Lisa Schweizer

[Lisa Schweizer @LisaCSchweizer]

Beautiful work by @CarolineWeiss30/ @labs_mann, Mathias Uhlen, @MoritzScheidt & team! A cell type-resolved proteomic atlas of the human body - integrated into the @ProteinAtlas.

[Matthias Mann Lab @labs_mann]

1/5
Cell identity is written in the proteome, not in the DNA, and not always in the RNA. Out on bioRxiv today: The first cell type-resolved, MS-based proteomic atlas of the human body.
https://t.co/5RJ0nVoQ81

[Elizabeth McKenna @ElizSMcKenna]

Hear more from @MundAndreas about his recent @CD_AACR paper published online during #AACR26:

[Cancer Discovery @CD_AACR]

Now online: AI-powered Deep Visual Proteomics reveals critical molecular transitions in
pancreatic cancer precursors https://t.co/u5PgeZyitt

[Andreas Mund @MundAndreas]

Out now in @CD_AACR, timed with my #AACR26 talk.

Deep Visual Proteomics across the full PanIN → PDAC progression. 5,800+ proteins per region from 50–100 cells, 9,181 across the dataset. Normal ducts next to cancer aren't normal. Mass spec reads KRAS hotspot mutations directly off the protein.

https://t.co/BN80CNqoER

[Lisa Schweizer @LisaCSchweizer]

On time for #AACR26 – now online in Cancer Discovery (@CD_AACR): our manuscript on the proteomic landscape of pancreatic cancer precursors revealing critical molecular transitions. Thank you to the entire team for this strong collaboration: @OmicVision, @Aiims1742 , @jiminmin_v

[Cancer Discovery @CD_AACR]

Simultaneous #AACR26 publication online: AI-powered deep visual proteomics reveals critical molecular transitions in pancreatic cancer precursors https://t.co/nGUSpiREwx
By session speaker @MundAndreas, Jimin Min, Lisa Schweizer, @Aiims1742 & colleagues @NYULangone @omicvision

[Lisa Schweizer @LisaCSchweizer]

Exciting new #DVP study on the origins of high-grade serous ovarian cancer (#HGSC). Extracting as few as 12 mutated cells from precursor lesions and profiling consecutive tumorigenesis, this study took a formidable technical challenge and identified novel therapeutic targets.

[Matthias Mann Lab @labs_mann]

Spatial proteomics & transcriptomics chart #ovariancancer evolution from fallopian tube precursors. Deep Visual Proteomics reveals early SUMOylation, TRIP13 epithelial driver, BGN therapeutic target & epithelial-stromal cooperation in progression.
https://t.co/1BRGGNeWJy

[Matthias Mann Lab @labs_mann]

New preprint reveals why IDO1 inhibitor trials failed! Led by Peter Murray @MPI_biochem, our collaboration discovered IDO1 actually kills ovarian cancer cells via GCN2/ISR pathway - not protecting them. Spatial proteomics uncovers unexpected biology.
https://t.co/PdncQOV9P6

[Lisa Schweizer @LisaCSchweizer]

Check out the current issue of @Cancer_Cell featuring our work on the malignant progression of borderline ovarian tumors on its cover.
A team effort between @OvCa_UChicago @uchicago_obgyn and @labs_mann @MPI_Biochem.

[Lengyel Lab @OvCa_UChicago]

We’re proud to share that our lab’s recent publication by @LisaCSchweizer & @ErnstLengyel was selected for the cover of @Cancer_Cell! The artwork illustrates the malignant progression of borderline ovarian tumors to LGSOCs.

Read it here: https://t.co/Og9ar29WHS

[Cancer Cell @Cancer_Cell]

Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression https://t.co/4dXnlEB197

[Lisa Schweizer @LisaCSchweizer]

Excited to see this masterpiece out @Nature today. In this study, @JannaHeide, @AndrasPiffko, @ErnstLengyel & colleagues @OvCa_UChicago unraveled molecular mechanisms of NNMT in ovarian cancer and developed a specific inhibitor. A highly promising therapeutic avenue.

[Ernst Lengyel @ErnstLengyel]

Proud to share our new @Nature study: We developed the 1st NNMT inhibitor that reprograms cancer-associated fibroblasts, boosting immune response & stopping tumor growth in ovarian cancer models, especially when paired with immunotherapy. @OvCa_UChicago

https://t.co/G2QtUZWPPN

[UChicagoCancerCenter @UCCancerCenter]

New study from @rweichselbaum and team show high-dose radiation triggers amphiregulin, a protein that weakens immunity and fuels distant cancer spread—pointing to new strategies for blocking its effects. @SeanPitroda @AndrasPiffko @UChicagoRadonc @Nature
https://t.co/MIHrXFATrB

[Anirban Maitra @Aiims1742]

Very excited to share our preprint on #AI directed Deep Visual Proteomics (DVP) on #PancreaticCancer precursor lesions (PanINs), in collaboration with @OmicVision @MundAndreas
Thousands of proteins from as few as ~100 precisely microdissected cells in archival samples!

[OmicVision @OmicVision]

New @biorxivpreprint ! With Dr. Maitra @Aiims1742 (@MDAndersonNews) & Nebraska Rapid Autopsy Program, we used AI-powered Deep Visual Proteomics to map early molecular changes in pancreatic cancer precursor lesions.

Read: https://t.co/M9hVIqKQi3

#SpatialMedicine #PDAC

[Sean Pitroda, M.D. @SeanPitroda]

📢 New in Cancer Cell: Radiotherapy is essential for local control—but can it unintentionally accelerate growth of distant metastases? We examine how RT-induced EGFR signaling and immune modulation may fuel metastatic progression.
🧠🧬🔬
Read: https://t.co/gCAjDKMcIb

[Lisa Schweizer @LisaCSchweizer]

Exciting opportunity for a postdoc position with the exceptional @NordmannThierry on the topic of inflammatory skin disease. A great and inspiring environment that I can highly recommend!

[Thierry Nordmann @NordmannThierry]

My lab is hiring a postdoc for translational research in inflammatory skin diseases using cutting-edge proteomics
Join us @MPI_Biochem. All the infos here 🔍
https://t.co/NWwWPqKgYm
Apply until July 23. Please RT.

[Cancer Cell @Cancer_Cell]

Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression https://t.co/bfnijCzeF5

[Lisa Schweizer @LisaCSchweizer]

@NordmannThierry @labs_mann @ErnstLengyel Thank you, Thierry — your support and inspiration have meant a lot to me throughout this journey.

[Lisa Schweizer @LisaCSchweizer]

@martamurgia @Cancer_Cell @labs_mann @ErnstLengyel Thank you, Marta!

[Lisa Schweizer @LisaCSchweizer]

I’m thrilled to share that the main work of my PhD has been published @Cancer_Cell! With @labs_mann & @ErnstLengyel, we analyzed the progression from ovarian serous borderline tumors to invasive cancer using spatial proteo-transcriptomics and identified new therapeutic targets.

[Matthias Mann Lab @labs_mann]

Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination.
https://t.co/H0gYSr1RIc

[Lisa Schweizer @LisaCSchweizer]

@ZanivanLab @Cancer_Cell @labs_mann @ErnstLengyel Thank you very much, Sara!

[Ernst Lengyel @ErnstLengyel]

Proud to share our latest work now in @Cancer_Cell. In collaboration with @MPI_Biochem, we map the progression from borderline ovarian tumors to low-grade serous ovarian cancer & propose a promising new therapeutic strategy.

https://t.co/k5p8cKBwUq

#LGSC #SBT