Ewa Langner

Instructor at Suleiman Lab @hansul @UTSWNephrology
Studying centrosomes and cilia role in kidney development and disease.

[Cytoskeleton Journal @CytoskelJournal]

It's #fluorescencefriday and we've got a wonderful image for you. The inside front cover of the #cilia and #flagella #special issue. Enjoy! https://t.co/mK3pi5ONnB @LangnerEP

[Ewa Langner @LangnerEP]

It's #microscopymonday!🔬
Super happy that special issue on @CytoskelJournal is out now with the beautiful cover🤩🥳@MahjoubLab

[Moe Mahjoub 🇨🇦🍁 @MahjoubLab]

Happy #FluorescenceFriday everyone 🔬🌈

Super stoked that our image made the cover of the special issue on #Cilia and #Flagella at @CytoskelJournal 😍

Hey @LangnerEP congrats on your back-to-back journal covers!

Link to special issue: https://t.co/4YzMjxY2zZ

[Cytoskeleton Journal @CytoskelJournal]

For #FluorescenceFriday we have another wonderful #picture of the month in #CYTOSKELETON @CytoskelJournal Enjoy! @LangnerEP @MahjoubLab #microscopy #kidney

[Ewa Langner @LangnerEP]

Happy to share one of the pictures of the month @CytoskelJournal😍🔬🩵
Happy #FluorescentFriday to y'all!

[Moe Mahjoub 🇨🇦🍁 @MahjoubLab]

Happy #FluorescenceFriday 🔬 - part 1:

Congrats to @LangnerEP for her POTM!

[Ewa Langner @LangnerEP]

@MahjoubLab @UTSWNephrology Thanks Moe! My microscopy adventure started in your lab 🔬🩵

[Ewa Langner @LangnerEP]

Check out these amazing winning images of Nikon 2024 Photomicrography Competition! #NikonSmallWorld Congratulations to all the winners of this year's edition!👏👏🔬https://t.co/0A2fMGU2TE

[Moe Mahjoub 🇨🇦🍁 @MahjoubLab]

Happy #FluorescenceFriday all! 🔬🌈

And big congrats to my former postdoc @LangnerEP (now @UTSWNephrology) for having her beautiful image of an embryonic #kidney selected as an "Image of Distinction" in the 50th anniversary #NikonSmallWorld competition!

[Ewa Langner @LangnerEP]

Extremely excited about the future at @UTSWNephrology and Suleiman Lab @hansul.

[Ewa Langner @LangnerEP]

My 5-year long, amazing adventure at WashU @MahjoubLab come to an end. Extremely grateful for how much I have learned. The biggest thank you to my great mentor, Dr Moe Mahjoub, but also to all faculty of @WUNephrology and Cilia and Centrosome Group at WashU.

[Moe Mahjoub 🇨🇦🍁 @MahjoubLab]

It’s a tough day. Sad to say goodbye to my amazing postdoc @LangnerEP, but super happy for her move to @UTSWNephrology with @hansul to start their group, and the next phase of her science journey. I’m super proud of you and everything you’ve achieved!

I’m not crying…

[WashU Nephrology @WashUNephrology]

Congratulations to the @MahjoubLab for their recent publications detailing the critical role of #centrosomes in #kidney development and function, one landing cover of @JCI_insight! Great work by first-authors @ChengTao_PKD, @LangnerEP and all co-authors.
https://t.co/LD1zRt8EO7

[Ewa Langner @LangnerEP]

Perfect day #FluorescenceFriday to celebrate my image of🐭kidney getting onto the cover @JCI_insight🫣😍💜🙌
Plus, additional opportunity to one more time celebrate great paper from the lab @MahjoubLab @ChengTao_PKD 👏🍾

[JCI insight @JCI_insight]

#Cover: Inhibiting centrosome clustering reduces cystogenesis & improves #kidney function in autosomal dominant polycystic kidney disease: https://t.co/a77dnzqE1B

Image: immunofluorescence staining of developing embryonic mouse kidney; credit: Ewa Langner.
@MahjoubLab @WUSTLmed

[Moe Mahjoub 🇨🇦🍁 @MahjoubLab]

Our latest study is now published @JCI_insight and OMG WE GOT THE COVER! 😱😱😱

Congrats to my amazing postdoc @ChengTao_PKD for this herculean effort (~5 yrs), and to @LangnerEP for the beautiful image that made the cover 😍

Lemme tell you about our study real quick👇

[Moe Mahjoub 🇨🇦🍁 @MahjoubLab]

Hey #nephrology aficionados:

Are you interested in achieving nanoscale (<50nm) level resolution of organelles, cytoskeletal components, and other subcellular structures?

Would you like to avoid doing electron microscopy?

Then let me tell you how 👇

https://t.co/WLN78lSyeV

[Ethos Biosciences - an Ott Scientific Company @EthosBioscience]

Happy #FluorescenceFriday & #GroundhogDay!

[Samuel Hume @DrSamuelBHume]

Women are 4-times more likely to have autoimmune diseases than men. Why is this?

From Dou et al. in Cell, today

In females, the second X chromosome is silenced by a long non-coding RNA, called Xist (pronounced 'exist') - males don't express Xist

Xist, together with almost 100 unique proteins, wraps itself around the second X chromosome, silencing it. It's thought that Xist-protein complexes are highly immunogenic, and may represent targets for autoantibodies

Dou et al. devised a system to induce expression of Xist in male mice. They found that Xist expression led to the production of autoantibodies, similar to levels found in female mice (RIBO P0/P2 are lupus autoantibodies, CENPA/B are scleroderma autoantibodies):
In a mouse model, these autoantibodies in Xist-expressing males were sufficient to cause significant lupus pathology (including in the kidney and the lung):
In humans, autoantibodies against the Xist ribonucleoprotein complex were enriched in female patients with lupus, scleroderma, and dermatomyositis

Therefore, Xist may solve the puzzle of female-biased autoimmunity

https://t.co/95sqEMGqJ8

[EMBO Reports @emboreports]

Cep120 is essential for kidney stromal progenitor cell growth and differentiation.

-> https://t.co/ZFrDyrIiSy

[Moe Mahjoub 🇨🇦🍁 @MahjoubLab]

Live views of @ChengTao_PKD and Ewa Langner celebrating their third manuscript acceptance in a month 🍾

Happy long weekend, all!

[Biomedical Picture of the Day BPoD @BPoD_s]

Protein #CEP120, essential for #centrosome function, underlies normal #kidney function & injury repair. Image & research by Ewa Langner et al @MahjoubLab @WUNephrology @WUSTLmed in @emboreports. On https://t.co/CAMO1NjgaO where you'll find the article links & 4000+ BPoD archive