I'm a cardiologist. Everyone is sharing this study as a skin story. They're burying the part that matters.
Scientists took the aorta of a 75-year-old donor, applied a single engineered enzyme, and stripped away more than 70% of the molecular damage — bringing it down to the levels you'd see in a 30-year-old artery.
Published five days ago in Nature Communications. Revel Pharmaceuticals, with Calico and the University of Colorado.
Here's what they erased.
Sugar reacts with proteins in your body the same way heat browns bread — slowly, over a lifetime. It leaves behind a residue called CML, the most abundant advanced glycation end product in aging tissue. It welds itself onto collagen and elastin in your skin, your eye lens, and your arterial walls.
Two things follow. Your arteries stiffen. And CML latches onto a receptor called RAGE, which drives chronic inflammation — the exact fire I've been writing about for months as the engine of heart disease.
Since the 1980s this damage was considered permanent. Your body has no enzyme to remove it. Every existing approach only slows new damage from forming. Nothing touched what was already there.
So they built an enzyme that doesn't exist in nature. They screened 45,000 protein structures, then ran five rounds of directed evolution across more than 500 million variants until they had CMLase — a molecular lawnmower that oxidizes the CML off the protein and restores the original, healthy lysine underneath.
Not patched. Reversed.
Over 70% cleared from elderly arterial tissue. Over 55% from elderly skin — below the levels found in 31-year-old skin. 45-78% in lens proteins. The CEO said they expected 20% and were floored.
Arterial stiffness drives systolic hypertension, heart failure, and stroke, and I have no drug that reverses it. I can slow the process. I cannot undo it. This paper says undoing it may be possible.
The caveats are real and I won't skip them. This was done on donated tissue in a dish, not in a living person. No functional data yet — we don't know if that artery got measurably more elastic. Delivering a large enzyme deep into human tissue is a hard, unsolved problem. Clinical trials are years away.
But something considered permanent for forty years just came off human tissue.
We spent a century learning to slow aging. Someone finally figured out how to erase it.
Thank you @theallinpod@friedberg@chamath@pesottas
Thankfully I have numbers rather than opinions.
The average number of days per year in the U.S. reaching 95°F was ~18% lower during the 60-year period 1961 to 2020 compared to 1901 to 1960.
The number of days reaching 100°F and 105°F have also declined since 1895.
I am in tears. President Trump just announced our VETERANS will replace illegals as truck drivers ❤️
“Any American that’s driven a heavy truck for our military is automatically eligible for a commercial drivers license”
THIS IS HUGE NEWS 🔥
Chamath: "Now, can I just say something else? You’re allowed to disagree with the guy… But as an adult living human being that’s responsible for taking care of your family, you have to get past the TDS."
Once we have completed our review for security vulnerabilities, we will make the entire codebase of 𝕏 open source, with no exceptions.
Moreover, we will invite third party reviewers to examine the system that is running to confirm that the open source code is what is running.
Trust through total transparency is the only thing that should be believed.
THE BOMBSHELL VIDEO THAT SHOCKED AMERICA! 🛑 Donald Trump just broke the internet by reposting President John F. Kennedy’s prophetic warning about a “ruthless conspiracy” destroying the nation from within!
Tom Brady reveals the brutally honest talk he had with a Michigan sports psychologist that turned him from a benchwarmer into the GOAT.
Brady's transformation started with one change: the way he thought.
"I sit on the bench my first year, and I really had—I would call it—a lot of self-defeating attitudes and behaviors. I always had an excuse. 'Coach doesn't want me in there.'"
"I had a sports psychologist. His name was Greg Harden. I would go into his office every Tuesday, and he would say, 'Tom, I like you. You work hard, but you have a shitty attitude.'"
"'How about you start worrying about what you can control and stop talking about the other quarterbacks, stop talking about the coaches not putting you in.'"
"If they give you three reps, you do the best with the three you get. Quit bitching about you only getting three or you going in there with the backup receivers. No one cares.'"
"'You treat practice like it's a game. If you throw a touchdown in the two-minute in practice, you celebrate like it's the game.'"
Brady never approached it that way before. Then "sure enough" everything changed.
"Mmy energy started getting way better. I was bringing juice; I had the right attitude."
"Then all of a sudden, I'm bringing the juice, man. Every day, boom."
"That [mindshift] really helped me get better."
The road to 7 Super Bowl rings didn't start on the practice field; it started in that very office…
President Trump just posted this 💀😂
The image depicts him presenting a map to European leaders that shows Canada, Greenland, and Venezuela as U.S. territory.