Piccio Lab

PI: Laura Piccio | If you're interested in our study, please contact [email protected] | [email protected]

[Journal of Neuroimmunology (JNI) @JNI_Journal]

The Journal of Neuroimmunology welcomes submissions from early career researchers!!

[Journal of Neuroimmunology (JNI) @JNI_Journal]

1 in 5 neurosarcoidosis exhibit comorbid autoimmune disease, family history of autoimmunity, or nonspecific autoantibody seropositivity. These overlapping features represent potential sources of diagnostic ambiguity and may impact treatment strategies.

Check the paper below 👇

[Ashutosh Mangalam @Ashu_Mangalam]

Across MS, metabolic disease, and now CAD, one theme repeats: disease-linked microbes often trace back to Lachnospiraceae. Many diseases, many signatures… but one familiar storyline. Also Akkermansia muciniphila was linked with both disease & health

https://t.co/xjss4jNCE2

[University of Iowa Pathology @UIPathology]

A recent study from @Ashu_Mangalam's research lab has produced the most comprehensive genetic and metabolic analysis to date of the oral microbiome associated with #multiplesclerosis. #PathTwitter

Read more about his study on our website: https://t.co/evSoLuz8pP

[Journal of Neuroimmunology (JNI) @JNI_Journal]

Neoehrlichiosis, an emerging, underdiagnosed tick-borne infection.
B-cell–depleting therapy increases risk and severity. #MS patients with fever, high CRP, or anemia may need further attention prior treatment initiation.
#InfectiousDisease #MS #Neoehrlichiosis

Paper below 👇

[Journal of Neuroimmunology (JNI) @JNI_Journal]

CAR-T therapy has transformed hematologic cancers, but ICANS remains a major barrier. Diverse neurotoxicities, lack of biomarkers, and unclear mechanisms highlight an urgent unmet need. #CART #Neurotoxicity #crackingICANS

Check out the paper below 👇

https://t.co/j8BSF9mB2A

[Journal of Neuroimmunology (JNI) @JNI_Journal]

Insight into stroke recovery!
miR-126 worsens brain injury by suppressing LRP6 in the Wnt/β-catenin pathway. Blocking it restores signaling, reduces cell death, and improves outcomes - a promising new stroke therapy target.
#StrokeResearch ##miR126 #WntPathway

Check the paper 👇

[Journal of Neuroimmunology (JNI) @JNI_Journal]

It was an honor to sponsor the ISNI Young Session, Symposium 22 at #ISNI2025 in Chiba! 🌏

Congrats to our winner, @rosadelegadojimenez, and all speakers!

Special thanks to @hwiendl for making this session a success! 🙏

#Neuroimmunology #ISNI2025 #NextGenerationScientists

[Piccio Lab @LauraPiccio]

It was a great pleasure to present at the #ISNI2025 (Japan) on Dietary Modulation of Gut Microbiota and Immune-Metabolic Profiles in Multiple Sclerosis. There were many great discussions and presentations!

[Ashutosh Mangalam @Ashu_Mangalam]

Honored to be part of the Symposium on #Microbiome & Neuroimmunology at #ISNI2025 (Japan) with Laura Piccio, Sergio Baranzini, Daiki Takewaki & Alessandro Maglione.

We highlighted how diet, microbes & metabolites shape MS, from composition to function.

#weareneuroimmunology

[Journal of Neuroimmunology (JNI) @JNI_Journal]

CSF cell analysis is key to understanding neurological diseases but has been limited by cell fragility. Millet Wallisky et al. introduce a rapid, one-step method for efficient CSF immune profiling

Check out the paper below 👇

https://t.co/loCOZF1gVX

[Alzforum @alzforum]

Microglia stuffed with fat struggle. Knocking out a lipid-droplet regulator in them boosted their appetite for Aβ and tempered plaque load. @NTUsg https://t.co/ZaA5BLmn74

[WashU Medicine Neurology @WashUNeurology]

An article in @jclinicalinvest — Gregory Wu, MD, PhD (@MS_ResearchDoc), & peers — describes huge strides in understanding CSF immune cells using single-cell RNA sequencing, factors driving MS, Alzheimer, Parkinson diseases.
@maxim_artyomov @BrianEdelson2
https://t.co/hdzqyLp8T0

[Claudia Cantoni @Clodida]

1/ I am thrilled to share our latest paper: A single-cell compendium of human cerebrospinal fluid identifies disease-associated immune cell populations, @jclinicalinvest! Thanks to @MS_ResearchDoc, @BrianEdelson2, @maxim_artyomov, and co-author Roma for this collaborative effort!

[Roberta Magliozzi @rmagliozzi73]

snRNA-seq stratifies multiple sclerosis patients into distinct white matter glial responses: Neuron https://t.co/u7Z3ukwgix

[Journal of Neuroimmunology (JNI) @JNI_Journal]

Check out this nice overview summary of LPS induced neuroinflammation models.

Link below ⬇️

https://t.co/fgO9TDYPNp

[Journal of Neuroimmunology (JNI) @JNI_Journal]

IL-2, IL-33 & Retinoic Acid activation increase ILC1 levels in RRMS, compared to lower ILC2 in inactivated conditions.

While MS disease progression index (PI) in RRMS is associated with ratios of IL-10+ ILC1/ILC1, c-Kit+ ILC2/c-Kit-ILC2, and CCR6* ILC2/ILC2.

Check this out👇

[Pablo Naval-Baudin @pnavalbaudin]

🚨🧠 Big news for #MultipleSclerosis diagnosis! 🚨

At #ECTRIMS2024, the 2024 McDonald Criteria were just released by @XMontalban and this changes everything for #Neuroradiology and #MSDiagnosis.

Here’s what you need to know 🧵👇

[Journal of Neuroimmunology (JNI) @JNI_Journal]

Check out our @JNI_Journal special issue in Infectious and Neurodegenerative diseases with @FrancescaAloisi and @GiovannaDechiara

[Journal of Neuroimmunology (JNI) @JNI_Journal]

Delighted to our Special Issue #infections and #neurodegenerative diseases.

Editors @FrancescaAloisi & @giovanidechiara

Check out the link below for more details:

https://t.co/r5d2eLtH3U

[Journal of Neuroimmunology (JNI) @JNI_Journal]

Case report series of Down Syndrome Regression Disorder (DRSD) #DRSD known to be prone for autoimmunity demonstrate DRSD neurological symptoms improvement in response to #tofacitinib

@joaquinespinosalab @ColoradoUni
Check the manuscript below ⬇️

https://t.co/Conx3edpB3