the walls of brain ventricles regulate neural stem cells activation/quiescence.
This work was made possible by an amazing work of trainees in the lab and wonderful collaborators 1/7

[Neuron @NeuroCellPress]

Online now: Cilia beating of ependymal cells regulates adult neural stem cell quiescence via mechanical forces mediated by PKD1/2-TRPM3 https://t.co/jKtnnAdT0r

[Saghatelyan Lab @Lab_Saghatelyan]

@SChenlab Thanks Simon!

[Saghatelyan Lab @Lab_Saghatelyan]

Happy to share our article in @NeuroCellPress

We show how cilia beating of ependymal cells lining the walls of brain ventricles regulate neural stem cells activation/quiescence.
This work was made possible by an amazing work of trainees in the lab and wonderful collaborators 1/7

[Neuron @NeuroCellPress]

Online now: Cilia beating of ependymal cells regulates adult neural stem cell quiescence via mechanical forces mediated by PKD1/2-TRPM3 https://t.co/jKtnnAdT0r

[Saghatelyan Lab @Lab_Saghatelyan]

@LisaJ456 @NeuroCellPress Thanks Lisa!

[Sheena Josselyn @sjo09]

New paper from the lab. Using longitudinal ca imaging, activity-dependent tagging and optogenetics, we show that newly allocated fear engram neurons in amygdala undergo a brief period of coordinated “offline reverberation” immediately after learning.

https://t.co/ELcRXieer2

[Saghatelyan Lab @Lab_Saghatelyan]

@neur1s @NeuroCellPress Thank you Sofiya!

[Saghatelyan Lab @Lab_Saghatelyan]

@karunsinghneuro @NeuroCellPress Thanks Karun!

[Saghatelyan Lab @Lab_Saghatelyan]

Many questions remain unanswered for EC-NSCs mechanical interactome and whether similar mechanisms are at play in other somatic stem cells that are also surrounded by ciliated epithelial cells.

Huge thanks to the reviewers for their very insightful comments and @NeuroCellPress

[Saghatelyan Lab @Lab_Saghatelyan]

This work reveals an intricate interplay between ECs and NSCs through mechanical forces and highlights some of factors/mechanisms that may lead to generation of these mechanical forces. 6/7

[Saghatelyan Lab @Lab_Saghatelyan]

@Masha_P_K @MakashovaOlena @LaporteCeleste @Chris_QChen @osmoland @AKhoutorsky @mcgillu @McGillMed Huge congrats Masha!

[Saghatelyan Lab @Lab_Saghatelyan]

@vbprovencher Bravo Vincent!

[Saghatelyan Lab @Lab_Saghatelyan]

@Franklandlab Huge congrats Paul!

[Karun K Singh @karunsinghneuro]

Come to our 7th Satellite meeting (Stem Cells, Brain Development and Regeneration) in Toronto, May 21st 2025! Great line up of speakers including trainee talks. Great place to network and showcase your work! Spots still available.

[Saghatelyan Lab @Lab_Saghatelyan]

@AKhoutorsky @Weihua1990 @AmirMinerbi @GonzalezEmBio @King_Lab_McGill Congrats Arkady!

[Saghatelyan Lab @Lab_Saghatelyan]

@NeuroNaud @JCBeique @grossmancooper @efharkin_ Huge congrats Richard, @JCBeique and the team!

[Saghatelyan Lab @Lab_Saghatelyan]

@antoinedechevig Thanks a lot Antoine! Hope all is well!

[Saghatelyan Lab @Lab_Saghatelyan]

Thrilled to share our work on how neural stem cells (NSCs) interact with distinct cell types in their niche. We use Ca2+ imaging in NSC processes and post-hoc iterative immunolabeling for multiple cell types to link NSCs functional activity to niche cell types inducing it. 1/8

[Saghatelyan Lab @Lab_Saghatelyan]

Don’t miss our satellite meeting on Stem Cells, Brain Development and Regeneration at @CAN_ACN .
Stellar line-up of speakers, several slots for trainees talks!
The program and registrations at Stem Cells, Brain Development and Regeneration – Canadian Association for Neuroscience