Maximilian Stötzel

PhD in Molecular Genetics, Post-Doctoral Scientist at Novo Nordisk Foundation Center for Stem Cell Medicine – reNEW. Brickman lab, Organoids and Embryos.

[Maximilian Stötzel @Maxistoe]

This interaction may help to maintain master developmental regulators in a "poised" state, suggesting a role for mTOR in linking environmental cues to the timing of gene activation.
Read the preprint here:
https://t.co/LGrM2pE4AM

[Maximilian Stötzel @Maxistoe]

mTOR and Chromatin Regulation: An Environmental-Epigenetic Axis
In our new preprint, we demonstrate that mTOR, the central regulator of cell growth and metabolism, functions as a chromatin regulator in mouse ESCs.

[Maximilian Stötzel @Maxistoe]

We find that nuclear mTOR selectively binds to developmental gene promoters in synergy with PRC1-deposited H2AK119ub1.
At these sites, mTOR associates with the RNA Polymerase II machinery and coincides with high levels of RNA Pol II pausing.

[Maximilian Stötzel @Maxistoe]

@RCarhartHarris Very enjoyable read! Thanks for sharing.

[Josh Brickman @josh_brickman]

How does metabolism act through generic chromatin modifiers promote specific cellular states? Simultaneous modification of transcription factors and chromatin, enhancing epigenetic signal to noise ratios.
https://t.co/SUx8ZninUo

[Jan Żylicz @JZylicz]

Can metabolism regulate more than bioenergetics during human development? Our new study says YES! We show that metabolism influences cell fate choice in human naïve pluripotent stem cells, histone acetylation, and trophectoderm maturation. https://t.co/5Ms6tNyT5l @NatureCellBio

[Jamie Hackett @hackettlab]

📢 Preprint! Does the environment of a father before conception influence offspring?

Even more, how do paternal genetics & age interact with exposures to affect F1 outcome?

We tested this systematically, with intriguing findings & some cautionary tales

https://t.co/THGgCcMQNL

[Maximilian Stötzel @Maxistoe]

What a cool surprise on a Friday afternoon - our story on the cover of @NatureSMB.
@bulutkarslioglu @MPI_MolGen

[Maximilian Stötzel @Maxistoe]

@MatthewKraushar @Tagesspiegel @MPI_MolGen Way to go Matt!

[MPI for Molecular Genetics @MPI_MolGen]

🎓Join the @bulutkarslioglu lab & our #IMPRS-BAC #gradschool to solve the key questions at the heart of cellular identity! As a PhD student, you will decipher the crosstalk between gene regulatory layers in #stemcells. #molecularbiology #development
👉 https://t.co/CScfGZZm43

[Philine @PGuckelberger]

I am so excited to share this part of my PhD where we tackle the question: What impact do 3D contacts have on how enhancers regulate their target genes? https://t.co/wtyAWg4c4j

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[ludovic vallier @VallierLab]

A nice video from Fabian Bachinger @VallierLab describing his research on large scale production of hepatocytes for cell based therapy. Thank you @wellcome_leap for supporting us the past 3 years #WellcomeLeap
https://t.co/Lybr1gQIXu

[Maximilian Stötzel @Maxistoe]

Honored to receive the @ISSCR Merit Award! It's been a great meeting with inspiring conversations so far!

[ISSCR @ISSCR]

Congratulations to the #ISSCR2024 Travel & Merit Award Winners! Thank you to all of our supporters.

[Julian Naderi @Naderij_]

Human TFs face a molecular trade-off between activity and specificity encoded as submaximal dispersion of aromatic residues in their disordered regions. A collaborative effort of @dhnisz, @VingronLab and Graf Lab published today in @NatureCellBio https://t.co/OkvRuF6nhT

[MPI for Molecular Genetics @MPI_MolGen]

The @dhnisz lab with the @VingronLab found chemical features in transcription factors (TFs) that encode submaximal transcriptional activity. The findings in @NatureCellBio hint ways to create optimized TFs that could be used for regenerative therapies. --> https://t.co/W32EkGftOE

[Adriano Bolondi, PhD @adrianobolondi]

Humbled & excited that our paper on molecular recording of cellular decision in Trunk-Like Structures (TLS) got featured on the cover of @Dev_Cell! w/ B. Law, M. Chan @Princeton, Z. Smith @Yale, A. Meissner @MPI_MolGen & @jvveenvliet!

Link to the paper:
https://t.co/dqLLoF4r2n

[MPI for Molecular Genetics @MPI_MolGen]

1/2 The presence of extraembryonic cells in the developing gut has long puzzled scientists. @BatkiJulia (l) and @hetzel_s (r) (#Meissner lab) now gained new insight into the fate and molecular characteristics of these cells. @NatureCellBio Read more: https://t.co/YOHN9v4VxK

[Maximilian Stötzel @Maxistoe]

@_YiBei Congrats!

[MPI for Molecular Genetics @MPI_MolGen]

Great panel discussion on the future of Berlin science with Georg Duda @berlinnovation, @maxplanckpress Vice President @AsifaAkhtar1, Christian Rommel @BayerPharma, and MPIMG Director Alexander Meissner at our #MPIMG60years celebration!

[Maximilian Stötzel @Maxistoe]

@_taktas_ Thanks @_taktas_. I feel very honored!