Landon Simcoe

Clemson | Nashville

[Anish Moonka @anishmoonka]

Your dog could soon get a daily pill that slows aging. 1,300 dogs are already testing it across 70 vet clinics, and it just passed its second FDA safety review in January.

The drug is LOY-002. A San Francisco startup called Loyal makes it. Celine Halioua started the company in 2019 when she was 24. They have raised $250 million so far, including $100 million in February from Baillie Gifford, the same firm that bet early on Tesla and Amazon.

The simplest way to explain what it does: if you put a dog on a strict diet where it eats way less food, that dog tends to live about two years longer. Cancer and arthritis both show up later. The body just ages more slowly. LOY-002 gives the dog those exact benefits without actually eating less. The dog keeps its appetite and its weight; it just ages more slowly.

The trial is called STAY. Half the dogs get a beef-flavored pill every day, and the other half get a fake version that looks and tastes the same. The FDA reviewed safety data from over 400 dogs. Zero serious side effects, even at five times the normal dose. Loyal has now cleared two of three hurdles for conditional approval, which basically means they could start selling the drug while the full trial keeps going. The last piece, manufacturing, goes to the FDA in 2027.

One thing the tweet gets a bit wrong: the pill is for senior dogs aged 10 and older, at least 14 pounds. And Loyal is being careful about the "years" claim. Right now, they are saying at least one extra year of healthy life. They want to prove more, but the trial needs to finish first.

If LOY-002 gets approved, it would be the first drug the FDA has ever cleared to slow aging in any species, human or animal. Loyal also has two more drugs coming for big breeds like Great Danes and Rottweilers. Those dogs die younger partly because of a hormone called IGF-1, which makes them grow fast but also wears their bodies out quicker. And a separate project backed by a $7 million grant from the NIH (the agency that funds medical research) is testing a human organ transplant drug called rapamycin in 580 dogs to see if it slows aging, too.

The global pet care market hit $261 billion last year. A once-a-day pill that gives your dog even one extra healthy year could easily become one of the best-selling veterinary drugs on the planet.

[Unnecessary Roughness @UnnecRoughness]

8 minutes of Dabo Swinney flaming Ole Miss for tampering with Clemson’s Luke Ferrelli

“Pete Golding just does what he does."

Dabo shares an entire timeline of the events

Wow

[Emmanuel Acho @EmmanuelAcho]

Game on the line, 4th & 11, and this is what Kevin Patullo and Nick Sirianni come up with?

Sickening. #FlyEaglesFly | @speakeasytlkshw

[Philly Sports Sufferer @mccrystal_alex]

I never have to watch Kevin Patullo hoops again

[Jason Ashworth @AllAshworth]

The Eagles will trade Brown. The’ll lose Goedert and Dean (most likely) to FA. They wasted a REALLY good team and a unique opportunity to be “special” on Kevin FUCKING Patullo.

Absolute malpractice that was evident from the jump. And they did nothing.

They deserve this L.

[Pardon My Take @PardonMyTake]

Kevin Patullo tomorrow

[Connor Griffin @RealCGriff]

The defending Super Bowl champs, with maybe the most loaded offensive roster in the league, gave playcalling duties to a man who had never called plays before, and they just waited an entire season for him to try and figure it out.

I’ll never get over it. What a waste of a year.

[Josh Reynolds @JoshReynolds24]

I never want to hear the name Kevin Patullo ever again. What an absolute waste of a season with the most loaded offense in the NFL. Absolute joke. Never, ever again.

An embarrassment beyond words

[Philly Sports Sufferer @mccrystal_alex]

Me pretending to be a make a wish kid to meet Kevin Patullo

[The Birds Blitz @TheBirdsBlitz]

THANK YOU, RICHARD SHERMAN

[Mina Kimes @minakimes]

Eagles sports radio is gonna make the red wedding look like a romantic comedy

[Kevin Negandhi @KevinNegandhi]

No excuse whatsoever for the Eagles offense to not score a point in the final 41:30 vs one of the worst defenses in the league.

None.

[Lord Brunson tweets @lord_brunson]

Patullo fucking stinks man

[ruby 🇲🇽 @rubythevalley]

fangio needs to slap the shit out of patullo

[Laz🇱🇷🦅 @Lazerus]

Kevin Patullo trying to confuse the Packers defense

[Jimmy Kempski @JimmyKempski]

We're trending toward another cryptic tweet.

[Barstool Gambling @stoolgambling]

Clemson was up 45-38 and got called for PASS INTERFERENCE on 4th down…

Duke now leads 46-45 with under a minute left

[BirdGang🦅 @GordonsWord]

Kelee Ringo might be the worst CB in the league

[Bleeding Green Nation @BleedingGreen]

Getting carved up by a pair of rookies without their two best WRs. Disgraceful