@gabrielnavarret@LatinXChem About the coupling in fact it’s very robust and easy to perform. When using a simple SNAr instead I had to perform an arduous purification process to get compounds as pure white solids
@gabrielnavarret@LatinXChem Thanks a lot! Actually the inhibitor with a cyclopentyl moiety was one of the first I synthesized, but through a different route, this one is more practical. But I’m already providing its synthesis by the route highlighted in the poster.
@MarcioPaixao8@LatinXChem FYI I also synthesized with methyl and ethyl groups taking the “secret path” and with a cyclopentyl substituent through a previous route which is not used anymore. 5/5
@MarcioPaixao8@LatinXChem These amines will give us a rational guide to the development of our inhibitor since it comprises different ring sizes, linear and branched chains and also benzylic substituents. 4/5
Hi #LatinXChem👩🏽🔬🇧🇷 🇵🇪, I am glad to present to you our work "Biocatalysis and in silico study applied to asymmetric amine synthesis by transaminases". I am looking forward to your comments :)
@LatinXChem#LXChemBio#BIO068#LatinXChem2021 https://t.co/v9L5En58hF
Hello @LatinXChem, thank u for the opportunity of sharing our work recently published in #JACS.
Here, we applied supramolecular chem concepts in dendritic assemblies to enable the formation of advanced dendrimer-based nanotheranostic devices.
I can't wait to answer the questions!
Hi @LatinXChem, this is my work entitled “Paclitaxel and piplartine co-loaded acetalated dextran nanoparticles for synergistic effect in human breast cancer cells”, #LatinXChem#LXChemNano#Nano109