1 in 5 neurosarcoidosis exhibit comorbid autoimmune disease, family history of autoimmunity, or nonspecific autoantibody seropositivity. These overlapping features represent potential sources of diagnostic ambiguity and may impact treatment strategies.
Check the paper below 👇
Across MS, metabolic disease, and now CAD, one theme repeats: disease-linked microbes often trace back to Lachnospiraceae. Many diseases, many signatures… but one familiar storyline. Also Akkermansia muciniphila was linked with both disease & health
https://t.co/xjss4jNCE2
A recent study from @Ashu_Mangalam's research lab has produced the most comprehensive genetic and metabolic analysis to date of the oral microbiome associated with #multiplesclerosis. #PathTwitter
Read more about his study on our website: https://t.co/evSoLuz8pP
Neoehrlichiosis, an emerging, underdiagnosed tick-borne infection.
B-cell–depleting therapy increases risk and severity. #MS patients with fever, high CRP, or anemia may need further attention prior treatment initiation.
#InfectiousDisease#MS#Neoehrlichiosis
Paper below 👇
CAR-T therapy has transformed hematologic cancers, but ICANS remains a major barrier. Diverse neurotoxicities, lack of biomarkers, and unclear mechanisms highlight an urgent unmet need. #CART#Neurotoxicity#crackingICANS
Check out the paper below 👇
https://t.co/j8BSF9mB2A
Insight into stroke recovery!
miR-126 worsens brain injury by suppressing LRP6 in the Wnt/β-catenin pathway. Blocking it restores signaling, reduces cell death, and improves outcomes - a promising new stroke therapy target.
#StrokeResearch ##miR126#WntPathway
Check the paper 👇
It was a great pleasure to present at the #ISNI2025 (Japan) on Dietary Modulation of Gut Microbiota and Immune-Metabolic Profiles in Multiple Sclerosis. There were many great discussions and presentations!
Honored to be part of the Symposium on #Microbiome & Neuroimmunology at #ISNI2025 (Japan) with Laura Piccio, Sergio Baranzini, Daiki Takewaki & Alessandro Maglione.
We highlighted how diet, microbes & metabolites shape MS, from composition to function.
#weareneuroimmunology
CSF cell analysis is key to understanding neurological diseases but has been limited by cell fragility. Millet Wallisky et al. introduce a rapid, one-step method for efficient CSF immune profiling
Check out the paper below 👇
https://t.co/loCOZF1gVX
Microglia stuffed with fat struggle. Knocking out a lipid-droplet regulator in them boosted their appetite for Aβ and tempered plaque load. @NTUsg https://t.co/ZaA5BLmn74
1/ I am thrilled to share our latest paper: A single-cell compendium of human cerebrospinal fluid identifies disease-associated immune cell populations, @jclinicalinvest! Thanks to @MS_ResearchDoc, @BrianEdelson2, @maxim_artyomov, and co-author Roma for this collaborative effort!
IL-2, IL-33 & Retinoic Acid activation increase ILC1 levels in RRMS, compared to lower ILC2 in inactivated conditions.
While MS disease progression index (PI) in RRMS is associated with ratios of IL-10+ ILC1/ILC1, c-Kit+ ILC2/c-Kit-ILC2, and CCR6* ILC2/ILC2.
Check this out👇
Delighted to our Special Issue #infections and #neurodegenerative diseases.
Editors @FrancescaAloisi & @giovanidechiara
Check out the link below for more details:
https://t.co/r5d2eLtH3U
Case report series of Down Syndrome Regression Disorder (DRSD) #DRSD known to be prone for autoimmunity demonstrate DRSD neurological symptoms improvement in response to #tofacitinib
@joaquinespinosalab @ColoradoUni
Check the manuscript below ⬇️
https://t.co/Conx3edpB3