Lucas Pontel

Group Leader @CarrerasIJC, Barcelona 🧬 How cancer cells survive aldehydes, DNA damage and redox stress. Cancer metabolism · Fanconi anaemia

[Lucas Pontel @LucPontel]

Cells make toxic metabolites every minute they’re alive. How do they survive them?

In our @ScienceAdvances paper, we report that NRF2 coordinates the defences against genotoxic formaldehyde and ferroptosis resistance by regulating SLC7A11 (xCT)👇
https://t.co/EzbJn4KHyS

[Caroline Watson @carolinewatson]

How does leukaemia develop? 🩸 How long does it take? ⏳

🌟 Our paper, started back when I was a PhD student in @jrblundell’s lab, is out today in @Nature 🌟

Yearly blood samples from women who developed AML in later life let us trace it back decades 👇
https://t.co/fqyOpc5OKH

[FrezzaLab @FrezzaLab]

Good Sunday, all. An exciting set of papers in #cancermetabolism and #mitochondrialbiology is here, hot off the press. Find it here: https://t.co/MjWagYxP0V @Bims_BiomedNews @mitoworld_org #keepreading #keepthinking

[Josep Carreras Leukaemia Research Institute (IJC) @CarrerasIJC]

🔬 It's a wrap! Thank you to all speakers and participants for two wonderful days of science at the #IJCSymposium2026!

Congratulations to @eballestar, @BiolaMJavierre & @JTomasNavarro for organising such a successful event!

See you at the next IJC Symposium!

[Cris Muñoz & Ernest Nadal - PRETT lab @apoptosislab]

How do cells respond to glucose deprivation?
We focused on RAS-driven NSCLC and analyzed cell biology and transcriptional responses.
ATF4 and ATF6 dominate these transcriptional responses!
They regulated multiple metabolic genes, including metabolic enzymes and transporters

[FrezzaLab @FrezzaLab]

The tragic event unfolding this week in Spain makes it hard to focus on science. Here are some great papers in #cancermetabolism and #mitochondrialbiology in this weekly summary: https://t.co/iOtAoGVRHQ @Bims_BiomedNews @mitoworld_org #keepreading #keepthinking

[EL PAÍS @el_pais]

Marta Shahbazi dirige un grupo en el legendario Laboratorio de Biología Molecular de Cambridge, cuyos científicos han ganado una docena de premios Nobel. El equipo de la española ha iluminado los primeros días de la fecundación humana. Más información ➡ https://t.co/acEZUlnE9S

[Lucas Pontel @LucPontel]

Inspired by The Lord of the Rings: NRF2 (Sauron, the master controller), SLC7A11 (Saruman, the executor), and cystine (the orcs) — battling formaldehyde and fueling GSH to guard against ferroptosis. By @AgMorellato illustrating our @ScienceAdvances https://t.co/Ti3mEL4U7R

[Lucas Pontel @LucPontel]

Inspired by The Lord of the Rings: NRF2 (Sauron, the master controller), SLC7A11 (Saruman, the executor), and cystine (the orcs) — battling formaldehyde and fueling GSH to guard against ferroptosis. By @AgMorellato illustrating our @ScienceAdvances https://t.co/Ti3mEL4U7R

[Lucas Pontel @LucPontel]

@JoseL_Sardina @CarrerasIJC @ScienceAdvances Congrats Jose!!

[JL_Sardina_Lab @JoseL_Sardina]

1/ Excited to share our new study, steered by A. Lazarenkov @CarrerasIJC, out now in @ScienceAdvances!

TET2-driven AGO2 activation links epigenetic reprogramming to myeloid commitment and leukemia. 🧵👇

https://t.co/pAkHPeKpkw

[Lucas Pontel @LucPontel]

Cells make toxic metabolites every minute they’re alive. How do they survive them?

In our @ScienceAdvances paper, we report that NRF2 coordinates the defences against genotoxic formaldehyde and ferroptosis resistance by regulating SLC7A11 (xCT)👇
https://t.co/EzbJn4KHyS

[Lucas Pontel @LucPontel]

@ketanpatelimmo1 Thanks KJ !

[Lucas Pontel @LucPontel]

Big thanks to all the co-authors @AgMorellato @natalquezar et al @CarrerasIJC @hopkinson862 (@uniofleicester) @ucielp (@UICBarcelona), @roue_s, @IBioBA_MPSP + Funding sources @AgEInves @gencat @CONICETDialoga @Co_Biologists @CarrerasLeaders

[Lucas Pontel @LucPontel]

Cells make toxic metabolites every minute they’re alive. How do they survive them?

In our @ScienceAdvances paper, we report that NRF2 coordinates the defences against genotoxic formaldehyde and ferroptosis resistance by regulating SLC7A11 (xCT)👇
https://t.co/EzbJn4KHyS

[Lucas Pontel @LucPontel]

One import, two needs: cystine supplies for formaldehyde tolerance and GSH synthesis for ferroptosis defence.

Blocking cystine import and GSH synthesis together kills cancer cells from different tumors in vitro, and engrafted in a chick CAM (in ovo model).

[FrezzaLab @FrezzaLab]

Good Sunday, all. Another week of fantastic science has passed. Don't miss these breakthroughs in #cancermetabolism and #mitochondrialbiology, find them here: https://t.co/1OJw7Phvyp @Bims_BiomedNews @mitoworld_org #keepreading #keepthinking