Jonathan Mcleod

Post Doctoral Fellow at @Queensu |
P.h.D in Kinesiology from @McMasterUniversity

[Jonathan Mcleod @MACleod_JC]

Absolutely thrilled to share our work recently published in NAR molecular medicine on identifying a non-coding RNA (ncRNA) signature associated with skeletal muscle remodelling. Below is a thread of some (but not all 😉) interesting findings https://t.co/D1JfR5XMPW

[Jonathan Mcleod @MACleod_JC]

The wait is finally over! I'm so happy to receive my @binding_broken copies of Malazan. They are incredibly beautiful. Also, my cat really enjoys the box 😂

[Jonathan Mcleod @MACleod_JC]

😂😂😂😂😂😂

[Peter H. Diamandis, MD @PeterDiamandis]

I’m 63 years old, but biologically 39 --here’s how I reversed my age...

[Jamie Timmons @metapredict]

& note Illumina seq only measures in total 20% of lncRNA & each muscle illumina seq can't reproducibly that 20% (different set each spin of the wheel) as you can see from Jon's plot.

[Jonathan Mcleod @MACleod_JC]

I just want to say a huge thank you to all the co-authors on this project, none of this work would have been possible without you. @metapredict @mackinprof @ChanghyunLim1 @tjstokes5 @AlyshaDSouza1 @drlaurencs1 @james_mckendry @RobMorton23 @saraoikawa and many others not on X 🙂

[Jonathan Mcleod @MACleod_JC]

Absolutely thrilled to share our work recently published in NAR molecular medicine on identifying a non-coding RNA (ncRNA) signature associated with skeletal muscle remodelling. Below is a thread of some (but not all 😉) interesting findings https://t.co/D1JfR5XMPW

[Jonathan Mcleod @MACleod_JC]

We used 437 resting human skeletal muscle samples in a robust network analysis and found that some of our ncRNA candidates mediate their association with muscle growth via multiple different cell types (e.g., CYTOR is associated with an enriched immune cell network/response).

[Dr. Myohead @DrMyohead]

Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling

Fm @MACleod_JC @ChanghyunLim1 @tjstokes5 @AlyshaDSouza1 @james_mckendry @RobMorton23 @saraoikawa @metapredict @mackinprof

https://t.co/8ZQPHolT1F

[Jamie Timmons @metapredict]

Detailed illustration of how modelling of bulk transcriptomic data (Custom Affymetrix HTA & no not random WGCNA) provides information about rare cell types (<1% of bulk)

@MACleod_JC studies long noncoding RNAs during muscle hypertrophy - 90% missed by illumina bulk RNAseq @thermofisher

Network-based modelling reveals cell-type enriched patterns of non-coding RNA regulation during human skeletal muscle remodelling https://t.co/b8kYS3p8QJ

[Alejandro Adem @alejandroadem]

Excellent visit to @queensu today, thx to Principal Patrick Deane and the inspiring faculty and students for the great hospitality. Enjoyed learning about dark matter from Art McDonald &amp; the lab tour with @cathleencrudden. Nice to see firsthand the impact of @NSERC_CRSNG funding.

[Stuart Phillips (he/him) @mackinprof]

Muscle matters: the effects of medically induced weight loss on skeletal muscle https://t.co/3XgrUaIC7k

[Columbus Blue Jackets @BlueJacketsNHL]

Johnny Gaudreau
Aug. 13, 1993 – Aug. 29, 2024

[Jonathan Mcleod @MACleod_JC]

This incredible project could not have been possible without the stellar co-authors! Huge shoutout to the senior authors and my mentors on this project @metapredict @mackinprof

[Jonathan Mcleod @MACleod_JC]

Check out our new pre-print (https://t.co/xBppWIsTyv) where we highlight #ncRNA in human skeletal muscle following supervised exercise training!!

[Jonathan Mcleod @MACleod_JC]

To provide functional context for these ncRNA genes, we used quantitative network modelling (using 437 baseline muscle samples) of protein coding genes and ncRNA genes and used spatial images to identify potential cell-specific locations!

[Jonathan Mcleod @MACleod_JC]

Books 1-3 purchased 🎉. It'll arrive in Canada tomorrow, right 😉? @binding_broken

[The Broken Binding | Bookstore @binding_broken]

WE ARE LIVE 🥳