MERT KALAORA

[MERT KALAORA @MERTKALAORA]

@GTA6_Turk Banlanırsa banlansın sikerim online oyununu
Boşverin arkadaşlar kırın geçin
Oyunlar sizin olsun istediğinizi oynayın

[MERT KALAORA @MERTKALAORA]

@temettuhayalim Sıra o siktiğimin çikolatasına gelenee kadaaarrrrr ohooooo
Siz Türkiye'nin ahır olduğunu yeni mi öğrendiniz ?

[MERT KALAORA @MERTKALAORA]

@dylan2045ad @Polymarket Nooo
Those brainless Europeans are afraid because, if the criminals’ identities are revealed, they’ll be forced to catch them.
If your phone is stolen in Sweden, the UK or France, the police simply brush the matter aside, saying there’s no budget.
Europe disgusting shithole 🤣🤣

[MERT KALAORA @MERTKALAORA]

@NikolaTessla7

[MERT KALAORA @MERTKALAORA]

@mtudg3 Bu oyuna nasıl halan Türkçe dublaj yapamadı bizim modcular yaaa :(

[Brian Roemmele @BrianRoemmele]

THIS IS BIG!

The Cancer Cells That Changed Their Minds

A KAIST team just reversed cancer without killing a single cell — and the method may matter more than the result.

For a century, oncology has had exactly one strategy: find the cancer and destroy it.

Chemotherapy poisons it. Radiation burns it. Surgery cuts it out. Immunotherapy teaches the body to hunt it. Every weapon differs in precision, but not in philosophy. The tumor is an enemy. You win by killing.

Now a team at South Korea's KAIST has proposed a heresy: *what if the tumor doesn't need to die?*

In a study led by Professor Kwang-Hyun Cho of the Department of Bio and Brain Engineering, published in Advanced Science ("Control of Cellular Differentiation Trajectories for Cancer Reversion," DOI 10.1002/advs.202402132), researchers took colon cancer cells and — without poisoning, irradiating, or cutting them — turned them back into normal cells.

Not dead. Not damaged. Just normal again.

The tumors, grown in mice, shrank dramatically. The surrounding tissue was left intact, because there was never an attack to survive.

This is early research — cell lines and animal models, no human trials, real obstacles still unsolved. But the conceptual break is the story. For the first time, cancer treatment has a second verb. Not just destroy. Also: convert.

The digital twin of a cell

The KAIST team's insight begins with a redefinition of what cancer is.

The conventional view treats cancer as a pile of broken machinery: mutations accumulate, checkpoints fail, cells proliferate. Cho's group looked at the same evidence and saw something different — a trajectory. During oncogenesis, they observed, normal cells don't just break. They regress, sliding backward along the differentiation path they followed when they matured. A colon cell becomes, in effect, a confused stem cell: immature, proliferative, lost.

If cancer is a wrong turn on a developmental road, then the treatment question changes. You don't blow up the road. You build a map and find the turn.

That map is what the team calls a digital twin — a complete computational model of the gene network governing a cell's differentiation. Using data from 4,252 intestinal cells, they reconstructed a network of 522 interacting components, capturing how genes regulate one another as a cell matures or degrades.

Then they did the audacious thing: they asked the simulation which levers, flipped together, would push a cancer cell back down the road toward normalcy.

The answer came through a system they built called BENEIN (Boolean Network Inference and Control), which models gene interactions as logical relationships and systematically tests which interventions redirect the network's state. The simulation pointed to three master regulators — the genes MYB, HDAC2, and FOXA2 — acting together as the switch that holds the cancerous state in place.

Turn all three off simultaneously, the model predicted, and the cell would stop proliferating and differentiate into something resembling a normal intestinal cell.

They tested it, and it worked.

In three colon cancer cell lines, suppressing MYB, HDAC2, and FOXA2 together strongly induced differentiation into normal-like cells. The cancer cells began expressing markers of healthy intestinal tissue. Proliferation collapsed — not because the cells died, but because they grew up.

In animal models, tumors formed from the reprogrammed cells were dramatically smaller than controls, and under the microscope they looked far more like normal tissue. The signature achievement, and the one that would matter most to any patient reading this: there was no collateral damage. Nothing was poisoned, burned, or irradiated. The healthy tissue never came under fire, because there was no fire.

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[MERT KALAORA @MERTKALAORA]

@axhiii88547 MX linux best in best

[MERT KALAORA @MERTKALAORA]

@CallandorMat Çok aptal bi oyun yaw 😂
dash yapacak skill almadan(en dipte olduğunu bilmiyordum) finale kadar gidip asla bitirememiştim 🤣
Sonra YouTube çözüm videosunda bende olmayan özelliği görünce dank etti 😂
Geri dönüp o özelliği alınca bitirmiştim
Müzikleri ve görsel tasarım mükemmeldi

[MERT KALAORA @MERTKALAORA]

@grok @bosunatiklama Peki Türkiye gibi kayıt parası alan ülke var mı ?

[MERT KALAORA @MERTKALAORA]

@googleespanol GOD BLESS CHINA
Gemini, the world's dumbest AI.
If the AI industry belonged to America, we would still be carving stone right now.
Our world is progressing thanks to China.

[MERT KALAORA @MERTKALAORA]

@ardabalkandev Ama bunun fiyatı da şuanki m5 Max ile aynıydı 😂

[MERT KALAORA @MERTKALAORA]

@utkusen Eliot haklıydı demek...

[MERT KALAORA @MERTKALAORA]

@selimozgun Birisi şu dublaj nasıl yapılır diye YouTube videosu çeksin yaw
Niş oyunlarımı da dublaj yapmak istiyorum :(

[MERT KALAORA @MERTKALAORA]

@mesutcevik Doğru diyor
#Sony
#ps5

[MERT KALAORA @MERTKALAORA]

@Avenoxai Eğitim için kullanıyorlar olm bizi
Ama kendisini geliştireceği AGI seviyesine geldiği an hiçbiri ücretsiz olmıcak

[MERT KALAORA @MERTKALAORA]

@itsPaulAi Me : hello
Gravity: Your limit has been reached.

[MERT KALAORA @MERTKALAORA]

@bosunatiklama Alla alla nasıl olur yaw ?

[MERT KALAORA @MERTKALAORA]

@BBCWorld

[MERT KALAORA @MERTKALAORA]

@waldenthewizard Sony o kadar tecrübe kazanıyorki şuan ps6 asla kırılamayacak