Marc Halfon

[Marc Halfon @MarcHalfon]

Today is Holocaust Memorial Day. It's sobering on this day to reflect this week, the U.S. has (1) proposed a Federal registry of people with autism & (2) sent a questionnaire to Barnard employees asking if they are Jewish. https://t.co/MFSO5vclBe... https://t.co/OxYsC035FI...

[REDfly @REDfly_database]

ICYMI: REDfly database has moved to Bluesky! Follow us at https://t.co/Yz5KMDTwKL for news and updates. Come try our new Search interface (beta) at https://t.co/bV6dissXCA

[REDfly @REDfly_database]

REDfly is moving to Bluesky! Please follow us at @redfly-database.bsky.social for all our latest updates
#drosophila #arthropods #genomics #gene-regulation

[REDfly @REDfly_database]

Major new update! Not only did we add ~50 new reporter constructs and update info on over 800 more, we introduced the beta version of our new Search and Download interface with vastly expanded and improved functionality. Try it out!
#cisreg #enhancers #drosophila

[EvoDevo PanAm @EvoDevoPanAm]

Another opening @michiganstateu Assistant Professor for functional genomics! Non-traditional models are encouraged. #evodevo #genomics

[Marc Halfon @MarcHalfon]

Our first µPublication! Kudos to Geyenna for her thorough analysis of this region and recognition that what at first appeared to be just another enhancer is more likely a sequence with a different regulatory role. Hopefully we will have more on this story in the near future.

[microPublication @Micropub7n]

Identification of a novel downstream single-minded midline regulatory element in Drosophila melanogaster #micropublication #biology #data #caltechlibrary #Drosophila #Genomic #NewFinding https://t.co/A9yUiL6A2z

[Marc Halfon @MarcHalfon]

We will continue to add new annotations and new species, with the data available via @REDfly_database. A detailed protocol will be available shortly in @PLOSONE (Asma et al. 2024), so you can try it too! (3/3)

[Marc Halfon @MarcHalfon]

Excited to report the final version of our paper out today:
In @eLife: Regulatory genome annotation of 33 insect species https://t.co/F3Na7OWCUg
Kudos to all involved in this monumental effort that provides a preliminary regulatory annotation of 33 insect genomes. (1/3)

[Marc Halfon @MarcHalfon]

We use the machine-learning SCRMshaw method trained on Drosophila enhancers (from @REDfly_database ) to predict enhancers across the holometabolus insects (and some Hemiptera!). Various different metrics, including in vivo reporter-gene validation, suggests good accuracy. (2/3)

[Marc Halfon @MarcHalfon]

How cool is it that @Co_Biologists plants trees to acknowledge reviewers?

Just protected

For a peer review by Marc Halfon

https://t.co/9cohog1oFn

[Marc Halfon @MarcHalfon]

#PrideMonth seems like a good time to restate that Everyone is Welcome in the Halfon Lab and on the @REDfly_database team!

[Marc Halfon @MarcHalfon]

Kudos to Bill and Geyenna on their beautiful writeup of our protocol for working with #Aedes aegypi embryos, complete with detailed how-to videos!

[Marc Halfon @MarcHalfon]

#PLOSONE: Improved methodology for fixation and preparation of Aedes aegypti embryos https://t.co/1L49SKn87p

[Marc Halfon @MarcHalfon]

#PLOSONE: Improved methodology for fixation and preparation of Aedes aegypti embryos https://t.co/1L49SKn87p

[Marc Halfon @MarcHalfon]

Wife profiled in ASCO Post: https://t.co/8EUN34hXx3

[UBuffalo Center for Computational Research @UBCCR]

The deadline for applications to our summer workshop has been extended to May 24th. Please help us get the word out!

[Marc Halfon @MarcHalfon]

Very happy to share that our paper on regulatory #evolution of the #Drosophila and #Aedes aegypti sim locus is out today in @PLOSGenetics. Kudos to Isabella, Bill, and Geyenna for tackling this massive project and bringing #mosquito genetics to our lab!
https://t.co/LLE4YZp1Df

[Molecular Instruments @HCRimaging]

This week’s #FluorescenceFriday #onlywithHCR spotlight is on Marc Halfon! #HCRimaging enabled @MarcHalfon to obtain more accurate results (over those obtained from traditional whole-mount ISH techniques), as he and his team were able to prove using orthogonal methods like CRISPR-inserted GFP gene fusion.

Check out his latest manuscript here: https://t.co/pawsi67wnZ

[David Bilder @bilderlab]

We're hiring a research tech. 
Great for a post-bac interested in genetics, development or cancer biology. 
https://t.co/BLLcJYzJ5B
Will update w/ official posting but feel free to reach out now, esp. candidates w/ model organism experience #drosophila.

Please RT.

[Marc Halfon @MarcHalfon]

@AnyiMazo @EvoDevoPanAm Congratulations Anyi!

[Marc Halfon @MarcHalfon]

Kudos to former PhD student Isabella Schember for tackling the new world of mosquito biology for us and persevering through a pandemic, lab move, and many other hurdles to move this work along!

[Marc Halfon @MarcHalfon]

Our latest paper: we cloned two enhancers for #Aedes aegypti sim and demonstrate function in vivo in transgenic #mosquitoes.

Conserved and novel enhancers regulate expression of Aedes aegypti single-minded in the embryonic ventral midline https://t.co/YQA1A3odtb

[Marc Halfon @MarcHalfon]

One enhancer looks just like the ones known in #Drosophila. One is completely different wrt location, mechanism, and cell-type specificity. Continued exploration of these two loci should provide a lot of insight into how regulation of conserved developmental TFs evolves.