Maria Andrianova

Cancer cell biology | Mutagenesis & repair | postdoc in # @bbglab @IRBbarcelona

[Vladimir Seplyarskiy @seplyarskiy]

Excited to share our preprint: Cohort-level analysis of human de novo mutations points to drivers of clonal expansion in spermatogonia!

We developed methods to uncover drivers of clonal expansions in sperm (CES) using 55k disease trios & gnomAD SNV data.
https://t.co/M5Ojbdn4Ya

[Mike Spencer Chapman @doctor_msc]

Stem cell transplants are amazing. A patient's diseased blood is replaced by a relative or stranger's. But what does putting a blood system into a new body do to the cells? How many survive? Does it matter?

Out in @Nature today, we asked some basic Qs 👇

https://t.co/anRQGeo2qq

[Maria Andrianova @MaAndrianova]

The new work from our @bbglab about the main factors predicting response to immunotherapy is out in @NatureGenet! Big congrats to Joseph Usset and all the team! 🎉 It was an interesting and valuable experience for me to take part in it.

[IRB Barcelona @IRBBarcelona]

💡Five key factors predict the response of #cancer patients to #immunotherapy

✍️ @fmuinos @abel_gonzalezp @nlbigas et al.

📰@NatureGenet

➡️https://t.co/vOnWLJ9BCd

📌DOI: 10.1038/s41588-024-01899-0

#IRBScience #CancerResearch

[Georgii Bazykin @GBazykin]

I am excited to share that I will be starting a lab at @EmoryUniversity this September. We will aim to understand evolution by studying genomes of things ranging from viruses to humans. Looking for talented students and postdocs to do computational genomics. Get in touch! 1/2

[Maria Andrianova @MaAndrianova]

Now it is out in Cancer Discovery! Congratulations to all the authors!

[Santi Demajo Meseguer @SantiDemajo]

📢 Very happy to share our latest paper Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis, just published in Cancer Discovery

Explore our findings here: https://t.co/Q6KVa1UoIc 🩸🧬💻

[Maria Andrianova @MaAndrianova]

Our story about mutagenesis assosiated with POLD1 deficiency is published! Congratulations and great thanks to everyone involved!

[Vladimir Seplyarskiy @seplyarskiy]

Finally published. In this paper we showed that despite heterozygous exonuclease deficiency of pold1 has a minor effect on the germline and somatic mutation rate. Homozygous deficiency increase mutation rate by 2 orders of magnitude and causes cancer https://t.co/fFBK2eeMo8

[Mònica Sánchez Guixé @guixe_m]

Our work on the origins of second malignancies in children is out in Cancer Discovery @IRBBarcelona @bbglab @IRSJD_info
https://t.co/OICCeoTFOC
1/16

[Santi Demajo Meseguer @SantiDemajo]

❗️Our preprint “Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis” is out https://t.co/yJhtxpAbVl

Thrilled to present this study by @SantiDemajo @JoanEenric @fmuinos @miggrau @MaAndrianova @abel_gonzalezp @nlbigas in a tweetorial 👇🏽

[Vladimir Seplyarskiy @seplyarskiy]

Our germline mutation rate model have been published in @NatureGenet. Together with methods to estimate mutation rate, we designed novel validation metrics and characterized hypermutability associated with Pol III transcription.

[Inigo Martincorena @imartincorena]

I am looking forward to this documentary series by @Kat_Arney and @BBCSounds on cancer research. This first episode explores why we get cancer, with the help of mummies, dinosaurs, amoebas and naked mole rats.

[bbglab @bbglab]

With pleasure we share the group picture of our latest retreat. We had time to share a lot of thoughts and to have fun together.
We are ready now to follow with our research projects even with more energy!!

[Charles Swanton @CharlesSwanton]

Today our important study on air pollutants in the promotion of lung cancer has been published in @Nature led by @WillHilliam @LimEmilia @DrClareWeeden @SwantonLab ...Thread below🧵https://t.co/q1ICykmVox

[Ruslan Soldatov @_ruslansoldatov]

Very excited to share that I recently started my lab in @CompOncMSK at @MSKCancerCenter!

Looking for postdocs and graduate students interested in cell fate decisions/cancer evolution/computational single-cell genomics. Come join us in NYC!
Spread the word & please #RT. Thanks!

[Maria Andrianova @MaAndrianova]

Great thanks to @seplyarskiy, @LValleResearch, @GBazykin , @fkondras , Alexey Kondrashov and all other co-authors for making this work possible!

[Maria Andrianova @MaAndrianova]

Our preprint about the influence of germline POLD1 deficiency on germline and somatic mutagenesis and cancer development is finally out!

Great summary from @seplyarskiy ⬇️

[Vladimir Seplyarskiy @seplyarskiy]

Our preprint about the role of POLD1 deficiency in soma and germline mutations is out. https://t.co/wXq3PDrQyM

Two main findings: surprisingly, POLD1 deficiency has a recessive effect on mutation rate; POLD1 alters mutational spectra to the same degree in soma and sperm