Max Unfried

Man of Science 🧬 AI & Gerophysics to understand Aging. 🇸🇬 Rethinking the Fundamentals of Aging & Rejuvenation Biology @TTIScience 🇺🇸

[Max Unfried @MaxUnfried]

Longevity Hack: Don’t hang out with obese people.

[Max Unfried @MaxUnfried]

@Elena_Vitalist Just for workouts. Sparring is probably the better word.

[Max Unfried @MaxUnfried]

The only time I’m not thinking about the biology of aging is while fighting or during sex.

[Max Unfried @MaxUnfried]

Professorship is still training, and even more costly.

Most professors are in a state where they are a.) bad at managing their lab as they haven’t been trained for it and b.) past their prime when it comes to doing actual science, as they don’t have the time to dedicate to it.

[Kevin A. Bryan @Afinetheorem]

Ok, last thing, and I know it's unpopular, but on "grad students make this place run" and are "workers": when you become a professor, you will learn this is completely untrue. Love our students, but they are *students* and incredibly costly ones. 1/3

[Max Unfried @MaxUnfried]

@Aging_Scientist I can tell you from my editorial activities so much AI slop is being created and submitted and it increased massively in the past 18 month, most stay unchecked on preprint servers.

[Max Unfried @MaxUnfried]

Recursive self-degradation.

A lot of AI slop science is increasing the noise-to-signal ratio and polluting the LLM training data.

[Crémieux @cremieuxrecueil]

My findings replicated again!

arXiv preprints are increasingly AI-written. The rate is almost 40% of new submissions!

[Max Unfried @MaxUnfried]

Biohackers are the only group that’s even less successful than academics in proofing an „intervention“ is beneficial to health.

[Jake Wintermute 🧬/acc @SynBio1]

The life of a mercenary biohacker isn’t easy

Sure, traveling to elite labs to work on biological millennium problems might seem very sexy and mysterious and cool - and it is

But sometimes I think I might love the Bio-AI game too much. It haunts me in a very sexy and mysterious way

[Max Unfried @MaxUnfried]

@namehra That could work.

[Max Unfried @MaxUnfried]

Should I change my name to Max Lifespan?

[Steve Martin @RighttoTryGuy]

If they discovered the cure for all of these diseases TOMORROW they still wouldn't be treating any patients outside of clinical trials for another decade.

If you work at @AnthropicAI and you want this promise to come true, you need to have a strategy to come to Montana. Don't let the "standard playbook" determine your drug development strategy during the singularity, approach your go to patient strategy with the same sort of innovative mindset you approach everything else with. Reach out to @MontanaETRB or DM me!

[Max Unfried @MaxUnfried]

Very cool to see some new approaches in classic machine learning.

Another area to improve on would be phylogenetic methods, as for some fields we won’t just get more data e.g the number of vertebrates is around 65,000 and won’t change much.

[Swann Bessa @swann_bessa]

Introducing e-means, an algorithm beating k-means in 10x fewer epochs.

With order of magnitude wall-clock speedups, e-means is released in FAISS and needs no hyperparameter tuning beyond k. It is robust to various scales and datasets. Still skeptical ? Just try e-means [1/10]🧵

[Max Unfried @MaxUnfried]

This is super cool that archeology as a hobby is now doable.

[Pietro Miotti @PietroMiotti]

My AI agents found an unmapped Maya site in Mexico, using LiDAR data from a NASA dataset.

72 hours from a random thought on vacation to a reply from Mexico's national archaeology institute.

What a time to be alive…

[Pietro Miotti @PietroMiotti]

My AI agents found an unmapped Maya site in Mexico, using LiDAR data from a NASA dataset.

72 hours from a random thought on vacation to a reply from Mexico's national archaeology institute.

What a time to be alive…

[Max Unfried @MaxUnfried]

@nntaleb Probably also makes poop nice 💩

[Jun Axup Penman @junaxup]

We're on a hiring spree! Job #2 just dropped. More to come later this week. 👀

[Max Unfried @MaxUnfried]

@HenningLanger Thank you for calling it out!

[Max Unfried @MaxUnfried]

Beautiful

[Yesh @YeshodharaB]

"Scientists are people of very dissimilar temperaments doing different things in very different ways. Among scientists are collectors, classifiers and compulsive tidiers-up; many are detectives by temperament and many are explorers; some are artists and others artisans. There are poet-scientists and philosopher-scientists and even a few mystics. What sort of mind or temperament can all these people be supposed to have in common? Obligative scientists must be very rare, and most people who are in fact scientists could easily have been something else instead."

- Medawar

[Max Unfried @MaxUnfried]

@cremieuxrecueil Seems like a worthwhile visit. I’m in Tokyo for a month so gonna check it out.

[Max Unfried @MaxUnfried]

It’s is a very thorough piece that raises many valid points of criticism.

Only thing he should also criticize in it, is the reliance on mice as researcher models, or at least be honest that they are great for academic publishing, but most mouse studies are irrelevant for aging science, unless the goal is to understand mouse aging.

[João Pedro de Magalhães @jpsenescence]

A scorched-earth approach to aging research by Rich Miller 🔥

Pretty much everything gets criticised, from the hallmarks of aging to cell senescence, epigenetic clocks, and cellular rejuvenation.

But Rich makes some very good points. I particularly like the Rolex analogy regarding aging clocks.

If you’re working in aging science, please read it and thank me later! It's an entertaining and much-needed critical perspective.

For the record, I was a reviewer of this paper, and suggested a little more nuance and balance. My suggestions didn't make it to the final version, though. Why be balanced when you can just burn everything in your path! 🔥

https://t.co/I7BUNoK2W2

[João Pedro de Magalhães @jpsenescence]

A scorched-earth approach to aging research by Rich Miller 🔥

Pretty much everything gets criticised, from the hallmarks of aging to cell senescence, epigenetic clocks, and cellular rejuvenation.

But Rich makes some very good points. I particularly like the Rolex analogy regarding aging clocks.

If you’re working in aging science, please read it and thank me later! It's an entertaining and much-needed critical perspective.

For the record, I was a reviewer of this paper, and suggested a little more nuance and balance. My suggestions didn't make it to the final version, though. Why be balanced when you can just burn everything in your path! 🔥

https://t.co/I7BUNoK2W2