Fabien Le Grand

Researcher in muscle cell biology. Addicted to signaling pathways (Wnt, Tgfb, Bmp). PI at Institut NeuroMyoGène.

[Fabien Le Grand @LeGrandLab1]

With @GilbertLab , we designed a pipeline to study communications toward muscle stem cells during tissue regeneration. How do MuSCs re-quiesce? Check the work by our star students @GarciaPaulineJ & @Erik_Jacques_ in our new preprint.
https://t.co/floBl7nDDj

[Fabien Le Grand @LeGrandLab1]

@nathangburns You could not find a better place to read our paper 😃

[Fabien Le Grand @LeGrandLab1]

I am delighted to share our newest paper. @GarciaPaulineJ found that Setdb1 is absolutely required for muscle tissue regeneration. This by keeping ancient viral elements silenced in muscle stem cells. @EJPRareDiseases @iNeuroMyoGene @AfmPresse

[Developmental Cell @Dev_Cell]

Online now: Setdb1 protects genome integrity in murine muscle stem cells to allow for regenerative myogenesis and inflammation https://t.co/3hKyqQR4Tc

[Fabien Le Grand @LeGrandLab1]

@vaiter Je suis dans la même situation, très anxiogène vu le travail investi avec les partenaires PRC. Une réponse @AgenceRecherche ?

[Samuel Vaiter @vaiter]

J'ai un dépôt ANR de Schrodinger🐈.

J'ai un email qui accuse réception de ma soumission, et un autre email qui me dit que ma soumission ne sera pas évalué car pas reçu.

À moins que cela soit une soumission normande🤨?

[Fabien Le Grand @LeGrandLab1]

@AgenceRecherche j'ai recu, mercredi, mail de confirmation de votre part de l'enregistrement de notre pre-proposition PRC. Hier je reçoit un mail prétendant une "absence de confirmation", que notre projet ne sera pas considéré. Veuillez expliquer ces contradictions, je vous prie.

[Fabien Le Grand @LeGrandLab1]

@DumontN_Lab @NatureComms Bravo Nicolas et Collègues ! 🔥

[Fabien Le Grand @LeGrandLab1]

@mick17000 A great suggestion! Let me run it through @EpigeneticsYOW , and see what the chairman thinks of it 😁

[Fabien Le Grand @LeGrandLab1]

Delighted to share our latest work on BioRxiv. During her PhD, @GarciaPaulineJ relentlessly studied the impact of removing the H3K9 methyltransferase Setdb1 in muscle stem cells. Strikingly she found Setdb1 is absolutely required for regeneration 1/n
https://t.co/V6m2gVwE7l

[Fabien Le Grand @LeGrandLab1]

This work will be presented live, next thursday at the GRC Myogenesis meeting. If you are attending, you should read the preprint so you may (1) Ask well thought-after questions or (2) Skip my talk and go swimming/running instead 😉

[Fabien Le Grand @LeGrandLab1]

Read our preprint, and send us your feedback 😃. We deeply thank to the funding by @EJPRareDiseases @Telethon_France and our collaborator @t_cheung .

[InstitutNeuroMyoGène @iNeuroMyoGene]

Un poste de gestionnaire financier est à pourvoir au sein de l'INMG.

Découvrez l'annonce ci-dessous 👇

[Gilbert Lab @GilbertLab]

You asked for it #myotwitter and @Erik_Jacques_ delivered! A new 3D assay to study regulators of muscle stem cell quiescence and niche repopulation principles 'in a dish'. Our easiest method YET! What questions will you ask?

[Fabien Le Grand @LeGrandLab1]

Check out Nicolas Rose study, out in Biomaterials. He navigated between three labs/co-supervisors during his PhD, and yet successfully created very tiny 3D myotubes between pillars. This is a new tool to measure the force generated by a single human muscle cell in health/disease.

[Fabien Le Grand @LeGrandLab1]

@Mic_Hicks @apkann I wash and stain fibers in wells of a 48-well plate. I let them sediment, no spinning. Also, at the beginning, I was loosing quite a lot of fibers during plating on the microscope slide (stuck to the glass pipet). I found that doing the last wash with PBS+5%serum really helps.

[Fabien Le Grand @LeGrandLab1]

@DumontN_Lab @BentzingerLab @vahabsoleimani @chang_natasha Invite me over next time! I am not so far away 😁

[Fabien Le Grand @LeGrandLab1]

@AntoineZalc So, did you get your head checked? By a jumbo jet? 😁

[Fabien Le Grand @LeGrandLab1]

@jgryall I am having a great time, indeed.