Mayo Clinic Kullo Laboratory

Atherosclerosis & Lipid Genomics Laboratory @MayoClinic | Focused on Improving Patient Outcomes | Heritable Cardiovascular Diseases | Led by Dr. Iftikhar Kullo

[Mayo Clinic Kullo Laboratory @MayoClinic_KLab]

Congratulations to our PI and mentor, Dr. Kullo for being invited to serve on the National Advisory Council for Human Genome Research!
@iftikhar_kullo

[Iftikhar J. Kullo @iftikhar_kullo]

Honored to serve on National Advisory Council for Human Genome Research along with distinguished colleagues
@howardychang @OlgaTroyanskaya @kylebrothers @genegj @ssr4n Hal Dietz, Laura Beirut, Lynne Jorde, Len Pennachio, Mark Craven, Lisa Parker, Peter Robinson, @NHGRI_Director

[Iftikhar J. Kullo @iftikhar_kullo]

Disclosure of high genetic risk is often associated with no significant measures to mitigate risk
@Naderian_mr & I comment on a syst review on
behavior outcomes after disclosing CV genetic risk
Genetic risk disclosure and behavioural change: not so fast https://t.co/vtNbTAf8y1

[Annals of Int Med @AnnalsofIM]

Read about how including genetic, social, lifestyle, and psychological factors in clinical risk calculators for #heartdisease could improve their ability to predict coronary heart disease: https://t.co/iZIvs16ShO

[Annals of Int Med @AnnalsofIM]

Trending now at https://t.co/HQyUgwV2bm: Development and Evaluation of a Comprehensive Prediction Model for Incident Coronary Heart Disease Using Genetic, Social, and Lifestyle–Psychological Factors: A Prospective Analysis of the UK Biobank: https://t.co/lLsybgivSq

@MayoClinic

[ASHG @GeneticsSociety]

🗓️TOMORROW! Learn how the NIH's PRIMED Consortium is advancing equitable polygenic risk predictions via its methods and tools w/ speakers @iftikhar_kullo, MD, & Sarah C. Nelson, MPH, PhD. It's not too late to register 👉 https://t.co/jHpkbIIqDX #ASHG

[Michael J. Ackerman MD,PhD @MJAckermanMDPhD]

About to wrap up Session III w/ my friend & co-director ⁦@iftikhar_kullo⁩ sharing exciting advances in the familial hyperlipidemias. Love seeing the desire in our 100+ attendees to become more fluent in the language of #Genetic #Cardiology.

[Mohammadreza (Reza) Naderian @Naderian_mr]

1/3
📊 Excited to share our latest publication in @AnnalsofIM from @MayoClinic_KLab, @iftikhar_kullo, as a step toward a more personalized risk prediction for CHD 🫀

https://t.co/OoR5bSMqva

[Iftikhar J. Kullo @iftikhar_kullo]

⁦@roxanne_coderre⁩ at our 8th CV genomics course presenting a Case of very severe hypercholesterolemia due to compound heterozygosity in LDLR

[Mayo Clinic Genetic Heart Rhythm Clinic @MayoClinicWSRGH]

We are joined by the team of @MJAckermanMDPhD @iftikhar_kullo @T_Kruisselbrink and @nl_pereira for the final panel of the day. These experts and attendees are diving into the latest advancements, challenges revolving around genetic cardiology! @MayoClinicCV @MayoClinic #genetics

[Mayo Clinic Genetic Heart Rhythm Clinic @MayoClinicWSRGH]

@iftikhar_kullo is now sharing insights on the interpretation and utilization of polygenic risk scores in clinical practice, helping attendees learn how these scores are transforming personalized medicine. @MayoClinic @MayoClinicCV #CardioGenetics #HeartHealth #GHRC #genetics

[Iftikhar J. Kullo @iftikhar_kullo]

Looking forward to a great meeting in a great location!

This is our 8th CME course on CV genomics covering general principles, monogenic & polygenic conditions, as well as exciting advances in therapy

Privileged to co-direct with the @MJAckermanMDPhD and @nl_pereira

[Iftikhar J. Kullo @iftikhar_kullo]

Polysocial score (PSS) was higher in non-whites

The greater CHD risk in non-whites may be partly due to higher PSS

The effect of PSS and PRS on CHD risk was independent and additive

At a 7.5% 10-y risk threshold, adding both PSS and PRS led to a 12% reclassification rate

[Iftikhar J. Kullo @iftikhar_kullo]

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A UK Biobank analysis by @Naderian_mr highlights the value of incorporating social & environmental factors as well as #PRS to improve CHD risk prediction

Main findings:
1 SD increase in a polysocial score led to a HR of 1.43 & a 1 SD increase in PRS led to a HR of 1.59

[Eric Topol @EricTopol]

With more layers of data, our ability to predict a person's risk of heart disease is getting better and better
https://t.co/BI0ltvTodY @AnnalsofIM adding in social determinants of health, lifestyle, and other data @iftikhar_kullo @uk_biobank

[Annals of Int Med @AnnalsofIM]

Model shows how data on genetic, social, and lifestyle-psychological factors help better predict individual heart disease risk. https://t.co/qwkHJzJOIW

@Naderian_mr @MayoClinicCV @iftikhar_kullo @MayoClinic

[PRIMED Consortium @PRSmethods]

A new Perspective from @PRSDiversity is out in @AJHGNews! PRIMED is bringing together researchers and data from across the globe to develop new polygenic risk score methods and improve risk prediction across diverse populations and genetic ancestries🧵 1/
https://t.co/Y8FIuRxvs8

[Iftikhar J. Kullo @iftikhar_kullo]

See also this report by Satterfield et al.
describing MR phenome wide analyses of genetically predicted Lp(a) levels

It is unclear, however, whether Lp(a) is equally atherogenic in individuals of African genetic ancestry.

https://t.co/JmwkkDiVoP

#LPA

[Iftikhar J. Kullo @iftikhar_kullo]

SDOH and PRS were independently associated with CHD

Including both PRS and SDOH in CHD risk models could improve their accuracy

Accompanying editorial by Dr. Nilay Shah here

https://t.co/xxUOJdnhg1

[Iftikhar J. Kullo @iftikhar_kullo]

1/2

Associations of Race, SDOH & PRS with CHD risk in the All of Us dataset by Kristjan Norland

https://t.co/XrN1YorQKP

⬆️ odds of CHD in people who self-report as Black are due to a higher SDOH burden

Emphasizing Race as a social not biological construct

[Mayo Clinic Kullo Laboratory @MayoClinic_KLab]

@iftikhar_kullo @AnnalsofIM @JACCJournals @AJHGNews Congratulations to all authors on this important effort!

[Marios Georgakis @MariosGeorgakis]

The PRIMED consortium represents an effort to share genetic data and develop polygenic risk scores that work equally well across ancestries.

Important step towards addressing the historical oversampling of Europeans in GWAS studies.

🔗https://t.co/47uo8OOqRA