Principal investigator / Postdoc in neuro-oncology @MedUni_Wien. Former @hovestadt lab member @DanaFarber. Interested in molecular mechanisms in brain cancers.
Thrilled to share that our paper is out in @NatureCancer! We used #scRNAseq, multiplexed spatial imaging, and eCLIP to study the cellular cooperation and transcriptional network in C19MC-driven #ETMR.
@beck_lab, @FilbinMariella, @hovestadt & Kool labs.
https://t.co/frH47Ljsdd
1/
We identify distinct cellular cooperation of malignant cell types. Targeting this cooperation network with #FGFR and #NOTCH inhibitors is highly effective in ETMR cells. Importantly, #erdafitinib therapy resulted in partial response in one heavily pre-treated ETMR patient.
6/
@gojojohannes@oeaw Incredibly grateful for your mentorship in my @FWF_at project and excited about our collaboration in this and many future projects. π