Prabodhika Mallikaratchy

The Mallikaratchy lab uses programmable molecular tools based on nucleic acid aptamers (NAAs) to understand the fundamentals of bio-molecular interactions.

[Prabodhika Mallikaratchy @MalikaratchyLab]

https://t.co/iHmcm4oJYi

[Prabodhika Mallikaratchy @MalikaratchyLab]

@EVydaline thesis project is live on BioRxiv! Aptamers against native-state β2AR using an advanced LIGS variant. Proud of Vydaline and the whole lab! Grateful to@NIGMS_NIH for supporting this work and the G-RISE and U-RISE training grants.@CUNYMed @GC_BiochemPhD @GC_CUNY @CUNY

[WashU Medicine Anesthesiology Research @WashUAnesRsrch]

Join us for the @ClinicPharmSTL Research Seminar featuring Dr. Prabodhika Mallikaratchy from @CUNYMed @MalikaratchyLab

Details ⬇️

📆 Wednesday, April 23
⏰ 1-2 p.m.
📍 UHSP Academic and Research Building room 222

https://t.co/0fn3GqttTU

[Prabodhika Mallikaratchy @MalikaratchyLab]

Congratulations to Dr Vydaline Agbor Otu on her excellent PhD defense! She spearheaded and successfully completed a difficult project while also managing the challenges of raising a family. An incredible achievement and a true testament to her dedication and perseverance!🎉🎉🎉

[Prabodhika Mallikaratchy @MalikaratchyLab]

Happy Holidays from the Mallikaratchy Lab!
We gathered as many of us as possible to celebrate a year filled with fun, and exciting science. Wishing you all a wonderful holiday season! @CUNYMed @CUNY @GC_CUNY

[Prabodhika Mallikaratchy @MalikaratchyLab]

And last but not least—our 3rd Fall publication 🎉 A study from a new branch of our lab exploring modified nucleic acids, their functions, and applications, led by our amazing team of students & postdocs!@SURESHLINGALA13 @CUNY @CUNYMed 🔬👏 | ACS Omega https://t.co/uRgx9ou6xU

[Prabodhika Mallikaratchy @MalikaratchyLab]

Our 2nd publication this Fall explores the function of CD19/CD20 aptamers generated by LIGS 🔬 Led by our talented student Yilam... @CUNY @GC_CUNY @CUNYMed
https://t.co/1pw0hLXOsg

[Prabodhika Mallikaratchy @MalikaratchyLab]

Excited to share 3 publications from our lab this Fall! 🎉
First up: a comprehensive review on aptamers ad delivery agents, led by our talented students Vydaline, Sergei, and German 👏
@GC_CUNY @CUNYMed @EVydaline
https://t.co/JF3cPsAdTe

[nature @Nature]

A US Senate committee endorsed maintaining the NIH's structure and increasing its funding by US$400 million, or about 1%

https://t.co/msFUhHbsJW

[J. Am. Chem. Soc. @J_A_C_S]

On the cover of this week's issue: "Chirality-Promoted Chemical Ligation and Reverse Transcription of Acyclic Threoninol Nucleic Acid"

Read it here 🔗 https://t.co/hnwSrTp6dy

[Michael 英泉 Eisen @mbeisen]

Very happy that the long, long, long, long, long overdue day when the published results of all @NIH funded research is immediately freely available to everyone who can benefit from it. Kudos to the @NIH for making this happen, and eternal curses to the scientific societies, publishers and research 'leaders' who spent 30 years wielding their influence to block this, for the immeasurable harm to scientific progress and public trust in science they have wrought.

[Prabodhika Mallikaratchy @MalikaratchyLab]

@biorxivpreprint @DNAnanoscience @WONDER_DNA

[Prabodhika Mallikaratchy @MalikaratchyLab]

We are excited to share our preprint, which was led by the incredibly talented student, Yilam Ng Cen.
The biochemical function of bivalent aptamer assemblies against B-cell markers CD19 and CD20 https://t.co/i143RCzOww

[Prabodhika Mallikaratchy @MalikaratchyLab]

@CUNYMed @GC_CUNY @CUNY

[Prabodhika Mallikaratchy @MalikaratchyLab]

This is just the first of several studies in this direction from our lab—stay tuned for more exciting work! Huge thanks to our super fantastic team for making this possible! @SURESHLINGALA13 @MohanraoRaja @CUNYMed @CUNY @GC_CUNY @biorxivpreprint

[Prabodhika Mallikaratchy @MalikaratchyLab]

Additionally, we uncovered new biochemical insights into the duplex’s promiscuity toward DNase I and two restriction enzymes, which might be governed by observed conformation switch. @DNAnanoscience @WONDER_DNA

[Prabodhika Mallikaratchy @MalikaratchyLab]

Using CD spectroscopy, we show that these modified duplexes adopt unique conformations, with the linker connecting the indole playing a key role in this conformational adaptation.

[Prabodhika Mallikaratchy @MalikaratchyLab]

We are thrilled to share our second preprint exploring one of the exciting new directions in our lab! In this study, we synthesized indole-modified C-5 pyrimidines and C-8 purines, and strategically incorporated them into a 15-mer duplex.
https://t.co/s46ltfSGkF

[Prabodhika Mallikaratchy @MalikaratchyLab]

@disney_lab Morning run in New York today

[Prabodhika Mallikaratchy @MalikaratchyLab]

@rymarwil We also did Secret Santa in our lab!!!