Can a stem cell change its epigenome while proliferating? In our new preprint, in collaboration with the Tanay Lab, we demonstrate that the epigenome of neural stem cells is continuously remodeled, across multiple layers, during mouse corticogenesis. 1/14 https://t.co/D09GwqGWWS
I'm happy to share our work on the neurodevelopmental impact of ADNP mutations in #ASD and beyond. It has been an exciting ride to share with @AVitriolScience, Mariana, and the people of @gtesta72 and @raymondpoot Lab.
Full paper here: https://t.co/R2BGoQYHlI
Thread below 🧵
Thanks to @gtesta72 and @raymondpoot for bringing together such an enthusiastic and international team to work on this project, and for the smooth collaboration.
🚨New Preprint 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis — and how do they contribute to the evolution of the human neocortex?
Curious? 👇
https://t.co/z7OAyJSOWP
Led by Silvia Vangelisti @sinsy_ and Boyan
New #preprint alert from our lab!
We investigated how cellular context influences TF-driven epigenetic rewiring during neuronal differentiation.
Check it out here: https://t.co/0F3tnbZ0Fr
How do chromatin modifications quantitatively impact gene expression?
How do sequence variants or combinatorial marks influence relationships?
We developed a modular #EpigenomeEditing toolkit to systematically test these Q, published today 🧵…
https://t.co/2p4W0J50Oc
excited to share our latest work on the mechanisms of Gabriele-de Vries Syndrome #GADEVS a #neurodevelopmental condition we first described in 2017 https://t.co/clWGxtDl5z #RareDiseases /1
📢 We are hiring postdocs for our ERC SyG UNFOLD!!
Join the Borrell Lab to study the genomic bases of cerebral cortex folding @BorrellLab@NeuroAlc@CsicLifehub
Click here for job details and how to apply https://t.co/quVTF5OLkH
Do you want to investigate the link between chromatin mis-regulation and deseases?
Join us at CRG (in Barcelona) and apply for 4-years PhD fellowship in our lab. More info here: https://t.co/rneMNQZ9gt