StarkLab

[Vienna BioCenter Scientific Training @TrainingVbc]

Congratulations to @FilipNemcko PhD (@stark_lab, IMP), who recently defended his thesis: 'Systematic identification and functional characterization of transcriptional regulators' - Well done Filip! 🥂🍾 @univienna @IMPvienna @IMBA_Vienna @gmivienna @MaxPerutzLabs

[Bernardo Almeida @deAlmeida_BP]

Nature biotechnology highlighting ours @stark_lab and @steinaerts @ibrahimihsan recent work on designing cell type-specific enhancers 🎉

[Nature Biotechnology @NatureBiotech]

Research Highlight: Designer enhancers for cell-type-specific gene regulation https://t.co/f4NiiVj70o

[StarkLab @stark_lab]

Cracking the 2nd code of life has been a major goal of @AlexanderStark8 and the @stark_lab since their start at the @IMPvienna @ViennaBioCenter in 2008. Big thanks to all members and collaborators, especially @deAlmeida_BP & @Eileen_Furlong who made this possible! (fin)

[StarkLab @stark_lab]

We are very excited to present a major breakthrough achievement – the de novo design of synthetic enhancers for selected tissues in fruit fly embryos in vivo using deep- and transfer learning, @deAlmeida_BPet al published today in @Nature https://t.co/TIlPrBKYaK. Thread 👇(1/N)

[StarkLab @stark_lab]

See also the related and complementary work by @ibrahimihsan @steinaerts (@VIBlifesciences) in fly brains https://t.co/pvynbGsfw2 – together, these publications are the first to read & write enhancer DNA in vivo. (9/N)

[bioRxiv @biorxivpreprint]

Developmental and housekeeping transcriptional programs display distinct modes of enhancer-enhancer cooperativity in Drosophila https://t.co/EbXm43eakn #bioRxiv

[Jelle Jacobs @jacobsjelle1]

Excited to share the final version of my Postdoc work in the @stark_lab on mapping and unravelling the regulatory specificities between transcriptional corepressors (CoRs) and active enhancers. (1/5)
https://t.co/5lYaZoLz2j

[The EMBO Journal @embojournal]

Transcription pre-initiation complex formation & composition is not as uniform as we thought:
@stark_lab @IMPvienna finds distinct PICs acting at housekeeping vs. developmentally-regulated promoters in Drosophila cells
#RefereedPreprint via @ReviewCommons
https://t.co/pXPNHhdghr

[StarkLab @stark_lab]

@LeoSerebreni's PhD work is finally out in EMBO Journal! Leo implemented DNA-affinity purification & mass spec, AID-mediated protein depletion, PRO-seq and more to determine how different promoter types initiate transcription. Congrats to all authors! https://t.co/whgm1ipeik

[IMP @IMPvienna]

🚨 Research paper alert!
Functionally distinct #promoter classes initiate transcription via different mechanisms, according to @LeoSerebreni from the @stark_lab & co-authors. Read more in our interview with him. 👇🏽 1/3
https://t.co/IznOEE608p

[IMP @IMPvienna]

Research paper alert! The @stark_lab shows in @genomeresearch that the activity of #enhancers is encoded through a combination of their motifs’ identity & context. 👇🏽 (1/2)

News article: https://t.co/UVEygko4Qc
Paper: https://t.co/6YqyUCd7wr

[Vienna BioCenter Scientific Training @TrainingVbc]

Monika Heinzl from @jkulinz joined the lab of Alex Stark @stark_lab at @IMPvienna to understand and predict the DNA-sequence encoding of enhancer activity.