Rob Manguso

Official twitter of the Manguso Lab @MGHCancerCenter @BroadInstitute @harvardmed, studying cancer immunology using functional genomics and systems immunology

[Rob Manguso @MangusoLab]

Super excited to share our latest work with @MarcelaMaus , out this week in @Nature. We show that in vivo CRISPR screens can identify genes that enhance the efficacy of CAR T cell therapy. Brief explainer below! @MGBResearchNews @broadinstitute

https://t.co/rUM3TAjkPu

[Rob Manguso @MangusoLab]

Overall, we help inform the development of new immune-based therapies targeting HNSCC. At the advanced stage this is a deadly cancer that is poorly responsive to current immunotherapy approaches.

[Rob Manguso @MangusoLab]

Our latest work on IO target discovery is out this week. Amazing collaboration with @DrUppaluri and led by Cong Fu. We performed in vivo CRISPR screens in #HNSCC to identify targets to enhance ICB response.
@MGHCancerCenter @broadinstitute @DanaFarber

https://t.co/pikSB4I2SE

[Rob Manguso @MangusoLab]

Interestingly, we find that deletion of Col17a1 alone (just 1 gene regulated by UCHL5) does enhance ICB response, although not to the same degree. Further, Col17a1 overexpression can reverse the ICB sensitivity seen in UCHL5 KO tumors.

[Ravi Uppaluri, MDPhD @DrUppaluri]

Congrats to DrCongFu ! Wonderful to collaborate with @MangusoLab on in vivo CRISPR of epigenetic targets study in #HNSCC models @NatureComms @kathleenbyates @IOTNmoonshot Thanks also to @SilvioGutkind @rsaddawi !! https://t.co/zE0QIL4Jtd

[Rob Manguso @MangusoLab]

@MarcelaMaus @Nature @MGBResearchNews @broadinstitute https://t.co/8ngbckDitT

[Rob Manguso @MangusoLab]

Super excited to share our latest work with @MarcelaMaus , out this week in @Nature. We show that in vivo CRISPR screens can identify genes that enhance the efficacy of CAR T cell therapy. Brief explainer below! @MGBResearchNews @broadinstitute

https://t.co/rUM3TAjkPu

[Rob Manguso @MangusoLab]

Congrats to Nelson Knudsen, @escobar_giulia, @FpkMd, and the entire team for the publication of their amazing work! And thanks for @MGHCancerCenter and @broadinstitute for the support!

[Rob Manguso @MangusoLab]

Obviously this is a super exciting and fast moving space with all the great work coming out this week. We're happy to be helping to advance our understanding of therapeutic T cell biology, and there will be more to come!