Movement Disorders Clinical Practice

Movement Disorders Clinical Practice is the exclusively online Journal of the International Parkinson and Movement Disorder Society (MDS) @movedisorder.

[Movement Disorders Clinical Practice @MDCP_Journal]

PD is a disease of uncertainty, and intolerance of uncertainty drives anxiety, avoidance & ↓QoL.
Clinicians: ask about it!

It’s modifiable: CBT/ACT/mindfulness may help.

Treat the uncertainty, not just the motor symptoms https://t.co/6z7W1Wqcv1

[Movement Disorders Clinical Practice @MDCP_Journal]

New MDCP Pearl: Computer Vision Analysis for Objective Motor Assessment in Parkinson's Disease: A Retrospective Study https://t.co/6z7W1WpEFt

[Movement Disorders Clinical Practice @MDCP_Journal]

Motor improvement ≠ life improvement.
After STN-DBS, patients rated real-world functioning ~7.7/10—yet genetics (GBA) and sex tracked more with socio-occupational outcomes than the usual clinic scores.
We need outcomes that reflect living, not just moving. https://t.co/greUIpivzR

[Movement Disorders Clinical Practice @MDCP_Journal]

Cervical dystonia has 2 big phenotypes:
-Early onset (35y) = much worse pain/mood/QoL vs later onset (48y) — motor severity differences are smaller.
-Don’t “BoNT-and-bye”: treat the non-motor load. https://t.co/TbYDNbv70S

[Movement Disorders Clinical Practice @MDCP_Journal]

PD & fractures: we’re missing the mark.
Only 12% on bone protection pre-fracture → just 53% @48wks post-fracture.
-Men, rib #, care home residents = least treated
-Vertebral # drives treatment—but shouldn’t be the trigger
-Think bone health EARLY in Parkinson’s
https://t.co/yhVU1GMqW0

[Movement Disorders Clinical Practice @MDCP_Journal]

The Japanese anime character Naruto Uzumaki has for generations inspired children and adults. in this study Naruto's running style was observed and described in children and interpreted as a evidence of a cultural meme rather than a pathological disorder of movement. https://t.co/bu9MnXvHp1

[Movement Disorders Clinical Practice @MDCP_Journal]

Continuous subcutaneous apomorphine infusion (CSAI) may benefit selected patients with multiple system atrophy. In a French multicenter cohort (n=50), CSAI improved motor symptoms in 90% at 6 months, with acceptable tolerability. #MSA #Parkinsons #DAT #Apomorphine https://t.co/xDuNU9lJaJ

[Movement Disorders Clinical Practice @MDCP_Journal]

Among PDRD patients with significant palliative needs, nearly half had an ED visit and one in five were hospitalized annually. Home-based services were used by over a third. Acute care use remains substantial underscoring gaps in supportive care delivery. https://t.co/IATvsYoafR

[Movement Disorders Clinical Practice @MDCP_Journal]

Foslevodopa/foscarbidopa improves urinary disturbances, nocturia and quality of life in PD patients. Both overnight continuous dopaminergic stimulation and increasing the total dose of L-dopa contribute to improve overactive bladder. https://t.co/SUq8nCY2xc

[Movement Disorders Clinical Practice @MDCP_Journal]

The 'Swallow Tail Sign' gets an upgrade!
Absence of dorsolateral nigral hyperintensity on SMWI is a robust, reproducible marker of neurodegenerative parkinsonism—works early, survives real‑world controls, and fits existing MRI pathways! @movedisorder https://t.co/MS2Bo1dLzM

[Movement Disorders Clinical Practice @MDCP_Journal]

MRgFUS thalamotomy shows strong tremor control even in patients ≥80 — with 95.6% improving and side‑effect rates similar to younger adults.
Learning point: Age alone shouldn’t exclude MRgFUS; balance issues are common but usually improve or resolve. https://t.co/XirbXXBDjm

[Movement Disorders Clinical Practice @MDCP_Journal]

Two siblings with BCL11B‑related early‑onset dystonia showed striking, long‑lasting motor improvement after GPi‑DBS,with >50% BFMDRS-M reduction. A reminder that genetic dystonias can be highly DBS‑responsive—mutation type, phenotype & timing matter. https://t.co/W7AcWwUKtU

[Movement Disorders Clinical Practice @MDCP_Journal]

Exocrine dysfunction in PD is common & early—drooling, dry mouth/eyes, seborrhea, rhinorrhea, sweating & GI issues all reflect autonomic + α‑synuclein pathology.
Clinician tip: Ask about these symptoms—they’re underrecognized but highly impactful! https://t.co/9rwqOJdJdk

[Movement Disorders Clinical Practice @MDCP_Journal]

Subcutaneous foslevodopa/foscarbidopa (fLD/fCD) was thought to overcome systemic and nutritional complications of LCIG therapy, but peripheral neuropathy can still emerge.
Baseline + ongoing vitamin & nerve monitoring recommended! https://t.co/BRAV9BvXxN

[Movement Disorders Clinical Practice @MDCP_Journal]

New scoping review highlights how FXTAS remains under diagnosed in Latin America.
Key takeaways:
• Classic signs = ataxia & intention tremor
• Cerebral atrophy more common than MCP sign
• Atypical phenotypes (spasticity, PSP‑like, rapid dementia)
• Urgent need for better access to genetic testing & clinician awareness
https://t.co/Rhwa3Rlqzk

[Movement Disorders Clinical Practice @MDCP_Journal]

A global MDS member survey on career and work environment found pronounced gender disparities in the field. Data were proportionally representative of Pan-America, Asia-Oceania, Europe, and Africa. @movedisorder https://t.co/EzqCFxpyNa

[Movement Disorders Clinical Practice @MDCP_Journal]

New case series:In PD dementia,cognitive fluctuations were consistently time‑locked to hypotensive episodes on 24‑hr BP monitoring — independent of levodopa timing. Recognizing & treating hypotension may be key to improving cognition. @AMahajanMD @UCMovDis https://t.co/iN5V0YKelC

[Movement Disorders Clinical Practice @MDCP_Journal]

The Parkinson’s Pals program reduced loneliness and demoralization in pwPD after just 8 virtual sessions, while boosting student PD knowledge. Low‑cost, scalable psychosocial care in action! https://t.co/k974FmmwhU

[Movement Disorders Clinical Practice @MDCP_Journal]

New MDCP Pearl: Digital Gait Measures Discriminate People with Friedreich's Ataxia from Healthy Controls https://t.co/8O4DSj1Py5

[Movement Disorders Clinical Practice @MDCP_Journal]

Long-term data from 31 orthostatic tremor patients show that about half continued perampanel, experiencing better social functioning, mental health, and reduced pain. Benefits are meaningful, but side effects remain frequent and may outweigh the benefit in some OT patients. https://t.co/0cIz6eNQU2