Can early CAR T-cell redosing improve the therapeutic index of CAR T-cell therapy?
Our study, now published in @Haematologica, suggests that an early (day +14) second CD19 CAR T-cell infusion may increase CAR T-cell exposure, prolong persistence, and improve response durability.
Real-world patient-reported symptomatic adverse events and concordance with physician assessments after CAR T-cell therapy in patients with aggressive B-cell lymphomas: a prospective study - The Lancet Haematology https://t.co/rxq2oO0dQw
Frente a quienes actúan con irresponsabilidad, es necesario plantar cara y defender con rigor el sistema de trasplantes que salva vidas cada día.
Gracias a @elconfidencial por darme voz. Pido difusión para que la verdad llegue más lejos que el ruido.
https://t.co/CTViWTSfTb
What a great meeting it has been #cart26 !
Many congratulations to the wonderful scientific committee led by @AnnalisaRugger1 and @MariaThemeli1 for a superb programme and everyone involved for the delivery of the meeting!
Fantastic keynotes but more importantly a fantastic set of abstracts of novel research that shows that CAR-T research is ever growing
From haematological cancers to autoimmune diseases and solid tumours, CAR T cell therapies and their close cousins (NKs, γδ) have the potential to transform medicine. Future will be bright and exciting! See you all soon
🚨New in Lancet Haematology:
CART19-BE-02 reports the multicentre phase 2 trial of varnimcabtagene autoleucel (var-cel), a hospital-based, point-of-care CD19 CAR T for adults with R/R B-cell precursor ALL.
https://t.co/OD0Q3M98Ud
🔓Free access link:
https://t.co/p3O7qOLrlm
Dr @CaitieGribbinMD presented incredibly data on the role of follicular dendritic cells and the temporal relationship with FL progression… with actionable targets! Incredible and provocative work, we’re excited to have her join our faculty! @WCMHemOncFellow@WCMLymphoma#ASH24
Testicular large B‐cell lymphoma is genetically similar to PCNSL and distinct from nodal DLBCL - Rivas‐Delgado - 2024 - HemaSphere - Wiley Online Library https://t.co/hNwcQRhVON
Clinical Practice Recommendations for Hematopoietic Cell Transplantation and Cellular Therapies in Follicular Lymphoma: A Collaborative Effort on behalf of The American Society of Transplantation and Cellular Therapy and the EBMT https://t.co/BiZigV7BUW
Today, at TLH, we summarise a decade of hard work. We wish to thank all colleagues, patients and relatives, who helped us during this amazing journey.
https://t.co/CIzVqbLH3m
FDA Investigating Serious Risk of T-cell Malignancy Following BCMA-Directed or CD19-Directed Autologous Chimeric Antigen Receptor (CAR) T cell Immunotherapies https://t.co/Zebpq3kQKx
Although CRS/ICANS still seem to get most of the attention, it's infections that remain one of the main causes of morbidity and mortality after CAR T cell therapy.
Here some insights on this matter by the our dearest @NicoleGarciaP 💪💫 @hospitalclinic
https://t.co/R2snU4Vk63