Sara Hetzel

Postdoc @ Hasso Plattner Institute for Digital Engineering. She/her

[MPI for Molecular Genetics @MPI_MolGen]

1/2 The presence of extraembryonic cells in the developing gut has long puzzled scientists. @BatkiJulia (l) and @hetzel_s (r) (#Meissner lab) now gained new insight into the fate and molecular characteristics of these cells. @NatureCellBio Read more: https://t.co/YOHN9v4VxK

[MPI for Molecular Genetics @MPI_MolGen]

🧬 The placenta's DNA is strange: its methylation patterns are scattered throughout. This is the result of two enzymes that normally work in their respective pens but compete in the placenta, as @hetzel_s @RahaWeigert show in @NatureCellBio. #Meissner Lab https://t.co/r2XtugBGmo

[Nature Cell Biology @NatureCellBio]

☕️NEW ONLINE: Meissner, Smith & co show that an antagonistic relationship between DNA methyltransferase and Polycomb activity is globally responsible for the maintenance of intermediate methylation levels observed in trophoblast stem cells.
https://t.co/YEBSx93x2W

[Sara Hetzel @hetzel_s]

Excited to share our work discovering a dynamic antagonism between #DNMT3B and #Polycomb that maintains the placental epigenome. Check out @RahaWeigert thread for more details 👇👇 @MPI_MolGen

[Raha Weigert @RahaWeigert]

Ever wondered how the peculiar placental epigenome is regulated? We discovered a dynamic DNMT3B/Polycomb-antagonism that maintains it! Beyond thrilled to share my PhD work together with @hetzel_s published @NatureCellBiology. @MPI_MolGen #MeissnerLab (1/9) https://t.co/x5vjLyQUHe

[Alexandro Landshammer, PhD @Langsammer03]

🚨!!!Preprint Alert!!!🚨 I am super-delighted to share our work co-led with @adrianobolondi describing the discovery and characterization of a novel lncRNA, LNCSOX17, a key regulator of human definitive endoderm. #Meissner Lab @MPI_MolGen. A🧵1/11 https://t.co/RbO2tRJLID

[Abhishek Sampath Kumar @AbhiSampKumar]

Very excited to share the first piece of work from my PhD with @VahidAsimi
@henri_niskanen @chri7stina @hetzel_s @dhnisz out today in @NatureGenet https://t.co/AGAlFgzDYQ @MPI_MolGen

[Adriano Bolondi, PhD @adrianobolondi]

Our review on new opportunities offered by single-cell technologies for investigating epigenetic regulation during mouse development is out today in @sciencedirect! A team effort with @helenekretzmer and Alex Meissner @MPI_MolGen. A short thread🧵

https://t.co/ohTeDAfMmY

[Sara Hetzel @hetzel_s]

This work would not have been possible without the work and dedication of my wonderful colleagues and collaboration partners @AL_Mattei, @helenekretzmer, @CMullighan, Alex Meissner and many others!

[Sara Hetzel @hetzel_s]

Excited to share my PhD work now out @NatureCancer! We explored the methylome of acute lymphoblastic #leukemia and found that unlike the classic global hypomethylation found in tumors, ALL exhibits strikingly high genome-wide #DNAmethylation levels. https://t.co/WZDfFrOG3e

[Sara Hetzel @hetzel_s]

We also show that CpG island hypermethylation levels in T-ALL patients span a wide range and highlight a role of #TET2 and #DNMT3B in shaping this landscape. #CancerEpigenetics

[Sara Hetzel @hetzel_s]

Outstanding work by my brilliant colleagues who spent many months collecting and summarizing the key pieces to take us on a journey through the history of DNA methylation research. A must-read for anyone in the field and beyond.

[Alexandra Mattei @AL_Mattei]

What does DNA methylation do again? Our answer in 32 short pages. Excited to finally get to share a true labor of love Nina Bailly and I worked on together throughout the pandemic, a swan song to my PhD and time in Germany. https://t.co/2PrbMim23e

[Sara Hetzel @hetzel_s]

@S_Grosswendt @ERC_Research @berlinnovation @ChariteBerlin @BIMSB_MDC @MDC_Berlin Congratulations!

[Sara Hetzel @hetzel_s]

@anshulkundaje Our lab has looked at the KOs of different epigenetic regulators with scRNAseq wrt transcriptional changes, changes in cell state proportions and developmental delay https://t.co/mdH14eClpK

[SeqAn @SeqAnLib]

🎉 SeqAn 3.1.0 released 🎉
We are happy and proud to announce a new release of the modern #CPP library for sequence analysis. Find out more about it at https://t.co/r6Bak4KlbR or check it out right away https://t.co/pUSovbkaI8. Many thanks to all contributors and supporters.

[Sara Hetzel @hetzel_s]

Thanks to the team @SeqAnLib for providing such an efficient framework for the development of biological sequence analysis tools with #cplusplus. RLM is available via GitHub: https://t.co/mQIEgsLrAS

[Sara Hetzel @hetzel_s]

Happy to present the first work of my PhD: RLM, a tool that enables efficient computation of read-level #DNAmethylation metrics from bisulfite sequencing data with @PayGiesselmann, @KnutReinert, Alex Meissner and @helenekretzmer
https://t.co/uyNFWyhBlB

[MPI for Molecular Genetics @MPI_MolGen]

🚨 #Job Alert! Computational #PhDposition (2/2): investigate the role of #epigenetics during development & regeneration, with cutting-edge HT technologies, incl #scRNAseq data at the #MeissnerLab

Join us & apply for your #PhD in Berlin until July 21!

🔗 https://t.co/esBifS8s8i

[MPI for Molecular Genetics @MPI_MolGen]

🚨 #Job Alert! Computational #PhDposition (1/2): investigate #epigenomics in #cancer and development, using cutting-edge high-throughput technologies at the #MeissnerLab.

Join us & apply for your #PhD in Berlin until July 21!

🔗 https://t.co/WCiosmnTGb

[Adriano Bolondi, PhD @adrianobolondi]

Beautiful methylation pearl by Chuck Haggerty, @helenekretzmer, @chri7stina, @AbhiSampKumar, @AL_Mattei, N Bailly, @RahaWeigert & others on the "secret life" of Dnmt1 at #IAPs (as Chuck would say!). Congrats my friends! #MeissnerLab @MPI_MolGen @NatureSMB
https://t.co/TRlrnKZLrD

[Sara Hetzel @hetzel_s]

Check out the newest publication from our lab! Congratulations @helenekretzmer

[MPI for Molecular Genetics @MPI_MolGen]

🧬 How does the #methylome of chronic lymphocytic leukemia change over time – from precursor stage to after therapy? It’s remarkably stable, @helenekretzmer found out in her new @BCD_AACR paper: https://t.co/KbziyHIf9H #ASH20