Alexander Stark

[Anshul Kundaje @anshulkundaje]

Just want to give a shout-out to David Kelley @drklly who I think often does not get the credit he deserves (outside our core community).

I want to highlight why I think he is such a fantastic scientist and leader in regulatory genomics. 1/

[Alexander Stark @AlexanderStark8]

@ERC_Research Emilie Caspar’s ERC endorsement cynically - but not unrealistically - adjusted to recent news: “High-risk ideas are often the ones that lead to ERC B evaluations and 2-year bans”

[Alexander Stark @AlexanderStark8]

@leslievosshall @JakubTomek13 @hhmi_science @qedScience @biorxivpreprint I tried qed science and found it’s feedback unusable without expert supervision.

[Mauricio Contreras @mpcontreras4]

@KamounLab @ERC_Research Not to mention the ridiculous move to open an "ERC Plus" scheme rather than invest more money into the already well functioning programs to fund more research.

[Alexander Stark @AlexanderStark8]

@ERC_Research Further and further in the wrong direction. Quo vadis @ERC_Research? Since years, there have been alarming trends about ERC fund allocation between fields and career stages. And now 2-year bans for unsuccessful applications, all based on unavoidably imperfect panel decisions 👎

[Yasin Dagdas @PlantoPhagy]

This gives incredible power to the panelists. They will literally determine if a lab survives or not with the 3 year ban. I don't think a couple of people should have this power. @ERC_Research

[Dr Ino Agrafioti @inoagrafioti]

I don’t know if you saw the MASSIVE news announced by @ERC_Research today: from now on,if you get a B at step 1 you are eligible to apply at N+3(!!!) years. Say you got a B in STG2026 step 1, you thought you could apply in STG2028, but no: only in STG2029! https://t.co/GccJx6iQQh

[Jacob Schreiber @jmschreiber91]

@garrytan It's always nice to see more people in this space, but "barely touched territory" seems exaggerated. To design these enhancers, they use a model from a paper that also does AI-based enhancer design! And they provided wetlab validation of their sequences.

[Jacob Schreiber @jmschreiber91]

The Programmable Genomics Lab at @UMassGCB
just officially launched our site!

We have a "simple" goal: to develop synthetic regulatory elements that target every cell type in every tissue, and control payload dosage/duration

Check it out!
https://t.co/Ito7awthSF

[Oded Rechavi @OdedRechavi]

The way to accelerate science is to SLOW it down.

Fewer papers please! We’re drowning in meaningless text.

One GREAT paper per lab per decade is more than enough.

q.e.d 👇

[Alexander Stark @AlexanderStark8]

@OdedRechavi I would NOT want q.e.d. be my reviewer

[Alexander Stark @AlexanderStark8]

@OdedRechavi in my experience q.e.d. provides interesting feedback but is essentially useless without expert interpretation. it comes up with all kinds of nitty gritty stuff

[Žiga Avsec @Avsecz]

AlphaGenome is out in @nature today along with model weights! 🧬

📄 Paper: https://t.co/1fHzSPiY1x
💻 Weights: https://t.co/z6JWLT4Mpv

Getting here wasn’t a straight path. We sat down @googledeepmind to discuss the story behind the model, paper & API: https://t.co/cT8CiXfnxQ

[Alexander Stark @AlexanderStark8]

@fiddle @MoffittLab @CSHL Deadline TODAY January 23 - please join the Systems Biology: Global Regulation of Gene Expression meeting in beautiful @CSHL (March 11-14). Register and submit your abstract here: https://t.co/4Ei0Efq1oG. Please Repost!

[Alexander Stark @AlexanderStark8]

Join @fiddle, @MoffittLab, @sara_mostafav, me and all speakers for the 2026 CSHL meeting Systems Biology: Global Regulation of Gene Expression, March 11-14. Abstract deadline January 9! More infos and registration at https://t.co/4Ei0Efqzee

[Alexander Stark @AlexanderStark8]

@fiddle @MoffittLab Deadline extended to January 23 - please join the Systems Biology: Global Regulation of Gene Expression meeting in beautiful @CSHL (March 11-14). Register and submit your abstract here: https://t.co/4Ei0Efqzee. Please Repost!

[Alexander Stark @AlexanderStark8]

Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: https://t.co/GkRSD4cB1a . Amazing collaboration by @TedChen1999CN, @Loubiere20 (@IMPvienna, @viennabiocenter), ... (1/2)

[Alexander Stark @AlexanderStark8]

Now on bioRxiv: Activator-promoter compatibility in mammals - Hcfc1 is a key and intrinsically CGI-promoter-specific co-activator that cannot activate non-CGI promoters. Lead by @FilipNemcko & Kevin Sabath in collab. with @plaschka_lab (@IMPvienna) https://t.co/8ILtf7dHPz (1/2)

[Alexander Stark @AlexanderStark8]

Join @fiddle, @MoffittLab, @sara_mostafav, me and all speakers for the 2026 CSHL meeting Systems Biology: Global Regulation of Gene Expression, March 11-14. Abstract deadline January 9! More infos and registration at https://t.co/4Ei0Efqzee

[Filip Nemcko @FilipNemcko]

Read the full story in our preprint! 👇
https://t.co/IaGoM6DkWR
Excited to share this work with my co-first author Kevin Sabath - a fantastic collaboration between the @AlexanderStark8 and @plaschka_lab labs! 🤝🧪