Grace Bower

PhD Candidate in the Kvon Lab @UCIBioSci. 👩🏻‍🔬🧬

[Ubadah Sabbagh @neubadah]

Was not prepared for the graphical abstract

[Evgeny Kvon @evgenykvon]

Our preprint describing the Range Extender element, which is required and sufficient for long-range enhancer activation at the Shh locus, is out in @Nature. https://t.co/qFrjw55BtX

[Grace Bower @gracecbower]

@evgenykvon @Nature Super excited to announce that my first-ever first-author paper is now officially published! 👩🏻‍🔬🎉🧬

[Ethan Hollingsworth @ewholling]

How do non-coding variants in enhancers cause human disease?

Here, in my main PhD work with @evgenykvon, we uncover a surprising mechanism, with generalizable implications for human genomics. https://t.co/UHMAjxs6Qj n/

[Ethan Hollingsworth @ewholling]

The first story of my PhD out now in final published form, including new untested variants (see below)!

[Lorena Hofbauer @LorenaHofbauer]

Beyond happy to share the most exciting findings of my PhD research in the @stark_lab. 🤩

https://t.co/YUSJJ6ses0

Our genome-wide silencer screen revealed that silencers are different from your typical regulatory DNA element.
Find out more below 👇 (1/9)

[Grace Bower @gracecbower]

It was exciting to dig into all the new discoveries in long range gene regulation while writing this!

[Evgeny Kvon @evgenykvon]

In this review, @gracecbower & I discuss recent evidence showing that, unlike canonical enhancers, long-range enhancers located hundreds of kb from their target genes rely on additional mechanisms to ensure robust gene activation during mammal development https://t.co/mRwr1qxKF9

[Michael Kosicki @michaelkosicki]

Updated VISTA Enhancer Browser, 7 years in the making, out in @NAR_Open! >4,500 transgenic in vivo enhancer experiments for all your developmental biology, human variation and #evodevo needs. https://t.co/fE861VE3r7 #enhancers #embryos https://t.co/QxQDzGzBlf

[Juliane Glaser @GJuliane_]

🚨Preprint alert🚨 Excited to share the #preprint version of our work @MundlosLab ! Curious about how a transposable element (TE) insertion can cause developmental phenotypes? 🧬🦠🐁
Check the 🧵 below and the full version on BiorXiv:
https://t.co/C8Yijflrnf

[Katie Galloway @GallowayLabMIT]

in case you're wondering how stable the 3D genome is

[Michael Kosicki @michaelkosicki]

Beta-version of the new VISTA Enhancer Browser, 7 years in the making, with support for developmental stages, different species and variant comparison is finally online. Feedback is welcome! https://t.co/2y5HDCYaKD #enhancers #embryos #evodevo

[Grace Bower @gracecbower]

Beyond proud of the work that went into our latest story! A big shoutout to @evgenykvon for the incredible guidance.

[Evgeny Kvon @evgenykvon]

How do enhancers work over distances that sometimes exceed megabases? Excited to share our work led by @gracecbower where we uncover a unique sequence signature globally associated with long-range enhancer-promoter interactions in developing limb buds: https://t.co/n0p7BdxSdq 1/

[Evgeny Kvon @evgenykvon]

Our preprint characterizing mouse developmental Enhancer—Promoter interactions by @Czx17943830 is out today @NatureGenet https://t.co/hFOtPCl4zV

See also a complementary study on fly Enhancer—Promoter interactions from @Eileen_Furlong https://t.co/MyU1Hhy5i6

[Evgeny Kvon @evgenykvon]

How to test the functional impact of noncoding variants in vivo? Happy to share our work led by @ewholling where we developed dual-enSERT, a new method that enables rapid, quantitative comparison of human enhancer variant activities in live mice. Check this Tweetorial for details

[Zebrafish Rock! @ZebrafishRock]

I’m overwhelmed by the support from the #devbio and #zebrafish communities. This trip has been really special. I met some of my science heroes (@CagneyElayna, @SolnicaKrezelL, @clawedfeet & @chrmosimann) and talked to a lot of amazing people. Tanks everyone ☺️ #2023SDB

[Evgeny Kvon @evgenykvon]

Lots of new insights into Enhancer Biology! Special thanks to @aburger2009 for suggesting this awesome topic for an SDB satellite symposium and to all #2023SDB crew (@Lab_VPrince, Marsha, Laura and Ida) for helping with the logistics.

[Society for Developmental Biology @SocDevBio]

The #2023SDB Meeting will also kick off with the Satellite Symposium ‘Outside of Exomes: Enhancers in Development and Congenital Disease’ organized by @aburger2009 @evgenykvon https://t.co/hQmYINxJGj #2023SDBenh

[Anders Sejr Hansen @Anders_S_Hansen]

(1/n) Excited to share preprint by @ViraatGoel @mileshuseyin

We develop Region-Capture Micro-C (RCMC)

By focusing on specific regions, we generate the deepest 3D genome maps thus far

We see coalescence of enhancer and promoters into “microcompartments”

https://t.co/1Fsd6ixnK9

[Elinor Karlsson (elinork.bsky.social) @eenork]

Humans can be... well... a little self-absorbed... our DNA is the MOST SEQUENCED DNA EVER!

SO. MUCH. DATA.

But are we sooooo special?!? #Zoonomia 1/n