The Mallikaratchy lab uses programmable molecular tools based on nucleic acid aptamers (NAAs) to understand the fundamentals of bio-molecular interactions.
@EVydaline thesis project is live on BioRxiv! Aptamers against native-state β2AR using an advanced LIGS variant. Proud of Vydaline and the whole lab! Grateful to@NIGMS_NIH for supporting this work and the G-RISE and U-RISE training grants.@CUNYMed@GC_BiochemPhD@GC_CUNY@CUNY
Join us for the @ClinicPharmSTL Research Seminar featuring Dr. Prabodhika Mallikaratchy from @CUNYMed@MalikaratchyLab
Details ⬇️
📆 Wednesday, April 23
⏰ 1-2 p.m.
📍 UHSP Academic and Research Building room 222
https://t.co/0fn3GqttTU
Congratulations to Dr Vydaline Agbor Otu on her excellent PhD defense! She spearheaded and successfully completed a difficult project while also managing the challenges of raising a family. An incredible achievement and a true testament to her dedication and perseverance!🎉🎉🎉
Happy Holidays from the Mallikaratchy Lab!
We gathered as many of us as possible to celebrate a year filled with fun, and exciting science. Wishing you all a wonderful holiday season! @CUNYMed@CUNY@GC_CUNY
And last but not least—our 3rd Fall publication 🎉 A study from a new branch of our lab exploring modified nucleic acids, their functions, and applications, led by our amazing team of students & postdocs!@SURESHLINGALA13 @CUNY@CUNYMed 🔬👏 | ACS Omega https://t.co/uRgx9ou6xU
Our 2nd publication this Fall explores the function of CD19/CD20 aptamers generated by LIGS 🔬 Led by our talented student Yilam... @CUNY@GC_CUNY@CUNYMed
https://t.co/1pw0hLXOsg
Excited to share 3 publications from our lab this Fall! 🎉
First up: a comprehensive review on aptamers ad delivery agents, led by our talented students Vydaline, Sergei, and German 👏
@GC_CUNY@CUNYMed@EVydaline
https://t.co/JF3cPsAdTe
On the cover of this week's issue: "Chirality-Promoted Chemical Ligation and Reverse Transcription of Acyclic Threoninol Nucleic Acid"
Read it here 🔗 https://t.co/hnwSrTp6dy
Very happy that the long, long, long, long, long overdue day when the published results of all @NIH funded research is immediately freely available to everyone who can benefit from it. Kudos to the @NIH for making this happen, and eternal curses to the scientific societies, publishers and research 'leaders' who spent 30 years wielding their influence to block this, for the immeasurable harm to scientific progress and public trust in science they have wrought.
We are excited to share our preprint, which was led by the incredibly talented student, Yilam Ng Cen.
The biochemical function of bivalent aptamer assemblies against B-cell markers CD19 and CD20 https://t.co/i143RCzOww
Additionally, we uncovered new biochemical insights into the duplex’s promiscuity toward DNase I and two restriction enzymes, which might be governed by observed conformation switch. @DNAnanoscience@WONDER_DNA
Using CD spectroscopy, we show that these modified duplexes adopt unique conformations, with the linker connecting the indole playing a key role in this conformational adaptation.
We are thrilled to share our second preprint exploring one of the exciting new directions in our lab! In this study, we synthesized indole-modified C-5 pyrimidines and C-8 purines, and strategically incorporated them into a 15-mer duplex.
https://t.co/s46ltfSGkF