Mark C

#RNAi #Biotech

[Mark C @MarkC_LVB]

@carlquintanilla @barronsonline Ozempic is done, had their run through not surprising Barrons & $GS pumping. $LLY newcomer Trizepatide significantly more effective w/similar side effects and much cheaper w/ Lillydirect. Also $VKTX looming to take them both out in a few years.

https://t.co/TR4rd3Iurd

[Mark C @MarkC_LVB]

Chief Academic Officer for Cardiology at Cleveland clinic also agrees that ASOs inferior to siRNA, at $ARWR discussion in June. Called RNAi and “No Brainer “ over ASOs

https://t.co/qL8eogRGWU

[John Maraganore 🇺🇸🇬🇷🇺🇦 @JMaraganore]

I admittedly have a “dog in the race” here, but I couldn’t agree MORE with @BioCentury and @StephenPHansen!

The facts, are the facts, after all!

[Mark C @MarkC_LVB]

Agree, while both $IONS drugs for LPa & sHTG are ahead of their respective RNAi counter parts from $ARWR $AMGN , they are significantly inferior. The ASOs will be approved first, but within about a year the RNAi drugs will take their market share due to superior efficacy, quarterly dosing, & few side effects.

[Vivek Sen @Vivek4real_]

PALANTIR CTO:

“FOR $10 BILLION, ELON MUSK PUT 300 ROCKETS IN ORBIT.”

“FOR $11 BILLION, THE STATE OF CALIFORNIA HAS BUILT 1,600 FEET OF ELEVATED RAIL...

WITH NO RAIL.”

[Mark C @MarkC_LVB]

@PikaCapital frankly $ARWR never should have been down in the $10 range in the last five years. It just shows how ugly things can get based upon sector sentiment and not reality. The same is true to the upside as we’ve seen with some over inflated stocks. Still undervalued though IMO

[Mark C @MarkC_LVB]

@JeromeAdamsMD This is not a controlled scientific comparison as I’m sure you are aware. Republican districts are more rural with fewer healthcare options available nearby. Is easier to survive a heart attack when you live near the hospital vs 30 miles away. Doesn’t translate politically

[Mark C @MarkC_LVB]

@3IDWarrant @TTRAmyloid He’ll need more than luck...

RE: $ARWR plozasiran vs $IONS olezarsen, Dr Nissen @ R&D event today “Well, this is a no-brainer really. You’ve got a drug that the ASO class has more AEs and shorter duration of action” also not as effective, who wants the ASO?

[Spencer Pratt @spencerpratt]

They're not freezing your rent, they're freezing your housing providers' income, while their expenses keep increasing.

The point isn't to make your housing affordable, it's to make providing housing financially inviable, so government(s) can seize the unmanageable properties.

Our lack of financial literacy is going to destroy us.
https://t.co/Eix9fVp1BK

[Mark C @MarkC_LVB]

@RWMaloneMD This is not an example of the pharmaceutical industry being broken. This is an example of the insurance industry being broken.

[Clown World ™ 🤡 @ClownWorld]

Elon Musk’s wealth is in shares, not a checking account. Force a tax like that and he has to sell stock, the company loses value, thousands of employees lose their jobs, and the government still doesn’t get anywhere close to what you’re promising. This take is what happens when you’ve never run a business in your life.

[Mark C @MarkC_LVB]

@Biohazard3737 Best place in the world we’ve ever visited.

[Mark C @MarkC_LVB]

@pjsandiegosdca @DrNeilStone He made something that became very valuable, why is that so hard to understand? And who is the arbiter of what is too much for someone else to have?

His wealth is not created by taking from others, on the contrary, he has added to the economy in ways previously not attainable.

[Mark C @MarkC_LVB]

One of the biggest things the left can do is to understand basic economics & math.

Wealth is not created by taking from others, but expanding the marketplace. If wealth was static, everything we have financially would be the same as 200 years ago. However today’s poor have more opportunity than any king from that time.

[Geiger Capital @Geiger_Capital]

@RoKhanna The US budget is $7.4 Trillion you moron.
Tax revenue is at record highs.

Forget about 5%… if you socialists confiscated 100% of his net worth, it would last ~45 days.
And then what?

We don’t have a revenue problem.
It’s you clowns spending it.

[Dave Portnoy @stoolpresidente]

I find the 2 most insufferable group of people on the planet are lifetime educators and lifetime politicians. Both live in a fantasy world that lacks common sense and would not survive a day in the real world

[Mark C @MarkC_LVB]

@Delta how is someone supposed to make this connection in DTW at the end of the night on a scheduled 30 minute layover?

[Mark C @MarkC_LVB]

@elonmusk @zerohedge X premium subscribers should be given priority access to the IPO🤔😁

[Mark C @MarkC_LVB]

@LuckyTraveling Obviously, you’re not familiar with the Frettita portfolio of high end steakhouses. They operate Matros, Del Friscos, Strip House, and Morton’s to name a few. Yes they have a lower end portfolio as well, but to focus on the low end w/o mentioning these brands is disingenuous.

[Mark C @MarkC_LVB]

@YBT1903 @British_Airways The only thing premium anymore in regards to British Airways Club World, is the price

[Mark C @MarkC_LVB]

@British_Airways the Club Europe flight attendants on BA 472 from LHR to Barcelona are great, especially Dominique she’s been fantastic. The past days travel with BA at Heathrow has been a major headache, but these folks have made a bad experience better.

[Mark C @MarkC_LVB]

@genecodex @DENAirport Connotation of a pedestrian means he was just minding his own business walking in a normal place, not on a runway. Implications are important, a reader might think this the fault of the airline or crew.