Lea Lab

Structural biology lab at NCI-Frederick. Formerly University of Oxford. Studying protein structures at the host-pathogen interface. All views are our own.

[Lea Lab @LeaLabTweets]

Thank you to @robinson_julia of Chemistry World (Royal Society of Chemistry) for a lovely write up of our work. Read the article here: https://t.co/flZMNkXUuf. And for the original paper: https://t.co/JetRX6KtWf

[Chemistry World @ChemistryWorld]

Using cryo-electron microscopy two different groups have revealed new insights into how flagellum power bacteria to get where they're going. @robinson_julia reports: https://t.co/AIoToDQvcW

[Lea Lab @LeaLabTweets]

@christo71213435 @STCmicrobeblog Thank you for the kind words. We will look forward to the blog.

[Lea Lab @LeaLabTweets]

Reducing the complexity of a fascinating molecular motor. Read our Behind the Paper blog, where we detail our journey to deciphering the structural basis for how bacterial flagella shift into reverse gear: https://t.co/ki0UnetrIw

[Dunn_School (now @DunnSchool.bsky.social) @Dunn_School]

New meningitis vaccine developed by the @TangLabOxford!

The new chimeric protein-based #vaccine to tackle #MenB is the result of a strategic collaboration between @UniofOxford & @SerumInstIndia

Find out more: https://t.co/ZeXM9G9dza

[Nature Microbiology @NatureMicrobiol]

Also hot off the press! Our latest article on the structural analysis of protein transport by the T9SS is out now 👇https://t.co/yQ8dnYMCGY

[Kylie Walters (she/her) @kyliejwalters]

Thrilled to share that we teamed up across @theNCI and @nih_nhlbi to discover #degraders against #hRpn13 that trigger #apoptosis in #cancer cells in a study led by @xiuxiu_lu with structural data from @Monikachandrav2. 🎉

https://t.co/Yz6a3Ah2uh

[Susan Lea @S_M_Lea]

Published today @SJohnsonDPhil and @justindeme85 story finally revealing the molecular basis for transmission of uni-directional ion flow into bi-directional rotation of the bacterial flagellum https://t.co/x0Uxn8ZhWA

[Owain James Bryant @OJ_Bryant]

Check out our latest paper where we identify a new C-terminal export signal in flagellar Type III secretion substrates which provides further evidence against a subunit capture/chain mechanism for flagellar assembly. https://t.co/xsaVvWCLWO

[Stephen Garrett @StephenRG97]

Very happy to share some work from my PhD which is now published in Nature Communications! We have identified a new type of T7SS substrate which has a strange ‘reverse’ secretion signal. https://t.co/dczyneOdIN

[Owain James Bryant @OJ_Bryant]

Check out our new paper @ https://t.co/CjoPwrSp6V from my time working in the fantastic Chung lab @TranslatingRNA. Also check out our "Behind the Paper" post https://t.co/mw2EKOQtSK.
@ Filip Lastovka, @TranslatingRNA, @CamPathology, @OJ_Bryant. More to come from us soon!

[Lea Lab @LeaLabTweets]

Fantastic opportunity to join a vibrant new lab at a great institute (we may be biased).

[Francis O'Reilly @FJ_OReilly]

💥We're hiring! Two fully-funded postdoc positions at my lab at the NIH intramural program in Frederick, MD. We are mapping the structure of whole proteomes using crosslinking MS and structure modeling.

At one of the most dynamic scientific institutes! Links are below.

[Lea Lab @LeaLabTweets]

Last, but not least, some methods development. Real time analysis of single particle cryoEM data collection in SIMPLE 3.0.

https://t.co/27RLCTRRTq

[Lea Lab @LeaLabTweets]

We are recruiting! Come join us in beautiful Frederick. https://t.co/HtLUb8kJ2y

[Lea Lab @LeaLabTweets]

And one more time to bacterial motility, with the companion paper to the gliding motility paper. Here are cryoEM structures of the flagellar stator complexes that drive rotation of the flagellum.

https://t.co/nSg6GZtKBi