Magnetic Isolation and Concentration (MagIC)-cryo-EM is a new method to enable direct structural analysis of targets captured on nanomagnetic beads, which requires only 0.0005 mg/mL of targets in 100 µL crude solution to make 10 cryo-EM grids. I will explain the magic behind it!
Image shows characterization of cytosolic Spc105 oligomers. McGory et al. @MarescaLab@UMassAmherst uncover a linkage between the disordered kinetochore protein Spc105 and the dynein-targeting RZZ complex. https://t.co/xMySesTTZB
#Mitosis#CellDivision#Cytoskeleton
Very happy and proud to share the work PhD student Joana Lima @i3S_UPorto “A nuclear signal in prophase determines centrosome positioning and ensures efficient mitotic spindle assembly”, now online. https://t.co/QVu7DgvTdh
Check out our new preprint: An intrinsically disordered kinetochore protein coordinates mechanical regulation of chromosome segregation by dynein https://t.co/P7Gaeda60P
Congrats to #UMass#Biology Assoc. Prof. & Dir. of the Molecular & Cellular Biology Program Tom Maresca @MarescaLab for being awarded a Fulbright Scholar Award! https://t.co/CIGzE3wDnp
Spindle assembly in Xenopus egg extracts! Videos were taken while working late into the night at @MBLScience with Aaron Groen and @GatlinLab. The montage is from our (@viktzv) recent retrospective in @MBoCjournal on a seminal paper by @rebeccaheald. https://t.co/JgFGkuuQMF