Marie

47 & living w #fibromyalgia #dysautonomia #ra #hEDS Engineer in past life. Married w/ 2 #POTS kids, 1 of which has #hEDS. Doing my best. (she/her)

[Marie @Marie_in_KS]

Dreams coming true... feeling well enough to see @NoahKahan and I have a blanket to lay down if I need it.

[Noah Kahan @NoahKahan]

kahanvicts baby https://t.co/hb6L3St5Rt

[Samuel Hume @DrSamuelBHume]

Women are 4-times more likely to have autoimmune diseases than men. Why is this?

From Dou et al. in Cell, today

In females, the second X chromosome is silenced by a long non-coding RNA, called Xist (pronounced 'exist') - males don't express Xist

Xist, together with almost 100 unique proteins, wraps itself around the second X chromosome, silencing it. It's thought that Xist-protein complexes are highly immunogenic, and may represent targets for autoantibodies

Dou et al. devised a system to induce expression of Xist in male mice. They found that Xist expression led to the production of autoantibodies, similar to levels found in female mice (RIBO P0/P2 are lupus autoantibodies, CENPA/B are scleroderma autoantibodies):
In a mouse model, these autoantibodies in Xist-expressing males were sufficient to cause significant lupus pathology (including in the kidney and the lung):
In humans, autoantibodies against the Xist ribonucleoprotein complex were enriched in female patients with lupus, scleroderma, and dermatomyositis

Therefore, Xist may solve the puzzle of female-biased autoimmunity

https://t.co/95sqEMGqJ8

[Marie @Marie_in_KS]

I've been quiet... survival mode again. Trying to get to the pool and I have a new physical therapist working on my hip on top of trying to survive the holidays. #hEDS #MECFS #RA #Fibromyalgia #Dysautonomia

[Marie @Marie_in_KS]

@NoahKahan Nailed it!

[Marie @Marie_in_KS]

My husband took me to the bird store for new feed today. Best guy ever. #25Years

[Marie @Marie_in_KS]

I have finally found a mattress that doesn't aggravate hips & leg nerves while keeping my arms & hands from going numb (side sleeper). It's a good day.
#hEDS #RA #Fibromyalgia

[Marie @Marie_in_KS]

Apparently bird baths are not just for birds this morning.

[Marie @Marie_in_KS]

If you are near KC, check out this documentary on #kcpt. #LGBTQ_ALLY

[Marie @Marie_in_KS]

I've been waiting on an appt w a physical therapist that specializes in hyper mobility. Excited that it's finally only a couple weeks away. Pelvis is still crooked but exercising in the water helps. #hEDS #FingersCrossed

[Marie @Marie_in_KS]

Beautiful juvenile red tailed hawk on our fence looking for chipmunks.

[Noah Kahan @NoahKahan]

wrote an essay for world mental health day @TIME https://t.co/cuFW4njpKG

[Marie @Marie_in_KS]

Some beautiful butterflies lately.

[Marie @Marie_in_KS]

Been quiet lately. All my energy is now going to getting my youngest through his last year in high school & trying to maintain mobility. Hope everyone is hanging in there. Hugs. #MyLife #RA #Fibromyalgia #hEDS #MECFS #dysautonomia

[Marie @Marie_in_KS]

Too much pain in my hip to go walking so I've switched to the pool. My body would be so much better if I lived in water. #Fibromyalgia #ra #dysautonomia #MECFS #hEDS

[Marie @Marie_in_KS]

Cherokee purple tomato. Super mild, low acid, but very interesting shapes this year

[Marie @Marie_in_KS]

What is it? (Hint...Not a body part)

[Marie @Marie_in_KS]

If you get Amazon Prime & you want a good laugh, check out #juryduty. It's been a crappy pain week & I laughed so much it was great.

[Marie @Marie_in_KS]

Another high pain day/night. Am so tired.

[Marie @Marie_in_KS]

@MizzzouSleep More info would be helpful before we share personal data. Link for more study details?