Luke R. Smart

Hematologist for children and adults. Sickle cell doctor. Global health researcher. @ChildrensCBDI & @UCHealthNews.

[Luke R. Smart @LukeSmartMD]

@PTMcGann @BritSocHaem With two different types of malaria!

[Luke R. Smart @LukeSmartMD]

Preservation of cognitive function commensurate with non-sickle cell age matched controls. An undisputed functional outcome that will improve life trajectory in all domains.

[Pat McGann, MD @PTMcGann]

More evidence to support our “early and often” approach to hydroxyurea therapy for #SickleCellAnemia

Early hydroxyurea use is neuroprotective in children with sickle cell anemia https://t.co/uBiNDZijrK

[Luke R. Smart @LukeSmartMD]

Intriguing molecular murine mechanistic insights about effect of voxelotor administration on markers of renal injury in Townes model sickle mice. How would hydroxyurea interact with this model? DOI: https://t.co/XPrhgKDGmx

[Luke R. Smart @LukeSmartMD]

Small data set, but encouraging results that COVID vaccine is effective regardless of splenic function, hydroxyurea treatment or transfusions in people living with sickle cell disease
DOI: https://t.co/zy1YTOkr5a

[Luke R. Smart @LukeSmartMD]

@PTMcGann @DrPowerHays Impressive, and important work. Congrats!

[SickleInAfrica @SickleInAfrica]

#SicklecellAwareness: "Dear healthcare workers, inform a parent about #Hydroxyurea and how s/he can get help for their kids or relatives with SCD (SS genotype) and do it right: by the protocol". Dr Lawrence Osei-Tutu. Details: https://t.co/3v387WDCzk
@evansxamuzu

[The Warren Alpert Medical School @BrownMedicine]

A new combined pediatric and adult sickle cell program at Rhode Island and Hasbro Children’s hospitals led by @PTMcGann works to address the racism and medical neglect patients face. #SickleCell @HasbroChildrens @RIHospital

https://t.co/KUquEKuqfq

[Luke R. Smart @LukeSmartMD]

Interesting to see this 10 years after the FEAST trial evaluated fluid resuscitation in sub-Saharan African children (DOI: 10.1056/NEJMoa1101549). @KathMaitland

[NEJM @NEJM]

In this trial, a restrictive approach to intravenous fluid administration in critically ill patients with septic shock did not reduce mortality. #CCR22 https://t.co/UfY1936Qwb

[The Lancet Haematology @TheLancetHaem]

Second day at the #GCSCD2022 Prof Ambrose Wonkam talks about genomics and therapeutics for #SickleCell disease

You can read his Review cited in the presentation here https://t.co/QNpVarOSEJ

[SickleInAfrica @SickleInAfrica]

SickleInAfrica's Dr Siana Nkya, Research Technical Lead at SPARCo CCC & former @Fogarty_NIH Fellow, is making noticeable contributions to #SickleCell research. She helped develop the 1st pilot SCD newborn screening program in Tanzania.@Sianaeli1. More:
https://t.co/sQQX67EO6M

[Pat McGann, MD @PTMcGann]

As if we needed more evidence to use hydroxyurea early, often, and globally, @DrPowerHays presenting data from the REACH study demonstrating that hydroxyurea dramatically reduces transfusion

This is particularly relevant in Africa as blood is such a scarce and valuable resource

[Luke R. Smart @LukeSmartMD]

@PTMcGann @BrownMedicine @BrownUniversity An auspicious start!

[KEMRI-Wellcome @KEMRI_Wellcome]

Congratulations to @KathMaitland for the OBE award! A fitting recognition for your tireless efforts to improve #criticalcare across Africa including building capacity of African research leaders @imperialcollege, @IDeAL_KEMRI_WT @KEMRI_Kenya

[Luke R. Smart @LukeSmartMD]

Excellent overview highlighting the complexity of addressing anemia in sickle cell disease and the limits of our current understanding and therapeutic options.

[Julia Xu, MD, MScGH @JuliaXuMD]

Anemia worsens organ damage and quality of life in #SickleCell, yet the treatment of anemia requires a careful balancing act. Check out our new article discussing the role of anemia in #SCD in @BloodJournal! @nih_nhlbi @PittVMI @PittHemeOnc @PittDeptofMed https://t.co/46fGrQCdoS

[Luke R. Smart @LukeSmartMD]

Difficult to comprehend the influence of KOF, or a world without him. A man who achieved great things, yet remained approachable, inspiring and caring for colleagues and patients across continents.

[Global Sickle Cell Disease Network @GlobalSCDN]

It is with heavy hearts to share that Professor Kwaku Ohene-Frempong ( KOF) has passed away on Saturday, May 7, 2022. KOF was an advocate &leader in the global sickle cell community. We remember the tremendous commitment & visionary focus that KOF exemplified throughout his life.

[PedsHemeDoc @PedsHemeDoc]

Great summary of types of gene therapy by @jkw4444 at #ASPHO2022 - truly fabulous art 😍

[PedsHemeDoc @PedsHemeDoc]

This sums it up nicely #ASPHO2022 @DrPowerHays @PTMcGann

[Alexandra Power-Hays, MD @DrPowerHays]

Excited for the #ASPHO2022 clinical updates on #SickleCell

Happening now!